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Tlr5
Gene Detail
Symbol

Name
ID
Tlr5
toll-like receptor 5
MGI:1858171
Feature Type
protein coding gene
Genetic Map
Chromosome 1
86.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr1:182954788-182975994 bp, + strand
From VEGA annotation of GRCm38

  21207 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20698  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: TLR5
Protein SuperFamily: toll-like receptor 5
Gene Tree: Tlr5

Human
homologs
TLR5, toll-like receptor 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7100
neXtProt AC: NX_O60602

Human Synonyms: MELIOS, SLE1, SLEB1, TIL3

Human Chr (Location): 1q41-q42; chr1:223109404-223143282 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human TLR5

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene have a generally normal phenotype. However they fail to respond immunologically to purified flagellin and are resistant to infection with Salmonella typhimurium.
 
Interactions
Tlr5 interacts with 77 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process defense response to bacterium, immune system process, ...
Component integral component of membrane, membrane
Function interleukin-1 receptor binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (23)    Tissues (23)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 21
RT-PCR 2
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tlr5 ; ZFIN tlr5a    NEW 
Molecular
reagents
All nucleic(16) cDNA(11) Primer pair(5)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000050487 (Evidence)
Ensembl Gene Model ENSMUSG00000079164 (Evidence)
Entrez Gene 53791 (Evidence)
UniGene 116894
DFCI TC1589961, TC1614032
DoTS DT.94225152, DT.40150400, DT.111202534
NIA Mouse Gene Index U001231
Consensus CDS Project CCDS35815.1
International Mouse Phenotyping Consortium Status Tlr5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050487 VEGA Gene Model | MGI Sequence Detail 21207 C57BL/6J ±  kb
transcript OTTMUST00000128086 VEGA | MGI Sequence Detail 3818 Not Applicable 
polypeptide OTTMUSP00000068980 VEGA | MGI Sequence Detail 859 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(5)
Polymorphisms
PCR(5) : SNPs within 2kb(154 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
InterPro IPR027176 Toll-like receptor 5
Protein Ontology PR:000001156 Toll-like receptor 5
References
(Earliest) J:61532 Sebastiani G, et al., Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice. Genomics. 2000 Mar 15;64(3):230-40
(Latest) J:219843 Chassaing B, et al., Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015 Mar 5;519(7541):92-6
All references(111)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory