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Nap1l1 Gene Detail
Summary
  • Symbol
    Nap1l1
  • Name
    nucleosome assembly protein 1-like 1
  • Synonyms
    D10Ertd68e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1855693
    NCBI Gene: 53605
  • Gene Overview
    MyGene.info: NAP1L1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:111473223-111498150 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 58.67 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1855693
protein coding gene Chr10:111473191-111498150 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017721
protein coding gene Chr10:113890133-113919558 (+)
A/J MGP_AJ_G0017698
protein coding gene Chr10:109561096-109586847 (+)
AKR/J MGP_AKRJ_G0017660
protein coding gene Chr10:112761896-112786735 (+)
BALB/cJ MGP_BALBcJ_G0017662
protein coding gene Chr10:109963003-109987586 (+)
C3H/HeJ MGP_C3HHeJ_G0017487
protein coding gene Chr10:112912440-112937819 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018119
protein coding gene Chr10:117823939-117848878 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015798
protein coding gene Chr10:104422719-104447986 (+)
CAST/EiJ MGP_CASTEiJ_G0017048
protein coding gene Chr10:113073312-113100271 (+)
CBA/J MGP_CBAJ_G0017456
protein coding gene Chr10:122455233-122480176 (+)
DBA/2J MGP_DBA2J_G0017561
protein coding gene Chr10:108697878-108721661 (+)
FVB/NJ MGP_FVBNJ_G0017555
protein coding gene Chr10:107684649-107712657 (+)
LP/J MGP_LPJ_G0017635
protein coding gene Chr10:114541582-114566785 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017584
protein coding gene Chr10:125063007-125088990 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018157
protein coding gene Chr10:112788779-112813555 (+)
PWK/PhJ MGP_PWKPhJ_G0016830
protein coding gene Chr10:108778330-108803731 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016620
protein coding gene Chr10:111530186-111558717 (+)
WSB/EiJ MGP_WSBEiJ_G0017108
protein coding gene Chr10:112916952-112941817 (+)



Homology
more
  • Human Ortholog
    NAP1L1, nucleosome assembly protein 1 like 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NAP1L1, nucleosome assembly protein 1 like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NAP1, NAP1L, NRP
  • Links
    NCBI Gene ID: 4673
    neXtProt AC: NX_P55209
    UniProt: P55209

  • Chr Location
    12q21.2; chr12:76045383-76085033 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a homozygous mutation exhibit prenatal lethality and impaired neural progenitor cell proliferation and differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058799 Ensembl Gene Model | MGI Sequence Detail 24928 C57BL/6J ±  kb
transcript ENSMUST00000217908 Ensembl | MGI Sequence Detail 1350 Not Applicable  
polypeptide ENSMUSP00000151750 Ensembl | MGI Sequence Detail 391 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR037231 NAP-like superfamily
    IPR002164 Nucleosome assembly protein (NAP)
Molecular
Reagents
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  • All nucleic 32
    cDNA 30
    Primer pair 2

    Microarray probesets 11
Other
Accession IDs
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MGI:1098627, MGI:2141803, MGI:2143550
References
more
  • Summaries
    All 49
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:263406 Qiao H, et al., Nap1l1 Controls Embryonic Neural Progenitor Cell Proliferation and Differentiation in the Developing Brain. Cell Rep. 2018 Feb 27;22(9):2279-2293

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory