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Map3k6
Gene Detail
Symbol

Name
ID
Map3k6
mitogen-activated protein kinase kinase kinase 6
MGI:1855691
Synonyms
Ask2, MAPKKK6, MEKK6
Feature Type
protein coding gene
Genetic Map
Chromosome 4
66.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:133240818-133252929 bp, + strand
From VEGA annotation of GRCm38

  12112 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3435  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: MAPKKK 5-like kinase
Gene Tree: Map3k6

Human
homologs
Human Homolog MAP3K6, mitogen-activated protein kinase kinase kinase 6
NCBI Gene ID 9064
neXtProt AC  NX_O95382
Human Synonyms  ASK2, MAPKKK6, MEKK6
Human Chr (Location)  1p36.11; chr1:27355179-27367054 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous and heterozygous null mice display an increased incidence of chemically induced skin tumors and homozygous mice also show resistance to induced apoptosis.
 
Interactions
Map3k6 interacts with 48 markers (Mir22, Mir124a-1, Mir124a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process activation of MAPKK activity, intracellular signal transduction, ...
Component cytoplasm
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (78)    Tissues (65)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 78
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(27)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000010479 (Evidence)
Ensembl Gene ModelENSMUSG00000028862 (Evidence)
Entrez Gene53608 (Evidence)
UniGene36640
DFCITC1583361
DoTSDT.527181, DT.91438286
NIA Mouse Gene IndexU004915
EC2.7.11.25
Consensus CDS ProjectCCDS18744.1
International Mouse Knockout Project StatusMap3k6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010479 VEGA Gene Model | MGI Sequence Detail 12112 C57BL/6J ±  kb
transcript OTTMUST00000024413 VEGA | MGI Sequence Detail 4334 Not Applicable 
polypeptide OTTMUSP00000011233 VEGA | MGI Sequence Detail 1291 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(192 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025136 Domain of unknown function DUF4071
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR013761 Sterile alpha motif/pointed domain
Protein Ontology PR:000010139 mitogen-activated protein kinase kinase kinase 6
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:174387 Zhou X, et al., Rac1/osmosensing scaffold for MEKK3 contributes via phospholipase C-{gamma}1 to activation of the osmoprotective transcription factor NFAT5. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12155-60
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory