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Cntnap1
Gene Detail
Symbol

Name
ID
Cntnap1
contactin associated protein-like 1
MGI:1858201
Synonyms
Caspr, NCP1, Nrxn4, p190, paranodin, shm
Feature Type
protein coding gene
Genetic Map
Chromosome 11
64.33 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:101170523-101190724 bp, + strand
From VEGA annotation of GRCm38

  20202 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2693  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: paranodin
Gene Tree: Cntnap1

Human
homologs
Human Homolog CNTNAP1, contactin associated protein 1
NCBI Gene ID 8506
neXtProt AC  NX_P78357
Human Synonyms  CASPR, CNTNAP, NRXN4, P190
Human Chr (Location)  17q21; chr17:42680395-42699993 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(1) Radiation induced(1) Spontaneous(4) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit reduced body size and nervous system defects, including impaired balance, hypoactivity, and and ataxia.
 
Interactions
Cntnap1 interacts with 247 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process axon cargo transport, cell adhesion, ...
Component axon, cell, ...
Function SH3 domain binding
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (1)    Tissues (1)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000002728 (Evidence)
Ensembl Gene ModelENSMUSG00000017167 (Evidence)
Entrez Gene53321 (Evidence)
UniGene474527
DFCITC1589615, TC1677730
DoTSDT.101358145, DT.87040081
Consensus CDS ProjectCCDS25455.1
International Mouse Knockout Project StatusCntnap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002728 VEGA Gene Model | MGI Sequence Detail 20202 C57BL/6J ±  kb
transcript OTTMUST00000005414 VEGA | MGI Sequence Detail 5440 Not Applicable 
polypeptide OTTMUSP00000002577 VEGA | MGI Sequence Detail 1385 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(56 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000421 Coagulation factor 5/8 C-terminal type domain
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR001791 Laminin G domain
InterPro IPR003585 Neurexin/syndecan/glycophorin C
Protein Ontology PR:000005672 contactin-associated protein 1
References
(Earliest) J:5040 Green EL, Shambling, a neurological mutant of the mouse. J Hered. 1967 Mar-Apr;58(2):65-8
(Latest) J:197981 Susuki K, et al., Three mechanisms assemble central nervous system nodes of Ranvier. Neuron. 2013 May 8;78(3):469-82
All references(74)
Other
accession IDs
MGD-MRK-14405, MGI:2144280, MGI:98298

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory