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Nono
Gene Detail
 Symbol
Name
ID
Nono
non-POU-domain-containing, octamer binding protein
MGI:1855692
Synonyms P54NRB
Feature Type protein coding gene
Genetic Map
Chromosome X
44.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:101429318-101448591 bp, + strand
From VEGA annotation of GRCm38

  19274 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7212  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nono

Human
homologs
Human Homolog NONO, non-POU domain containing, octamer-binding
NCBI Gene ID 4841
neXtProt AC  NX_Q15233
Human Synonyms  NMT55, NRB54, P54, P54NRB, PPP1R114
Human Chr (Location)  Xq13.1; chrX:71283192-71301168 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(113) : Gene trapped(113)
 
Mice carrying a gene trap trap allele show shortening of the cercarian period under constant dark conditions. Chimeras for some other gene trap alleles may display gastrulation defects.
 
Phenotype Images(36)
Interactions
Nono interacts with 183 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cellular response to DNA damage stimulus, circadian rhythm, ...
Component membrane, nuclear matrix, ...
Function core promoter binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (24)    Tissues (24)    Images (4)
Theiler Stages: 21, 23, 27
Assay TypeResults
RNA in situ 22
RT-PCR 2
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(18) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000018195 (Evidence)
Ensembl Gene ModelENSMUSG00000031311 (Evidence)
Entrez Gene53610 (Evidence)
DFCITC1573858, TC1587967
DoTSDT.101398029, DT.111024620, DT.111024645, DT.536452, DT.55146652, DT.94195741, DT.94195831, DT.97392017
NIA Mouse Gene IndexU020068, U087232, U094470
PDB2CPJ, 2RS8
Consensus CDS ProjectCCDS30316.1
International Mouse Knockout Project StatusNono
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018195 VEGA Gene Model | MGI Sequence Detail 19274 C57BL/6J ±  kb
transcript OTTMUST00000043923 VEGA | MGI Sequence Detail 2562 Not Applicable 
polypeptide OTTMUSP00000019724 VEGA | MGI Sequence Detail 473 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(6) UniProt(8)
Polymorphisms SNPs within 2kb(42 from dbSNP Build 137)    SNPs within 2kb including multiple locations(46)
Protein-related
information
ResourceIDDescription
InterPro IPR012975 NOPS
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000011320 non-POU domain-containing octamer-binding protein
References (Earliest) J:24184 Yang YS, et al., NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss. Mol Cell Biol. 1993 Sep;13(9):5593-603
(Latest) J:193286 Kowalska E, et al., Feature Article: NONO couples the circadian clock to the cell cycle. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1592-9
All references(51)
Other
accession IDs
MGI:2139550, MGI:3034758

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory