About   Help   FAQ
Reck
Gene Detail
Symbol

Name
ID
Reck
reversion-inducing-cysteine-rich protein with kazal motifs
MGI:1855698
Synonyms
St15
Feature Type
protein coding gene
Genetic Map
Chromosome 4
23.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:43875530-43944806 bp, + strand
From VEGA annotation of GRCm38

  69277 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9622  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: RECK
Gene Tree: Reck

Human
homologs
RECK, reversion-inducing-cysteine-rich protein with kazal motifs
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8434
neXtProt AC: NX_O95980

Human Synonyms: ST15

Human Chr (Location): 9p13.3; chr9:36036913-36124455 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in lethality around E10.5-E11.5, defects in collagen fibrils, basal lamina and vascular development.
 
Interactions
Reck interacts with 298 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process blood vessel maturation, embryo implantation, ...
Component anchored component of membrane, membrane, ...
Function endopeptidase inhibitor activity, peptidase inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (41)    Tissues (38)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 36
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase reck ; ZFIN reck    NEW 
Molecular
reagents
All nucleic(31) cDNA(31)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000007127 (Evidence)
Ensembl Gene Model ENSMUSG00000028476 (Evidence)
Entrez Gene 53614 (Evidence)
UniGene 331573
DFCI TC1600462, TC1583925, TC1723761
DoTS DT.94232377, DT.484633, DT.101724169
NIA Mouse Gene Index U004252
Consensus CDS Project CCDS18116.1
International Mouse Phenotyping Consortium Status Reck
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007127 VEGA Gene Model | MGI Sequence Detail 69277 C57BL/6J ±  kb
transcript OTTMUST00000016461 VEGA | MGI Sequence Detail 4433 Not Applicable 
polypeptide OTTMUSP00000007546 VEGA | MGI Sequence Detail 971 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(617 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002350 Kazal domain
Protein Ontology PR:000013859 reversion-inducing cysteine-rich protein with Kazal motifs
References
(Earliest) J:50571 Takahashi C, et al., Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13221-6
(Latest) J:211881 Peng X, et al., Activation of farnesoid X receptor induces RECK expression in mouse liver. Biochem Biophys Res Commun. 2014 Jan 3;443(1):211-6
All references(45)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory