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Folh1 Gene Detail
Summary
  • Symbol
    Folh1
  • Name
    folate hydrolase 1
  • Synonyms
    GCP2, glutamate carboxypeptidase II, mopsm, prostate-specific membrane antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858193
    NCBI Gene: 53320
  • Gene Overview
    MyGene.info: FOLH1
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:86718977-86775943 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 48.51 cM, cytoband D1-D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    785 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858193
protein coding gene Chr7:86718976-86776054 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032485
protein coding gene Chr7:88989853-89055937 (-)
A/J MGP_AJ_G0032459
protein coding gene Chr7:86908107-86965652 (-)
AKR/J MGP_AKRJ_G0032396
protein coding gene Chr7:88974332-89032661 (-)
BALB/cJ MGP_BALBcJ_G0032472
protein coding gene Chr7:86582537-86639791 (-)
C3H/HeJ MGP_C3HHeJ_G0032185
protein coding gene Chr7:89355005-89416611 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032969
protein coding gene Chr7:92566995-92622615 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029965
protein coding gene Chr7:89296520-89344588 (-)
CAST/EiJ MGP_CASTEiJ_G0031512
protein coding gene Chr7:80766443-80829550 (-)
CBA/J MGP_CBAJ_G0032151
protein coding gene Chr7:95597563-95660417 (-)
DBA/2J MGP_DBA2J_G0032304
protein coding gene Chr7:85394834-85451195 (-)
FVB/NJ MGP_FVBNJ_G0032261
protein coding gene Chr7:85266841-85325600 (-)
LP/J MGP_LPJ_G0032393
protein coding gene Chr7:90268895-90338061 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032294
protein coding gene Chr7:96276563-96360412 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032990
protein coding gene Chr7:88240088-88309044 (-)
PWK/PhJ MGP_PWKPhJ_G0031231
protein coding gene Chr7:78386185-78445152 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031074
protein coding gene Chr7:75434276-75494928 (-)
WSB/EiJ MGP_WSBEiJ_G0031629
protein coding gene Chr7:88866769-88927568 (-)



Homology
more
  • Human Ortholog
    FOLH1, folate hydrolase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FOLH1, folate hydrolase 1
    Orthology source: HGNC
  • Synonyms
    FGCP, FOLH, GCP2, GCPII, mGCP, NAALAD1, NAALAdase, PSM, PSMA
  • Links
    NCBI Gene ID: 2346
    neXtProt AC: NX_Q04609
    UniProt: Q04609

  • Chr Location
    11p11.12; chr11:49145094-49208706 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in protection from peripheral neuropathy and ischemic brain injury. Homozygotes for a null allele show increased food intake, anxiety-like behavior, smaller sciatic nerve axons, and impaired angiogenesis. Homozygotes for a different null allele show less neuron degeneration and astrocyte damage after traumatic brain injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001773 Ensembl Gene Model | MGI Sequence Detail 56967 C57BL/6J ±  kb
transcript ENSMUST00000001824 Ensembl | MGI Sequence Detail 3125 Not Applicable  
polypeptide ENSMUSP00000001824 Ensembl | MGI Sequence Detail 752 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 21
    Genomic 3
    cDNA 18

    Microarray probesets 3
References
more
  • Summaries
    All 61
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 37
  • Earliest
    J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
  • Latest
    J:258536 Caromile LA, et al., PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer. Sci Signal. 2017 Mar 14;10(470)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory