Tsnax MGI Mouse Gene Detail - MGI:1855672 - translin-associated factor X

Symbol

Tsnax
Name

translin-associated factor X
Synonyms

Trax

Feature Type

protein coding gene
IDs

MGI:1855672
NCBI Gene: 53424
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:125739780-125760947 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 73.10 cM
Mapping Data

4 experiments

SNPs within 2kb

540 from dbSNP Build 142
Strain Annotations

19
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1855672	protein coding gene	Chr8:125739736-125760947 (+)
129S1/SvImJ	ENSMUSG00200041534	protein coding gene	Chr8:119992485-120013630 (+)
A/J	ENSMUSG00195025727	protein coding gene	Chr8:120269386-120286800 (+)
AKR/J	ENSMUSG00220042180	protein coding gene	Chr8:120463339-120483878 (+)
BALB/cJ	ENSMUSG00180022845	protein coding gene	Chr8:120314222-120331633 (+)
C3H/HeJ	ENSMUSG00175027749	protein coding gene	Chr8:120382749-120403287 (+)
C57BL/6NJ	ENSMUSG00215017135	protein coding gene	Chr8:119971669-119992770 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031718	protein coding gene	Chr8:116150146-116168024 (+)
CAST/EiJ	ENSTCUG00005029851	protein coding gene	Chr8:119719018-119736329 (+)
CBA/J	ENSMUSG00210031812	protein coding gene	Chr8:120297621-120318724 (+)
DBA/2J	ENSMUSG00185036165	protein coding gene	Chr8:126616583-126637728 (+)
FVB/NJ	ENSMUSG00205030834	protein coding gene	Chr8:119270386-119291532 (+)
JF1/MsJ	ENSUMUG00000032611	protein coding gene	Chr8:128815367-128832778 (+)
LP/J	ENSMUSG00230023632	protein coding gene	Chr8:130175089-130196234 (+)
NOD/ShiLtJ	ENSMUSG00190020075	protein coding gene	Chr8:120411245-120431823 (+)
NZO/HlLtJ	ENSMUSG00225019804	protein coding gene	Chr8:133534544-133555688 (+)
PWK/PhJ	ENSLUMG00010036147	protein coding gene	Chr8:120106431-120123892 (+)
SPRET/EiJ	ENSMSPG00010001736	protein coding gene	Chr8:122287567-122304564 (+)
WSB/EiJ	ENSIUOG00005028551	protein coding gene	Chr8:121085524-121106669 (+)

Human Ortholog

TSNAX, translin associated factor X

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TSNAX, translin associated factor X
Synonyms

C3PO, TRAX
Links

HGNC:12380

NCBI Gene ID: 7257

UniProt: Q99598
Chr Location

1q42.2; chr1:231528541-231566524 (+) GRCh38

MGI Vertebrate Homology

Tsnax stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TSNAX
Gene Tree

Tsnax

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

6
Gene trapped

4
Targeted

3
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit impaired DNA repair and increased cell death in UV-C treated MEFs.

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All GO Annotations

44
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

937
Tissues

17
cDNA Data

14
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tsnax

ZFIN tsnax

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All Sequences

55
RefSeq

2
UniProt

3
CCDS

CCDS22778.1

Ensembl

ENSMUSG00000056820 (Evidence)
NCBI Gene

53424

			Length	Strain/Species	Flank
genomic	53424	NCBI Gene Model \| MGI Sequence Detail	21168	C57BL/6J	± kb
transcript	NM_016909	RefSeq \| MGI Sequence Detail	2363	ZRU/MplStud
polypeptide	Q9QZE7	UniProt \| EBI \| MGI Sequence Detail	290	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016732 translin-associated protein X

(term hierarchy)
InterPro Domains

IPR016069 Translin, C-terminal

IPR002848 Translin family

IPR016068 Translin, N-terminal

IPR036081 Translin superfamily
GlyGen

Q9QZE7 1 site

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All nucleic 19

Genomic 3

cDNA 15

Primer pair 1

Microarray probesets 6

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MGI:2142892

Summaries

All 54

Developmental Gene Expression 1

Gene Ontology 13

Phenotypes 15
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:387928 Liu Y, et al., Conditional Deletion of Translin/Trax in Dopaminergic Neurons Reveals No Impact on Psychostimulant Behaviors or Adiposity. Biomolecules. 2025 Jul 17;15(7)

TSS for Tsnax:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr80064	Chr8:125739667-125739687 (+)	-103 bp
Tssr80065	Chr8:125739691-125739714 (+)	-77 bp
Tssr80066	Chr8:125739725-125739745 (+)	-45 bp
Tssr80067	Chr8:125739772-125739834 (+)	23 bp
Tssr80068	Chr8:125739836-125739847 (+)	62 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24