Tlr5
Gene Detail

Symbol Name ID

Tlr5 toll-like receptor 5 MGI:1858171

Feature Type

protein coding gene

Genetic Map

Chromosome 1

86.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr1:182954788-182976044 bp, + strand From NCBI annotation of GRCm38   21257 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20698  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: toll-like receptor 5
Gene Tree: Tlr5

Human homologs

Human Homolog		TLR5, toll-like receptor 5
NCBI Gene ID		7100
neXtProt AC		NX_O60602
Human Synonyms		SLEB1, TIL3
Human Chr (Location)		1q41-q42; chr1:223282748-223316624 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human TLR5

Alleles and phenotypes

All alleles(7) : Targeted(3) Gene trapped(4)
 

Mice homozygous for disruption of this gene have a generally normal phenotype. However they fail to respond immunologically to purified flagellin and are resistant to infection with Salmonella typhimurium.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	defense response to bacterium, inflammatory response, ...
Component	integral to membrane, membrane
Function	interleukin-1 receptor binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (23)    Tissues (23)    Images (3)
Theiler Stages: 14, 21, 28

Assay Type	Results
RNA in situ	21
RT-PCR	2

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(11) Primer pair(5)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000079164 (Evidence)
Entrez Gene	53791 (Evidence)
UniGene	116894
DFCI	TC1589961, TC1614032
DoTS	DT.111202534, DT.40150400, DT.94225152
NIA Mouse Gene Index	U001231
Consensus CDS Project	CCDS35815.1
International Mouse Knockout Project Status	Tlr5

Sequences

Length	Strain/Species
genomic	53791	NCBI Gene Model | MGI Sequence Detail	21257	C57BL/6J
transcript	NM_016928	RefSeq | MGI Sequence Detail	3211	C57BL/6
polypeptide	Q9JLF7	UniProt | EBI | MGI Sequence Detail	859	Not Applicable

All sequences(22) RefSeq(2) UniProt(4)

Polymorphisms

PCR(5) : SNPs(143 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000483	Cysteine-rich flanking region, C-terminal
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR003591	Leucine-rich repeat, typical subtype
InterPro	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
InterPro	IPR027176	Toll-like receptor 5
Protein Ontology	PR:000001156	toll-like receptor 5

Graphical View of Protein Domain Structure

References

(Earliest) J:61532 Sebastiani G, et al., Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice. Genomics. 2000 Mar 15;64(3):230-40
(Latest) J:193757 Zhang X, et al., Damaged spermatogenic cells induce inflammatory gene expression in mouse Sertoli cells through the activation of Toll-like receptors 2 and 4. Mol Cell Endocrinol. 2013 Jan 30;365(2):162-73
All references(101)