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Vti1a Gene Detail
Summary
  • Symbol
    Vti1a
  • Name
    vesicle transport through interaction with t-SNAREs 1A
  • Synonyms
    1110014F16Rik, 1110018K19Rik, 4921537J05Rik, Vti1-rp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1855699
    NCBI Gene: 53611
  • Gene Overview
    MyGene.info: VTI1A
Location & Maps
more
  • Sequence Map
    Chr19:55316351-55626561 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      310211 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 51.35 cM, cytoband D2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    VTI1A, vesicle transport through interaction with t-SNAREs 1A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    VTI1A, vesicle transport through interaction with t-SNAREs 1A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MMDS3, MVti1, Vti1-rp2, VTI1RP2
  • Links
    NCBI Gene ID: 143187
    neXtProt AC: NX_Q96AJ9

  • Chr Location
    10q25.2; chr10:112446998-112855364 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    67
  • Gene trapped
    64
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for a knock-out allele are viable and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024983 Ensembl Gene Model | MGI Sequence Detail 310211 C57BL/6J ±  kb
transcript ENSMUST00000095950 Ensembl | MGI Sequence Detail 3405 Not Applicable  
polypeptide ENSMUSP00000093644 Ensembl | MGI Sequence Detail 217 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2430 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000017358 vesicle transport through interaction with t-SNAREs homolog 1A
  • PDB
  • InterPro Domains
    IPR027027 GOSR2/Membrin/Bos1
    IPR000727 Target SNARE coiled-coil homology domain
    IPR010989 t-SNARE
    IPR007705 Vesicle transport v-SNARE, N-terminal
Molecular
Reagents
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  • All nucleic 19
    cDNA 18
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGI:1915752, MGI:1915845, MGI:1918188
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:45672 Lupashin VV, et al., Characterization of a novel yeast SNARE protein implicated in Golgi retrograde traffic. Mol Biol Cell. 1997 Dec;8(12):2659-76
  • Latest
    J:213492 Walter AM, et al., The SNARE protein vti1a functions in dense-core vesicle biogenesis. EMBO J. 2014 Aug 1;33(15):1681-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory