About   Help   FAQ
Vti1a
Gene Detail
 Symbol
Name
ID
Vti1a
vesicle transport through interaction with t-SNAREs 1A
MGI:1855699
Synonyms 1110014F16Rik, 1110018K19Rik, 4921537J05Rik, Vti1-rp2
Feature Type protein coding gene
Genetic Map
Chromosome 19
51.35 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:55316351-55626561 bp, + strand
From NCBI annotation of GRCm38

  310211 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:39963  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Vti1a

Human
homologs
Human Homolog VTI1A, vesicle transport through interaction with t-SNAREs 1A
NCBI Gene ID 143187
neXtProt AC  NX_Q96AJ9
Human Synonyms  MMDS3, MVti1, Vti1-rp2, VTI1RP2
Human Chr (Location)  10q25.2; chr10:112446998-112855364 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human VTI1A
Mutations,
alleles, and
phenotypes
All mutations/alleles(67) : Gene trapped(64) Targeted(3)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for a knock-out allele are viable and fertile.
 
Interactions
Vti1a interacts with 296 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process ER to Golgi vesicle-mediated transport, Golgi to vacuole transport, ...
Component clathrin-coated vesicle, endoplasmic reticulum membrane, ...
Function SNAP receptor activity, SNARE binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(18)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000024983 (Evidence)
Entrez Gene53611 (Evidence)
DFCITC1582339, TC1591047, TC1592843, TC1600312, TC1602265, TC1611746, TC1636373, TC1652383, TC1665167, TC1695170
DoTSDT.101201955, DT.101233873, DT.101356617, DT.101376055, DT.101735153, DT.40185891, DT.528101, DT.55126767, DT.55166918, DT.55267950, DT.55270773, DT.94246942, DT.94279015
NIA Mouse Gene IndexU060173, U069162, U171849
PDB1VCS
Consensus CDS ProjectCCDS29910.1
International Mouse Knockout Project StatusVti1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 53611 NCBI Gene Model | MGI Sequence Detail 310211 C57BL/6J ±  kb
transcript NM_001293685 RefSeq | MGI Sequence Detail 4620 C57BL/6 
polypeptide O89116 UniProt | EBI | MGI Sequence Detail 217 Not Applicable 

For the selected sequences
All sequences(89) RefSeq(32) UniProt(4)
Polymorphisms SNPs within 2kb(2448 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000727 Target SNARE coiled-coil domain
InterPro IPR010989 t-SNARE
InterPro IPR007705 Vesicle transport v-SNARE, N-terminal
Protein Ontology PR:000017358 vesicle transport through interaction with t-SNAREs homolog 1A
Graphical View of Protein Domain Structure
References (Earliest) J:45672 Lupashin VV, et al., Characterization of a novel yeast SNARE protein implicated in Golgi retrograde traffic. Mol Biol Cell. 1997 Dec;8(12):2659-76
(Latest) J:169107 Kunwar AJ, et al., Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2575-80
All references(41)
Other
accession IDs
MGI:1915752, MGI:1915845, MGI:1918188

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/16/2014
MGI 5.19
The Jackson Laboratory