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Tnfsf14
Gene Detail
 Symbol
Name
ID
Tnfsf14
tumor necrosis factor (ligand) superfamily, member 14
MGI:1355317
Synonyms HVEM-L, LIGHT
Feature Type protein coding gene
Genetic Map
Chromosome 17
29.71 cM, cytoband D-E1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:57189492-57194189 bp, - strand
From NCBI annotation of GRCm38

  4698 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2822  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: tumor necrosis factor, TNF alpha type
Gene Tree: Tnfsf14

Human
homologs
Human Homolog TNFSF14, tumor necrosis factor (ligand) superfamily, member 14
NCBI Gene ID 8740
neXtProt AC  NX_O43557
Human Synonyms  CD258, HVEML, LIGHT, LTg, TR2
Human Chr (Location)  19p13.3; chr19:6661253-6670588 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted disruption of this gene leads to selective impairment of CD8+ T cell function. Mice homozygous for a knock-out allele exhibit defects in CD8+ T cell-mediated allogenic responses. Mice homozygous for a different knock-out allele show increased resistance to experimentally-induced hepatitis.
 
Interactions
Tnfsf14 interacts with 115 markers (Mir1b, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process immune response, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, ...
Component extracellular region, extracellular space, ...
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process, cytokine activity, ...
External Resources: FuncBase
Expression
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000005824 (Evidence)
Entrez Gene50930 (Evidence)
UniGene483369
DFCITC1590303
DoTSDT.87026128
NIA Mouse Gene IndexU037973
Consensus CDS ProjectCCDS28928.1
International Mouse Knockout Project StatusTnfsf14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 50930 NCBI Gene Model | MGI Sequence Detail 4698 C57BL/6J ±  kb
transcript NM_019418 RefSeq | MGI Sequence Detail 1869 C57BL/6 
polypeptide Q9QYH9 UniProt | EBI | MGI Sequence Detail 239 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006052 Tumour necrosis factor
InterPro IPR006053 Tumour necrosis factor alpha/beta/c
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000002222 tumor necrosis factor ligand superfamily member 14
Graphical View of Protein Domain Structure
References (Earliest) J:60454 Matsumoto M, Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting. J Med Invest. 1999 Aug;46(3-4):141-50
(Latest) J:205369 Mana P, et al., LIGHT (TNFSF14/CD258) is a decisive factor for recovery from experimental autoimmune encephalomyelitis. J Immunol. 2013 Jul 1;191(1):154-63
All references(72)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory