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Nono
Gene Detail
Symbol

Name
ID
Nono
non-POU-domain-containing, octamer binding protein
MGI:1855692
Synonyms
P54NRB
Feature Type
protein coding gene
Genetic Map
Chromosome X
44.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:101429318-101448591 bp, + strand
From VEGA annotation of GRCm38

  19274 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7212  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NONO
Gene Tree: Nono

Human
homologs
NONO, non-POU domain containing, octamer-binding
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4841
neXtProt AC: NX_Q15233

Human Synonyms: NMT55, NRB54, P54, P54NRB, PPP1R114

Human Chr (Location): Xq13.1; chrX:71283192-71301168 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(113) : Gene trapped(113)
 
Mice carrying a gene trap trap allele show shortening of the cercarian period under constant dark conditions. Chimeras for some other gene trap alleles may display gastrulation defects.
 
Phenotype Images(36)
Interactions
Nono interacts with 183 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cellular response to DNA damage stimulus, circadian rhythm, ...
Component membrane, nuclear matrix, ...
Function core promoter binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (24)    Tissues (24)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 22
RT-PCR 2
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nono ; ZFIN nono    NEW 
Molecular
reagents
All nucleic(20) cDNA(18) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000018195 (Evidence)
Ensembl Gene Model ENSMUSG00000031311 (Evidence)
Entrez Gene 53610 (Evidence)
DFCI TC1587967, TC1573858
DoTS DT.94195741, DT.55146652, DT.111024620, DT.101398029, DT.536452, DT.111024645, DT.97392017, DT.94195831
NIA Mouse Gene Index U020068, U087232, U094470
PDB 2CPJ, 2RS8
Consensus CDS Project CCDS30316.1
International Mouse Phenotyping Consortium Status Nono
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018195 VEGA Gene Model | MGI Sequence Detail 19274 C57BL/6J ±  kb
transcript OTTMUST00000043923 VEGA | MGI Sequence Detail 2562 Not Applicable 
polypeptide OTTMUSP00000019724 VEGA | MGI Sequence Detail 473 Not Applicable 

For the selected sequences
All sequences(89) RefSeq(8) UniProt(8)
Polymorphisms
SNPs within 2kb(42 from dbSNP Build 137)    SNPs within 2kb including multiple locations(46)
Protein-related
information
ResourceIDDescription
InterPro IPR012975 NOPS
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000011320 non-POU domain-containing octamer-binding protein
References
(Earliest) J:24184 Yang YS, et al., NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss. Mol Cell Biol. 1993 Sep;13(9):5593-603
(Latest) J:218106 Li S, et al., Double-strand break repair deficiency in NONO knockout murine embryonic fibroblasts and compensation by spontaneous upregulation of the PSPC1 paralog. Nucleic Acids Res. 2014 Sep;42(15):9771-80
All references(53)
Other
accession IDs
MGI:2139550, MGI:3034758

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory