About   Help   FAQ
Zpbp Gene Detail
Summary
  • Symbol
    Zpbp
  • Name
    zona pellucida binding protein
  • Synonyms
    4930486K01Rik, Sp38
  • Feature Type
    protein coding gene
  • IDs
    MGI:1855701
    NCBI Gene: 53604
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:11279626-11462408 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 6.76 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1855701
protein coding gene Chr11:11279624-11463230 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018043
protein coding gene Chr11:8561829-8739011 (-)
A/J MGP_AJ_G0018016
protein coding gene Chr11:8252082-8432743 (-)
AKR/J MGP_AKRJ_G0017980
protein coding gene Chr11:8603577-8792972 (-)
BALB/cJ MGP_BALBcJ_G0017984
protein coding gene Chr11:8279250-8456494 (-)
C3H/HeJ MGP_C3HHeJ_G0017797
protein coding gene Chr11:8515523-8695753 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018436
protein coding gene Chr11:8849323-9037117 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016094
protein coding gene Chr11:7841262-8006538 (-)
CAST/EiJ MGP_CASTEiJ_G0017359
protein coding gene Chr11:8533882-8714979 (-)
CBA/J MGP_CBAJ_G0017772
protein coding gene Chr11:9465040-9679235 (-)
DBA/2J MGP_DBA2J_G0017882
protein coding gene Chr11:8200105-8374383 (-)
FVB/NJ MGP_FVBNJ_G0017874
protein coding gene Chr11:8108402-8285833 (-)
LP/J MGP_LPJ_G0017953
protein coding gene Chr11:8676329-8841905 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017900
protein coding gene Chr11:9158984-9387301 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018476
protein coding gene Chr11:8629875-8811000 (-)
PWK/PhJ MGP_PWKPhJ_G0017139
protein coding gene Chr11:8238364-8405860 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016936
protein coding gene Chr11:8482073-8662920 (-)
WSB/EiJ MGP_WSBEiJ_G0017413
protein coding gene Chr11:8396575-8572157 (-)



Homology
more
  • Human Ortholog
    ZPBP, zona pellucida binding protein
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ZPBP, zona pellucida binding protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ZPBP1
  • Links
    NCBI Gene ID: 11055
    neXtProt AC: NX_Q9BS86
    UniProt: Q9BS86

  • Chr Location
    7p12.2; chr7:49846355-50093264 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    14 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice homozygous for a null mutation display infertility and asthenoglobozoospermia. Heterozygous males display an increase in the percentage of abnormal sperm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020193 Ensembl Gene Model | MGI Sequence Detail 182783 C57BL/6J ±  kb
transcript ENSMUST00000020413 Ensembl | MGI Sequence Detail 4248 Not Applicable  
polypeptide ENSMUSP00000020413 Ensembl | MGI Sequence Detail 408 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR013783 Immunoglobulin-like fold
    IPR010857 Zona-pellucida-binding
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 4
Other
Accession IDs
less
MGI:1922227
References
more
  • Summaries
    All 31
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:187685 Fujihara Y, et al., SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia. Development. 2012 Oct;139(19):3583-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/19/2019
MGI 6.13
The Jackson Laboratory