Mink1 Gene Detail

Summary

• Symbol
  Mink1
• Name
  misshapen-like kinase 1 (zebrafish)
• Synonyms
  Map4k6, MINK, Misshapen/NIKs-related kinase, Ysk2

• Feature Type
  protein coding gene
• IDs
  MGI:1355329
  NCBI Gene: 50932
• Gene Overview
  MyGene.info: MINK1

Location & Maps

• Sequence Map
  Chr11:70562890-70614483 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    51594 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 43.00 cM, cytoband B4
• Mapping Data
  1 experiment

Homology

• Human Ortholog
  MINK1, misshapen like kinase 1

• Vertebrate Orthologs
  8

• Human Ortholog
  MINK1, misshapen like kinase 1
  Orthology source: HomoloGene, HGNC
• Synonyms
  B55, MAP4K6, MINK, YSK2, ZC3
• Links
  HGNC:17565

  NCBI Gene ID: 50488

  neXtProt AC: NX_Q8N4C8

  UniProt: Q8N4C8

  
  
• Chr Location
  17p13.2; chr17:4833340-4898061 (+)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 56762
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: MINK1
• Gene Tree
  Mink1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  14 phenotype references
  

• All Mutations and Alleles
  10
• Chemically induced (other)
  1
• Gene trapped
  8
• Targeted
  1
• Genomic Mutations
  2 involving Mink1
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  44 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  39
• GO References
  7

• External Resources
  FuncBase

Expression

• cDNA Data
  72

• Other Mouse Links
  GEO
  Expression Atlas

Interactions

• Mink1 interacts with 238 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

Sequences &
Gene Models

• All Sequences
  95
• RefSeq
  23
• UniProt
  10
• CCDS
  CCDS24954.1, CCDS24955.1, CCDS36205.1, CCDS48837.1
• UniGene
  42967

• VEGA
  OTTMUSG00000006056 (Evidence)
• Ensembl
  ENSMUSG00000020827 (Evidence)
• NCBI Gene
  50932 (Evidence)

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000006056	VEGA Gene Model | MGI Sequence Detail	51594	C57BL/6J
transcript	OTTMUST00000013651	VEGA | MGI Sequence Detail	4610	Not Applicable
polypeptide	OTTMUSP00000006327	VEGA | MGI Sequence Detail	1337	Not Applicable

Polymorphisms

• SNPs within 2kb
  334 from dbSNP Build 142

Protein
Information

• UniProt
  10 Sequences
• Protein Ontology
  PR:000010415 misshapen-like kinase 1
  (term hierarchy)
• EC
  2.7.11.1
• InterPro Domains
  IPR011989 Armadillo-like helical
  IPR001180 Citron homology (CNH) domain
  IPR017441 Protein kinase, ATP binding site
  IPR000719 Protein kinase domain
  IPR011009 Protein kinase-like domain superfamily
  IPR008271 Serine/threonine-protein kinase, active site
  IPR015943 WD40/YVTN repeat-like-containing domain superfamily

Molecular
Reagents

• All nucleic 72

  cDNA 72

  
  

  Microarray probesets 2

Other
Accession IDs

MGI:1203526

References

• Summaries
  All 39

  Gene Ontology 7

  Phenotypes 14
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:242008 Fu G, et al., Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. J Exp Med. 2017 May 01;214(5):1453-1469