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Mink1 Gene Detail
Summary
  • Symbol
    Mink1
  • Name
    misshapen-like kinase 1 (zebrafish)
  • Synonyms
    Map4k6, MINK, Misshapen/NIKs-related kinase, Ysk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355329
    NCBI Gene: 50932
  • Gene Overview
    MyGene.info: MINK1
Location & Maps
more
  • Sequence Map
    Chr11:70562890-70614483 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51594 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 43.00 cM, cytoband B4
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MINK1, misshapen like kinase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MINK1, misshapen like kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B55, MAP4K6, MINK, YSK2, ZC3
  • Links
    NCBI Gene ID: 50488
    neXtProt AC: NX_Q8N4C8

  • Chr Location
    17p13.2; chr17:4833340-4898061 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Targeted
    1
  • Genomic Mutations
    2 involving Mink1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006056 VEGA Gene Model | MGI Sequence Detail 51594 C57BL/6J ±  kb
transcript OTTMUST00000013651 VEGA | MGI Sequence Detail 4610 Not Applicable  
polypeptide OTTMUSP00000006327 VEGA | MGI Sequence Detail 1337 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    334 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 72
    cDNA 72

    Microarray probesets 2
Other
Accession IDs
less
MGI:1203526
References
more
  • Summaries
    All 30
    Gene Ontology 7
    Phenotypes 14
  • Earliest
    J:40334 Osada S, et al., YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways. Oncogene. 1997 May 1;14(17):2047-57
  • Latest
    J:231551 Yue M, et al., Misshapen/NIK-related kinase (MINK1) is involved in platelet function, hemostasis, and thrombus formation. Blood. 2016 Feb 18;127(7):927-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory