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Preb
Gene Detail
 Symbol
Name
ID
Preb
prolactin regulatory element binding
MGI:1355326
Feature Type protein coding gene
Genetic Map
Chromosome 5
16.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:30950853-30960330 bp, - strand
From VEGA annotation of GRCm38

  9478 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40877  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Preb

Human
homologs
Human Homolog PREB, prolactin regulatory element binding
NCBI Gene ID 10113
neXtProt AC  NX_Q9HCU5
Human Synonyms  SEC12
Human Chr (Location)  2p23.3; chr2:27130756-27134674 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Radiation induced(2) Targeted(2)
Genomic Mutations involving Preb (2)
Incidental mutations (data from APF )
Alleles Annotated to Human Diseases(1)   
Interactions
Preb interacts with 373 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process positive regulation of transcription from RNA polymerase II promoter, protein transport, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (185)    Tissues (152)    Images (25)
Theiler Stages: 17, 21, 22, 23, 27, 28
Assay TypeResults
RNA in situ 185
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022374 (Evidence)
Ensembl Gene ModelENSMUSG00000045302 (Evidence)
Entrez Gene50907 (Evidence)
Consensus CDS ProjectCCDS39051.1
International Mouse Knockout Project StatusPreb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022374 VEGA Gene Model | MGI Sequence Detail 9478 C57BL/6J ±  kb
transcript OTTMUST00000053415 VEGA | MGI Sequence Detail 6269 Not Applicable 
polypeptide OTTMUSP00000025398 VEGA | MGI Sequence Detail 417 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(9) UniProt(5)
Polymorphisms PCR(1) : SNPs within 2kb(89 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily
InterPro IPR001680 WD40 repeat
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000013197 prolactin regulatory element-binding protein
References (Earliest) J:60870 Taylor Clelland CL, et al., Mapping and developmental expression analysis of the WD-repeat gene preb. Genomics. 2000 Feb 1;63(3):391-9
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)
Other
accession IDs
MGI:2141329

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory