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Reck Gene Detail
Summary
  • Symbol
    Reck
  • Name
    reversion-inducing-cysteine-rich protein with kazal motifs
  • Synonyms
    St15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1855698
    NCBI Gene: 53614
  • Gene Overview
    MyGene.info: RECK
Location & Maps
more
  • Sequence Map
    Chr4:43875530-43944806 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      69277 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 23.05 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RECK, reversion inducing cysteine rich protein with kazal motifs
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RECK, reversion inducing cysteine rich protein with kazal motifs
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ST15
  • Links
    NCBI Gene ID: 8434
    neXtProt AC: NX_O95980

  • Chr Location
    9p13.3; chr9:36036913-36124455 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9622
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: RECK
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 4 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically and radiation induced
    1
  • Gene trapped
    1
  • Targeted
    7
  • Genomic Mutations
    1 involving Reck
  • Incidental Mutations
Homozygous mutation of this gene results in lethality around E10.5-E11.5, defects in collagen fibrils, basal lamina and vascular development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007127 VEGA Gene Model | MGI Sequence Detail 69277 C57BL/6J ±  kb
transcript OTTMUST00000016461 VEGA | MGI Sequence Detail 4433 Not Applicable  
polypeptide OTTMUSP00000007546 VEGA | MGI Sequence Detail 971 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    615 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013859 reversion-inducing cysteine-rich protein with Kazal motifs
  • InterPro Domains
    IPR002350 Kazal domain
Molecular
Reagents
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  • All nucleic 31
    cDNA 31

    Microarray probesets 3
References
more
  • Summaries
    All 44
    Developmental Gene Expression 12
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:50571 Takahashi C, et al., Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13221-6
  • Latest
    J:223602 Kim CW, et al., Prevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice. Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1412-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory