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Map3k6 Gene Detail
Summary
  • Symbol
    Map3k6
  • Name
    mitogen-activated protein kinase kinase kinase 6
  • Synonyms
    Ask2, MAPKKK6, MEKK6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1855691
    NCBI Gene: 53608
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:133240818-133252929 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 66.25 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    195 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1855691
protein coding gene Chr4:133239657-133252929 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028889
protein coding gene Chr4:135475570-135487496 (+)
A/J MGP_AJ_G0028848
protein coding gene Chr4:129810359-129822413 (+)
AKR/J MGP_AKRJ_G0028801
protein coding gene Chr4:133492776-133504830 (+)
BALB/cJ MGP_BALBcJ_G0028871
protein coding gene Chr4:130431492-130443541 (+)
C3H/HeJ MGP_C3HHeJ_G0028585
protein coding gene Chr4:133744389-133756443 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029313
protein coding gene Chr4:140346661-140358742 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026584
protein coding gene Chr4:122891500-122903509 (+)
CAST/EiJ MGP_CASTEiJ_G0028018
protein coding gene Chr4:131853555-131865626 (+)
CBA/J MGP_CBAJ_G0028551
protein coding gene Chr4:144001082-144013134 (+)
DBA/2J MGP_DBA2J_G0028700
protein coding gene Chr4:130230935-130242988 (+)
FVB/NJ MGP_FVBNJ_G0028667
protein coding gene Chr4:129102581-129115757 (+)
LP/J MGP_LPJ_G0028801
protein coding gene Chr4:135604908-135616969 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028693
protein coding gene Chr4:148527912-148539978 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029351
protein coding gene Chr4:133912453-133924516 (+)
PWK/PhJ MGP_PWKPhJ_G0027739
protein coding gene Chr4:126940879-126953043 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027565
protein coding gene Chr4:129756516-129768613 (+)
WSB/EiJ MGP_WSBEiJ_G0028098
protein coding gene Chr4:134086147-134098189 (+)



Homology
more
  • Human Ortholog
    MAP3K6, mitogen-activated protein kinase kinase kinase 6
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MAP3K6, mitogen-activated protein kinase kinase kinase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASK2, MAPKKK6, MEKK6
  • Links
    NCBI Gene ID: 9064
    neXtProt AC: NX_O95382
    UniProt: O95382

  • Chr Location
    1p36.11; chr1:27355179-27368037 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous and heterozygous null mice display an increased incidence of chemically induced skin tumors and homozygous mice also show resistance to induced apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028862 Ensembl Gene Model | MGI Sequence Detail 12112 C57BL/6J ±  kb
transcript ENSMUST00000030677 Ensembl | MGI Sequence Detail 4334 Not Applicable  
polypeptide ENSMUSP00000030677 Ensembl | MGI Sequence Detail 1291 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • EC
  • InterPro Domains
    IPR025136 Domain of unknown function DUF4071
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
    IPR013761 Sterile alpha motif/pointed domain superfamily
Molecular
Reagents
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  • All nucleic 28
    cDNA 28

    Microarray probesets 4
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:262879 Tartey S, et al., ASK1/2 signaling promotes inflammation in a mouse model of neutrophilic dermatosis. J Clin Invest. 2018 May 1;128(5):2042-2047

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory