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Cntnap1
Gene Detail
Symbol

Name
ID
Cntnap1
contactin associated protein-like 1
MGI:1858201
Synonyms
Caspr, NCP1, Nrxn4, p190, paranodin, shm
Feature Type
protein coding gene
Genetic Map
Chromosome 11
64.33 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:101170523-101190724 bp, + strand
From VEGA annotation of GRCm38

  20202 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2693  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CNTNAP1
Protein SuperFamily: paranodin
Gene Tree: Cntnap1

Human
homologs
CNTNAP1, contactin associated protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8506
neXtProt AC: NX_P78357

Human Synonyms: CASPR, CNTNAP, NRXN4, P190

Human Chr (Location): 17q21; chr17:42682614-42699993 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CNTNAP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(1) Radiation induced(1) Spontaneous(4) Targeted(8)
Genomic Mutations involving Cntnap1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice exhibit reduced body size and nervous system defects, including impaired balance, hypoactivity, and and ataxia.
 
Interactions
Cntnap1 interacts with 246 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell adhesion, cytoskeleton organization, ...
Component axon, integral component of membrane, ...
Function SH3 domain binding
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (1)    Tissues (1)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase cntnap1 ; ZFIN cntnap1    NEW 
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000002728 (Evidence)
Ensembl Gene Model ENSMUSG00000017167 (Evidence)
Entrez Gene 53321 (Evidence)
UniGene 474527
DFCI TC1589615, TC1677730
DoTS DT.101358145, DT.87040081
Consensus CDS Project CCDS25455.1
International Mouse Phenotyping Consortium Status Cntnap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002728 VEGA Gene Model | MGI Sequence Detail 20202 C57BL/6J ±  kb
transcript OTTMUST00000005414 VEGA | MGI Sequence Detail 5440 Not Applicable 
polypeptide OTTMUSP00000002577 VEGA | MGI Sequence Detail 1385 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(56 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000421 Coagulation factor 5/8 C-terminal domain
InterPro IPR013320 Concanavalin A-like lectin/glucanase domain
InterPro IPR028872 Contactin-associated protein 1
InterPro IPR000742 EGF-like domain
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR001791 Laminin G domain
InterPro IPR003585 Neurexin/syndecan/glycophorin C
Protein Ontology PR:000005672 contactin-associated protein 1
References
(Earliest) J:5040 Green EL, Shambling, a neurological mutant of the mouse. J Hered. 1967 Mar-Apr;58(2):65-8
(Latest) J:221647 Hirono M, et al., BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells. J Neurosci. 2015 May 6;35(18):7082-94
All references(79)
Other
accession IDs
MGD-MRK-14405, MGI:2144280, MGI:98298

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory