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Folh1
Gene Detail
 Symbol
Name
ID
Folh1
folate hydrolase 1
MGI:1858193
Synonyms GCP2, glutamate carboxypeptidase II, mopsm, prostate-specific membrane antigen
Feature Type protein coding gene
Genetic Map
Chromosome 7
48.51 cM, cytoband D1-D2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:86719352-86775864 bp, - strand
From VEGA annotation of GRCm38

  56513 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55826  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transferrin receptor
Gene Tree: Folh1

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in protection from peripheral neuropathy and ischemic brain injury. Mutant mice also exhibit increased food intake, increased anxiety-related behavior, smaller sciatic nerve axons, and impaired angiogenesis.
 
Interactions
Folh1 interacts with 82 markers (Mir1a-1, Mir1a-2, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process folic acid-containing compound metabolic process, metabolic process, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function carboxypeptidase activity, catalytic activity, ...
External Resources: FuncBase
Expression
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(2) cDNA(18)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037777 (Evidence)
Ensembl Gene ModelENSMUSG00000001773 (Evidence)
Entrez Gene53320 (Evidence)
UniGene269137
DFCITC1585449, TC1682421
DoTSDT.529032, DT.97355477
EC3.4.17.21
Consensus CDS ProjectCCDS21436.1, CCDS52300.1
International Mouse Knockout Project StatusFolh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037777 VEGA Gene Model | MGI Sequence Detail 56513 C57BL/6J ±  kb
transcript OTTMUST00000097517 VEGA | MGI Sequence Detail 2671 Not Applicable 
polypeptide OTTMUSP00000054708 VEGA | MGI Sequence Detail 752 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(848 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007484 Peptidase M28
InterPro IPR003137 Protease-associated domain, PA
InterPro IPR007365 Transferrin receptor-like, dimerisation domain
Protein Ontology PR:000007593 glutamate carboxypeptidase 2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:192324 Rahn KA, et al., Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis. Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20101-6
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory