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Tnfsf14
Gene Detail
Symbol

Name
ID
Tnfsf14
tumor necrosis factor (ligand) superfamily, member 14
MGI:1355317
Synonyms
HVEM-L, LIGHT
Feature Type
protein coding gene
Genetic Map
Chromosome 17
29.71 cM, cytoband D-E1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:57189492-57194189 bp, - strand
From Ensembl annotation of GRCm38

  4698 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2822  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: TNFSF14
Protein SuperFamily: tumor necrosis factor, TNF alpha type
Gene Tree: Tnfsf14

Human
homologs
TNFSF14, tumor necrosis factor (ligand) superfamily, member 14
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8740
neXtProt AC: NX_O43557

Human Synonyms: CD258, HVEML, LIGHT, LTg, TR2

Human Chr (Location): 19p13.3; chr19:6658135-6670588 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted disruption of this gene leads to selective impairment of CD8+ T cell function. Mice homozygous for a knock-out allele exhibit defects in CD8+ T cell-mediated allogenic responses. Mice homozygous for a different knock-out allele show increased resistance to experimentally-induced hepatitis.
 
Interactions
Tnfsf14 interacts with 115 markers (Mir1b, Mir19b-1, Mir19b-2, ...)
Expression
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000005824 (Evidence)
Entrez Gene 50930 (Evidence)
UniGene 483369
DFCI TC1590303
DoTS DT.87026128
NIA Mouse Gene Index U037973
Consensus CDS Project CCDS28928.1
International Mouse Phenotyping Consortium Status Tnfsf14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005824 Ensembl Gene Model | MGI Sequence Detail 4698 C57BL/6J ±  kb
transcript ENSMUST00000005976 Ensembl | MGI Sequence Detail 1859 Not Applicable 
polypeptide ENSMUSP00000005976 Ensembl | MGI Sequence Detail 239 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006052 Tumour necrosis factor
InterPro IPR006053 Tumour necrosis factor alpha/beta/c
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000002222 tumor necrosis factor ligand superfamily member 14
References
(Earliest) J:60454 Matsumoto M, Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting. J Med Invest. 1999 Aug;46(3-4):141-50
(Latest) J:219573 Van Praet JT, et al., Commensal microbiota influence systemic autoimmune responses. EMBO J. 2015 Feb 12;34(4):466-74
All references(74)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory