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Usp2
Gene Detail
 Symbol
Name
ID
Usp2
ubiquitin specific peptidase 2
MGI:1858178
Synonyms B930035K21Rik, ubp41
Feature Type protein coding gene
Genetic Map
Chromosome 9
24.53 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:44067021-44095627 bp, + strand
From VEGA annotation of GRCm38

  28607 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3098  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Usp2

Human
homologs
Human Homolog USP2, ubiquitin specific peptidase 2
NCBI Gene ID 9099
neXtProt AC  NX_O75604
Human Synonyms  UBP41, USP9
Human Chr (Location)  11q23.3; chr11:119355215-119381726 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display severely reduced male fertility with defects in sperm motility.
 
Interactions
Usp2 interacts with 179 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cell cycle, muscle organ development, ...
Component cell cortex, centrosome, ...
Function cyclin binding, cysteine-type peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (22)    Tissues (14)    Images (19)
Theiler Stages: 1, 2, 3, 5, 22, 24, 26, 27, 28
Assay TypeResults
RNA in situ 12
RT-PCR 10
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(8) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000042086 (Evidence)
Ensembl Gene ModelENSMUSG00000032010 (Evidence)
Entrez Gene53376 (Evidence)
DFCITC1577175, TC1584176, TC1593966, TC1596783, TC1598825, TC1669125, TC1685052
DoTSDT.101139445, DT.532228, DT.55123582, DT.91283056, DT.91332303, DT.97341421, DT.97410386
EC3.4.19.12
Consensus CDS ProjectCCDS23094.1, CCDS23095.1
International Mouse Knockout Project StatusUsp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042086 VEGA Gene Model | MGI Sequence Detail 28607 C57BL/6J ±  kb
transcript OTTMUST00000110364 VEGA | MGI Sequence Detail 3867 Not Applicable 
polypeptide OTTMUSP00000061549 VEGA | MGI Sequence Detail 619 Not Applicable 

For the selected sequences
All sequences(94) RefSeq(20) UniProt(3)
Polymorphisms SNPs within 2kb(132 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2
InterPro IPR018200 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site
Protein Ontology PR:000017158 ubiquitin carboxyl-terminal hydrolase 2
References (Earliest) J:78123 Kameya S, et al., Mfrp, a gene encoding a frizzled related protein, is mutated in the mouse retinal degeneration 6. Hum Mol Genet. 2002 Aug 1;11(16):1879-86
(Latest) J:203824 Kitamura H, et al., Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation. FASEB J. 2013 Dec;27(12):4940-53
All references(44)
Other
accession IDs
MGI:2443236

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory