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Mink1 Gene Detail
Summary
  • Symbol
    Mink1
  • Name
    misshapen-like kinase 1 (zebrafish)
  • Synonyms
    Map4k6, MINK, Misshapen/NIKs-related kinase, Ysk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355329
    NCBI Gene: 50932
  • Gene Overview
    MyGene.info: MINK1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70562881-70614483 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 43.00 cM, cytoband B4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    334 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355329
protein coding gene Chr11:70562655-70614483 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018603
protein coding gene Chr11:71102155-71156576 (+)
A/J MGP_AJ_G0018571
protein coding gene Chr11:68405252-68457496 (+)
AKR/J MGP_AKRJ_G0018540
protein coding gene Chr11:70465788-70523298 (+)
BALB/cJ MGP_BALBcJ_G0018543
protein coding gene Chr11:68725333-68779601 (+)
C3H/HeJ MGP_C3HHeJ_G0018356
protein coding gene Chr11:70487160-70542859 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018994
protein coding gene Chr11:73255004-73313617 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016639
protein coding gene Chr11:65325006-65378286 (+)
CAST/EiJ MGP_CASTEiJ_G0017911
protein coding gene Chr11:70745085-70800833 (+)
CBA/J MGP_CBAJ_G0018328
protein coding gene Chr11:76540924-76610142 (+)
DBA/2J MGP_DBA2J_G0018438
protein coding gene Chr11:67986856-68041363 (+)
FVB/NJ MGP_FVBNJ_G0018428
protein coding gene Chr11:67632453-67684118 (+)
LP/J MGP_LPJ_G0018508
protein coding gene Chr11:71677700-71733214 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018451
protein coding gene Chr11:77113005-77172073 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019036
protein coding gene Chr11:70718934-70775196 (+)
PWK/PhJ MGP_PWKPhJ_G0017685
protein coding gene Chr11:68629269-68683536 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017475
protein coding gene Chr11:70538041-70592700 (+)
WSB/EiJ MGP_WSBEiJ_G0017965
protein coding gene Chr11:70383471-70441148 (+)



Homology
more
  • Human Ortholog
    MINK1, misshapen like kinase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MINK1, misshapen like kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    B55, MAP4K6, MINK, YSK2, ZC3
  • Links
    NCBI Gene ID: 50488
    neXtProt AC: NX_Q8N4C8
    UniProt: Q8N4C8

  • Chr Location
    17p13.2; chr17:4833340-4898061 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020827 Ensembl Gene Model | MGI Sequence Detail 51603 C57BL/6J ±  kb
transcript ENSMUST00000072237 Ensembl | MGI Sequence Detail 4994 Not Applicable  
polypeptide ENSMUSP00000072091 Ensembl | MGI Sequence Detail 1344 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 72
    cDNA 72

    Microarray probesets 2
Other
Accession IDs
less
MGI:1203526
References
more
  • Summaries
    All 40
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:242008 Fu G, et al., Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. J Exp Med. 2017 May 01;214(5):1453-1469

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/27/2018
MGI 6.13
The Jackson Laboratory