About   Help   FAQ
Cntnap1 Gene Detail
Summary
  • Symbol
    Cntnap1
  • Name
    contactin associated protein-like 1
  • Synonyms
    Caspr, NCP1, Nrxn4, p190, paranodin, shm
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858201
    NCBI Gene: 53321
  • Gene Overview
    MyGene.info: CNTNAP1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101174649-101190723 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 64.33 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    51 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858201
protein coding gene Chr11:101170523-101190724 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019185
protein coding gene Chr11:103998213-104020547 (+)
A/J MGP_AJ_G0019153
protein coding gene Chr11:99632362-99653678 (+)
AKR/J MGP_AKRJ_G0019122
protein coding gene Chr11:102730142-102751819 (+)
BALB/cJ MGP_BALBcJ_G0019127
protein coding gene Chr11:100123568-100143879 (+)
C3H/HeJ MGP_C3HHeJ_G0018936
protein coding gene Chr11:102898413-102920669 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019576
protein coding gene Chr11:107219286-107239474 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017202
protein coding gene Chr11:97051535-97072039 (+)
CAST/EiJ MGP_CASTEiJ_G0018490
protein coding gene Chr11:103890035-103911508 (+)
CBA/J MGP_CBAJ_G0018905
protein coding gene Chr11:111679350-111699525 (+)
DBA/2J MGP_DBA2J_G0019017
protein coding gene Chr11:99163016-99183800 (+)
FVB/NJ MGP_FVBNJ_G0019007
protein coding gene Chr11:98709867-98730124 (+)
LP/J MGP_LPJ_G0019086
protein coding gene Chr11:104545174-104566957 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019038
protein coding gene Chr11:111237064-111267323 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019614
protein coding gene Chr11:103048317-103070681 (+)
PWK/PhJ MGP_PWKPhJ_G0018253
protein coding gene Chr11:100214784-100235595 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018045
protein coding gene Chr11:102793800-102815867 (+)
WSB/EiJ MGP_WSBEiJ_G0018539
protein coding gene Chr11:103049029-103072866 (+)



Homology
more
  • Human Ortholog
    CNTNAP1, contactin associated protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CNTNAP1, contactin associated protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CASPR, CNTNAP, NRXN4, P190
  • Links
    NCBI Gene ID: 8506
    neXtProt AC: NX_P78357
    UniProt: P78357

  • Chr Location
    17q21.2; chr17:42679963-42699993 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 9 alleles in 9 genetic backgrounds
    5 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit reduced body size and nervous system defects, including impaired balance, hypoactivity, and ataxia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53321 NCBI Gene Model | MGI Sequence Detail 16075 C57BL/6J ±  kb
    transcript NM_016782 RefSeq | MGI Sequence Detail 5360 C57BL/6  
    polypeptide O54991 UniProt | EBI | MGI Sequence Detail 1385 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14405, MGI:2144280, MGI:98298
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 13
      Gene Ontology 12
      Phenotypes 46
    • Earliest
      J:5040 Green EL, Shambling, a neurological mutant of the mouse. J Hered. 1967 Mar-Apr;58(2):65-8
    • Latest
      J:241111 Wu ZQ, et al., Caspr Controls the Temporal Specification of Neural Progenitor Cells through Notch Signaling in the Developing Mouse Cerebral Cortex. Cereb Cortex. 2017 Feb 01;27(2):1369-1385

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory