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Tlr5 Gene Detail
Summary
  • Symbol
    Tlr5
  • Name
    toll-like receptor 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858171
    NCBI Gene: 53791
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:182782353-182804010 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 86.12 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    676 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858171
 protein coding gene Chr1:182782317-182804010 (+)
129S1/SvImJ ENSMUSG00200022385
 protein coding gene Chr1:180550122-180571820 (+)
A/J ENSMUSG00195040020
 protein coding gene Chr1:180136629-180158287 (+)
AKR/J ENSMUSG00220020618
 protein coding gene Chr1:179381038-179402698 (+)
BALB/cJ ENSMUSG00180035698
 protein coding gene Chr1:180201502-180223200 (+)
C3H/HeJ ENSMUSG00175035810
 protein coding gene Chr1:180377143-180398841 (+)
C57BL/6NJ ENSMUSG00215016358
 protein coding gene Chr1:179596314-179617972 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015006
 protein coding gene Chr1:172953475-172974197 (+)
CAST/EiJ ENSTCUG00005039886
 protein coding gene Chr1:178118465-178140481 (+)
CBA/J ENSMUSG00210019030
 protein coding gene Chr1:180020492-180042185 (+)
DBA/2J ENSMUSG00185032901
 protein coding gene Chr1:184639905-184661592 (+)
FVB/NJ ENSMUSG00205031822
 protein coding gene Chr1:179071739-179093400 (+)
JF1/MsJ ENSUMUG00000004837
 protein coding gene Chr1:183655417-183677057 (+)
LP/J ENSMUSG00230022766
 protein coding gene Chr1:184209292-184230989 (+)
NOD/ShiLtJ ENSMUSG00190022888
 protein coding gene Chr1:180053007-180074665 (+)
NZO/HlLtJ ENSMUSG00225010489
 protein coding gene Chr1:187957307-187979028 (+)
PWK/PhJ ENSLUMG00010016371
 protein coding gene Chr1:178895577-178917236 (+)
SPRET/EiJ ENSMSPG00010028245
 protein coding gene Chr1:182400293-182407823 (+)
WSB/EiJ ENSIUOG00005011055
 protein coding gene Chr1:179242827-179264513 (+)



Homology
more
  • Human Ortholog
    TLR5, toll like receptor 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLR5, toll like receptor 5
  • Synonyms
    MELIOS, SLE1, SLEB1, TIL3
  • Links
    NCBI Gene ID: 7100
    UniProt: O60602

  • Chr Location
    1q41; chr1:223109339-223143318 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human TLR5 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 3 alleles in 7 genetic backgrounds
    10 phenotypes from multigenic genotypes
    141 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene have a generally normal phenotype. However they fail to respond immunologically to purified flagellin and are resistant to infection with Salmonella typhimurium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    632
  • Tissues
    29
  • cDNA Data
    12
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079164 Ensembl Gene Model | MGI Sequence Detail 21658 C57BL/6J ±  kb
    transcript ENSMUST00000193687 Ensembl | MGI Sequence Detail 2909 Not Applicable  
    polypeptide ENSMUSP00000141318 Ensembl | MGI Sequence Detail 873 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000001156 Toll-like receptor 5
      (term hierarchy)
    • InterPro Domains
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
      IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
      IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
      IPR017241 Toll-like receptor
    • GlyGen
      Q9JLF7 9 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 12
      Primer pair 6

      Microarray probesets 1
    References
    more
    • Summaries
      All 212
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 141
    • Earliest
      J:61532 Sebastiani G, et al., Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice. Genomics. 2000 Mar 15;64(3):230-40
    • Latest
      J:388717 Ritter J, et al., Hyaluronan Signaling Ameliorates the Epithelial Injury Response and Barrier Disruption After Ozone Exposure. Biomolecules. 2026 May 28;16(6)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory