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Tmod2
Gene Detail
 Symbol
Name
ID
Tmod2
tropomodulin 2
MGI:1355335
Synonyms neural tropomodulin, N-Tmod, NTMOD
Feature Type protein coding gene
Genetic Map
Chromosome 9
42.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:75565621-75611325 bp, - strand
From NCBI annotation of GRCm38

  45705 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22817  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tropomodulin
Gene Tree: Tmod2

Human
homologs
Human Homolog TMOD2, tropomodulin 2 (neuronal)
NCBI Gene ID 29767
neXtProt AC  NX_Q9NZR1
Human Synonyms  NTMOD, N-TMOD
Human Chr (Location)  15q21.2; chr15:51751561-51816363 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in enhanced LTP, hyperactivity, impaired startle response, and impaired learning.
 
Interactions
Tmod2 interacts with 560 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process learning or memory, neuron-neuron synaptic transmission, ...
Component cytoplasm, cytoskeleton, ...
Function actin binding, tropomyosin binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (6)    Tissues (6)   
Theiler Stages: 10, 18, 20, 23, 25
Assay TypeResults
RNA in situ 2
Northern blot 4
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(1) Other(1)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000032186 (Evidence)
Entrez Gene50876 (Evidence)
DFCITC1575076, TC1589078, TC1598593, TC1676995, TC1720615
DoTSDT.101380432, DT.110638895, DT.40134046, DT.55126270, DT.55236191, DT.91337113, DT.94190247, DT.99854075
NIA Mouse Gene IndexU031100
Consensus CDS ProjectCCDS23345.1
International Mouse Knockout Project StatusTmod2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 50876 NCBI Gene Model | MGI Sequence Detail 45705 C57BL/6J ±  kb
transcript NM_001038710 RefSeq | MGI Sequence Detail 9957 C57BL/6 
polypeptide Q9JKK7 UniProt | EBI | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(8) UniProt(1)
Polymorphisms SNPs within 2kb(428 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004934 Tropomodulin
Protein Ontology PR:000016445 tropomodulin-2
Graphical View of Protein Domain Structure
References (Earliest) J:60558 Cox PR, et al., Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs. Genomics. 2000 Jan 1;63(1):97-107
(Latest) J:208725 Sui Z, et al., Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver. Blood. 2014 Jan 30;123(5):758-67
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory