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Vti1b
Gene Detail
Symbol

Name
ID
Vti1b
vesicle transport through interaction with t-SNAREs 1B
MGI:1855688
Synonyms
Vti1-rp1
Feature Type
protein coding gene
Genetic Map
Chromosome 12
35.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:79156017-79172667 bp, - strand
From VEGA annotation of GRCm38

  16651 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38178  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Vti1b

Human
homologs
Human Homolog VTI1B, vesicle transport through interaction with t-SNAREs 1B
NCBI Gene ID 10490
neXtProt AC  NX_Q9UEU0
Human Synonyms  v-SNARE, VTI1, VTI1L, VTI1-LIKE, vti1-rp1, VTI2
Human Chr (Location)  14q24.1; chr14:67651149-67674885 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from APF )
 
While the majority of homozygous mutant mice are of normal size, some show reduced weight. A portion of these smaller mice died within 6 weeks of life. Liver cysts were identified in some of the mutant mice that were of normal size.
 
Interactions
Vti1b interacts with 147 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process ER to Golgi vesicle-mediated transport, Golgi to vacuole transport, ...
Component cytoplasm, endoplasmic reticulum membrane, ...
Function chloride channel inhibitor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (42)    Tissues (8)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 42
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034944 (Evidence)
Ensembl Gene ModelENSMUSG00000021124 (Evidence)
Entrez Gene53612 (Evidence)
DFCITC1578964, TC1687439
NIA Mouse Gene IndexU034112
PDB2QYW, 1GL2
Consensus CDS ProjectCCDS26008.1
International Mouse Knockout Project StatusVti1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034944 VEGA Gene Model | MGI Sequence Detail 16651 C57BL/6J ±  kb
transcript OTTMUST00000088840 VEGA | MGI Sequence Detail 1490 Not Applicable 
polypeptide OTTMUSP00000048478 VEGA | MGI Sequence Detail 232 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(4) UniProt(13)
Polymorphisms
SNPs within 2kb(158 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000727 Target SNARE coiled-coil domain
InterPro IPR010989 t-SNARE
InterPro IPR007705 Vesicle transport v-SNARE, N-terminal
Protein Ontology PR:000017359 vesicle transport through interaction with t-SNAREs homolog 1B
References
(Earliest) J:45672 Lupashin VV, et al., Characterization of a novel yeast SNARE protein implicated in Golgi retrograde traffic. Mol Biol Cell. 1997 Dec;8(12):2659-76
(Latest) J:213492 Walter AM, et al., The SNARE protein vti1a functions in dense-core vesicle biogenesis. EMBO J. 2014 Aug 1;33(15):1681-97
All references(42)
Other
accession IDs
MGI:2144935

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory