Mink1 MGI Mouse Gene Detail - MGI:1355329 - misshapen-like kinase 1 (zebrafish)

Symbol

Mink1
Name

misshapen-like kinase 1 (zebrafish)
Synonyms

Map4k6, MINK, Misshapen/NIKs-related kinase, Ysk2

Feature Type

protein coding gene
IDs

MGI:1355329
NCBI Gene: 50932
Gene Overview

MyGene.info: MINK1
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:70562881-70614483 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 43.00 cM, cytoband B4
Mapping Data

1 experiment

SNPs within 2kb

334 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1355329	protein coding gene	Chr11:70561580-70614483 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018603	protein coding gene	Chr11:71102155-71156576 (+)
A/J	MGP_AJ_G0018571	protein coding gene	Chr11:68405252-68457496 (+)
AKR/J	MGP_AKRJ_G0018540	protein coding gene	Chr11:70465788-70523298 (+)
BALB/cJ	MGP_BALBcJ_G0018543	protein coding gene	Chr11:68725333-68779601 (+)
C3H/HeJ	MGP_C3HHeJ_G0018356	protein coding gene	Chr11:70487160-70542859 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018994	protein coding gene	Chr11:73255004-73313617 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016639	protein coding gene	Chr11:65325006-65378286 (+)
CAST/EiJ	MGP_CASTEiJ_G0017911	protein coding gene	Chr11:70745085-70800833 (+)
CBA/J	MGP_CBAJ_G0018328	protein coding gene	Chr11:76540924-76610142 (+)
DBA/2J	MGP_DBA2J_G0018438	protein coding gene	Chr11:67986856-68041363 (+)
FVB/NJ	MGP_FVBNJ_G0018428	protein coding gene	Chr11:67632453-67684118 (+)
LP/J	MGP_LPJ_G0018508	protein coding gene	Chr11:71677700-71733214 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018451	protein coding gene	Chr11:77113005-77172073 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019036	protein coding gene	Chr11:70718934-70775196 (+)
PWK/PhJ	MGP_PWKPhJ_G0017685	protein coding gene	Chr11:68629269-68683536 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017475	protein coding gene	Chr11:70538041-70592700 (+)
WSB/EiJ	MGP_WSBEiJ_G0017965	protein coding gene	Chr11:70383471-70441148 (+)

Human Ortholog

MINK1, misshapen like kinase 1

Vertebrate Orthologs

8

Human Ortholog

MINK1, misshapen like kinase 1
Orthology source: HomoloGene, HGNC
Synonyms

B55, MAP4K6, MINK, YSK2, ZC3
Links

HGNC:17565

NCBI Gene ID: 50488

neXtProt AC: NX_Q8N4C8

UniProt: Q8N4C8
Chr Location

17p13.2; chr17:4833340-4898061 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 56762
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: MINK1
Gene Tree

Mink1

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

8
Targeted

3
Genomic Mutations

2 involving Mink1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display increased bleeding times and impaired platelet aggregation and dense granule secretion.

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All GO Annotations

35
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
cDNA Data

72

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mink1

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Mink1 interacts with 238 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

96
RefSeq

27
UniProt

10
CCDS

CCDS24954.1, CCDS24955.1, CCDS36205.1, CCDS48837.1
UniGene

42967

Ensembl

ENSMUSG00000020827 (Evidence)
NCBI Gene

50932

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020827	Ensembl Gene Model \| MGI Sequence Detail	51603	C57BL/6J	± kb
transcript	ENSMUST00000072237	Ensembl \| MGI Sequence Detail	4994	Not Applicable
polypeptide	ENSMUSP00000072091	Ensembl \| MGI Sequence Detail	1344	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000010415 misshapen-like kinase 1

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR001180 Citron homology (CNH) domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 72

cDNA 72

Microarray probesets 2

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MGI:1203526

Summaries

All 41

Gene Ontology 7

Phenotypes 18
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:242008 Fu G, et al., Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. J Exp Med. 2017 May 01;214(5):1453-1469

TSS for Mink1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102742	Chr11:70562840-70562897 (+)	-12 bp
Tssr102743	Chr11:70562898-70562922 (+)	29 bp
Tssr102744	Chr11:70562935-70562946 (+)	60 bp
Tssr102745	Chr11:70562980-70563031 (+)	125 bp
Tssr102747	Chr11:70606656-70606670 (+)	43,782 bp
Tssr102748	Chr11:70607101-70607113 (+)	44,226 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/12/2021 MGI 6.16