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Nasp Gene Detail
Summary
  • Symbol
    Nasp
  • Name
    nuclear autoantigenic sperm protein (histone-binding)
  • Synonyms
    5033430J04Rik, D4Ertd767e, Epcs32, Nasp-T
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355328
    NCBI Gene: 50927
  • Gene Overview
    MyGene.info: NASP
Location & Maps
more
  • Sequence Map
    Chr4:116601052-116627941 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26890 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 53.24 cM, cytoband D1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    NASP, nuclear autoantigenic sperm protein
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NASP, nuclear autoantigenic sperm protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FLB7527, HMDRA1, PRO1999
  • Links
    NCBI Gene ID: 4678
    neXtProt AC: NX_P49321

  • Chr Location
    1p34.1; chr1:45583988-45618906 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    97
  • Chemically induced (other)
    2
  • Gene trapped
    91
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Nasp
  • Incidental Mutations
Mice homozygous for a null mutation display embryonic lethality before implantation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009439 VEGA Gene Model | MGI Sequence Detail 26890 C57BL/6J ±  kb
transcript OTTMUST00000021500 VEGA | MGI Sequence Detail 2520 Not Applicable  
polypeptide OTTMUSP00000009823 VEGA | MGI Sequence Detail 773 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    110 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010993 nuclear autoantigenic sperm protein
  • InterPro Domains
    IPR011990 Tetratricopeptide-like helical domain
    IPR019734 Tetratricopeptide repeat
    IPR013026 Tetratricopeptide repeat-containing domain
    IPR019544 Tetratricopeptide, SHNi-TPR domain
Molecular
Reagents
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  • All nucleic 18
    Genomic 1
    cDNA 16
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1289187, MGI:1914654, MGI:2140195, MGI:2145613
References
more
  • Summaries
    All 49
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:54434 Leimeister C, et al., Screen for genes regulated during early kidney morphogenesis. Dev Genet. 1999;24(3-4):273-83
  • Latest
    J:228946 Wei N, et al., SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing. Cell Rep. 2015 Nov 24;13(8):1647-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory