|Human Homolog||TNFSF14, tumor necrosis factor (ligand) superfamily, member 14|
|NCBI Gene ID||8740|
|Human Synonyms||CD258, HVEML, LIGHT, LTg, TR2|
|Human Chr (Location)||19p13.3; chr19:6661253-6670588 (-) GRCh38|
Targeted disruption of this gene leads to selective impairment of CD8+ T cell function. Mice homozygous for a knock-out allele exhibit defects in CD8+ T cell-mediated allogenic responses. Mice homozygous for a different knock-out allele show increased resistance to experimentally-induced hepatitis.
|Process||immune response, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, ...|
|Component||extracellular region, extracellular space, ...|
|Function||cysteine-type endopeptidase inhibitor activity involved in apoptotic process, cytokine activity, ...|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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