About   Help   FAQ
Tmod2
Gene Detail
Symbol

Name
ID
Tmod2
tropomodulin 2
MGI:1355335
Synonyms
neural tropomodulin, N-Tmod, NTMOD
Feature Type
protein coding gene
Genetic Map
Chromosome 9
42.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:75565621-75611325 bp, - strand
From Ensembl annotation of GRCm38

  45705 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22817  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TMOD2
Protein SuperFamily: tropomodulin
Gene Tree: Tmod2

Human
homologs
TMOD2, tropomodulin 2 (neuronal)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 29767
neXtProt AC: NX_Q9NZR1

Human Synonyms: NTMOD, N-TMOD

Human Chr (Location): 15q21.2; chr15:51751561-51816363 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in enhanced LTP, hyperactivity, impaired startle response, and impaired learning.
 
Interactions
Tmod2 interacts with 559 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process actin filament organization, learning or memory, ...
Component cytoplasm, cytoskeleton, ...
Function actin binding, tropomyosin binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (6)    Tissues (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
Northern blot 4
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TMOD2 ; Xenbase tmod2    NEW 
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(1) Other(1)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000032186 (Evidence)
Entrez Gene 50876 (Evidence)
DFCI TC1720615, TC1575076, TC1676995, TC1598593, TC1589078
DoTS DT.94190247, DT.99854075, DT.91337113, DT.55236191, DT.101380432, DT.55126270, DT.110638895, DT.40134046
NIA Mouse Gene Index U031100
Consensus CDS Project CCDS23345.1
International Mouse Phenotyping Consortium Status Tmod2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032186 Ensembl Gene Model | MGI Sequence Detail 45705 C57BL/6J ±  kb
transcript ENSMUST00000064433 Ensembl | MGI Sequence Detail 9893 Not Applicable 
polypeptide ENSMUSP00000069956 Ensembl | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(428 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004934 Tropomodulin
Protein Ontology PR:000016445 tropomodulin-2
References
(Earliest) J:60558 Cox PR, et al., Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs. Genomics. 2000 Jan 1;63(1):97-107
(Latest) J:208725 Sui Z, et al., Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver. Blood. 2014 Jan 30;123(5):758-67
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory