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Reck
Gene Detail
 Symbol
Name
ID
Reck
reversion-inducing-cysteine-rich protein with kazal motifs
MGI:1855698
Synonyms St15
Feature Type protein coding gene
Genetic Map
Chromosome 4
23.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:43875530-43944806 bp, + strand
From VEGA annotation of GRCm38

  69277 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9622  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Reck

Human
homologs
Human Homolog RECK, reversion-inducing-cysteine-rich protein with kazal motifs
NCBI Gene ID 8434
neXtProt AC  NX_O95980
Human Synonyms  ST15
Human Chr (Location)  9p13.3; chr9:36036913-36124457 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in lethality around E10.5-E11.5, defects in collagen fibrils, basal lamina and vascular development.
 
Interactions
Reck interacts with 298 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process blood vessel maturation, embryo implantation, ...
Component anchored component of membrane, membrane, ...
Function endopeptidase inhibitor activity, peptidase inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (41)    Tissues (38)    Images (10)
Theiler Stages: 17, 21, 22
Assay TypeResults
Immunohistochemistry 5
RNA in situ 36
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) cDNA(31)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000007127 (Evidence)
Ensembl Gene ModelENSMUSG00000028476 (Evidence)
Entrez Gene53614 (Evidence)
UniGene331573
DFCITC1583925, TC1600462, TC1723761
DoTSDT.101724169, DT.484633, DT.94232377
NIA Mouse Gene IndexU004252
Consensus CDS ProjectCCDS18116.1
International Mouse Knockout Project StatusReck
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007127 VEGA Gene Model | MGI Sequence Detail 69277 C57BL/6J ±  kb
transcript OTTMUST00000016461 VEGA | MGI Sequence Detail 4433 Not Applicable 
polypeptide OTTMUSP00000007546 VEGA | MGI Sequence Detail 971 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(617 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002350 Kazal domain
Protein Ontology PR:000013859 reversion-inducing cysteine-rich protein with Kazal motifs
References (Earliest) J:50571 Takahashi C, et al., Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13221-6
(Latest) J:211881 Peng X, et al., Activation of farnesoid X receptor induces RECK expression in mouse liver. Biochem Biophys Res Commun. 2014 Jan 3;443(1):211-6
All references(46)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory