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Vti1b Gene Detail
Summary
  • Symbol
    Vti1b
  • Name
    vesicle transport through interaction with t-SNAREs 1B
  • Synonyms
    Vti1-rp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1855688
    NCBI Gene: 53612
  • Gene Overview
    MyGene.info: VTI1B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:79156017-79172667 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16651 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 35.51 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    VTI1B, vesicle transport through interaction with t-SNAREs 1B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VTI1B, vesicle transport through interaction with t-SNAREs 1B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    v-SNARE, VTI1, VTI1L, VTI1-LIKE, vti1-rp1, VTI2
  • Links
    NCBI Gene ID: 10490
    neXtProt AC: NX_Q9UEU0
    UniProt: Q9UEU0

  • Chr Location
    14q24.1; chr14:67651149-67674885 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 38178
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: VTI1B
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    28 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
While the majority of homozygous mutant mice are of normal size, some show reduced weight. A portion of these smaller mice died within 6 weeks of life. Liver cysts were identified in some of the mutant mice that were of normal size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000034944 VEGA Gene Model | MGI Sequence Detail 16651 C57BL/6J ±  kb
    transcript OTTMUST00000088840 VEGA | MGI Sequence Detail 1490 Not Applicable  
    polypeptide OTTMUSP00000048478 VEGA | MGI Sequence Detail 232 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      156 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • PDB
    • InterPro Domains
      IPR010989 SNARE
      IPR000727 Target SNARE coiled-coil homology domain
      IPR007705 Vesicle transport v-SNARE, N-terminal
      IPR038407 Vesicle transport v-SNARE, N-terminal domain superfamily
    Molecular
    Reagents
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    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144935
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Gene Ontology 12
      Phenotypes 12
    • Earliest
      J:45672 Lupashin VV, et al., Characterization of a novel yeast SNARE protein implicated in Golgi retrograde traffic. Mol Biol Cell. 1997 Dec;8(12):2659-76
    • Latest
      J:255769 Wu SJ, et al., A Critical Analysis of the Role of SNARE Protein SEC22B in Antigen Cross-Presentation. Cell Rep. 2017 Jun 27;19(13):2645-2656

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory