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Tnfsf14 Gene Detail
Summary
  • Symbol
    Tnfsf14
  • Name
    tumor necrosis factor (ligand) superfamily, member 14
  • Synonyms
    HVEM-L, LIGHT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355317
    NCBI Gene: 50930
  • Gene Overview
    MyGene.info: TNFSF14
Location & Maps
more
  • Sequence Map
    Chr17:57189492-57194189 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4698 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.71 cM, cytoband D-E1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TNFSF14, tumor necrosis factor superfamily member 14
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TNFSF14, tumor necrosis factor superfamily member 14
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD258, HVEML, LIGHT, LTg
  • Links
    NCBI Gene ID: 8740
    neXtProt AC: NX_O43557

  • Chr Location
    19p13.3; chr19:6658135-6670588 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 5 alleles in 7 genetic backgrounds
    21 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Targeted
    7
  • Transgenic
    1
  • Incidental Mutations
Targeted disruption of this gene leads to selective impairment of CD8+ T cell function. Mice homozygous for a knock-out allele exhibit defects in CD8+ T cell-mediated allogenic responses. Mice homozygous for a different knock-out allele show increased resistance to experimentally-induced hepatitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005824 Ensembl Gene Model | MGI Sequence Detail 4698 C57BL/6J ±  kb
transcript ENSMUST00000005976 Ensembl | MGI Sequence Detail 1859 Not Applicable  
polypeptide ENSMUSP00000005976 Ensembl | MGI Sequence Detail 239 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    57 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000002222 tumor necrosis factor ligand superfamily member 14
  • InterPro Domains
    IPR006053 Tumour necrosis factor
    IPR006052 Tumour necrosis factor domain
    IPR008983 Tumour necrosis factor-like domain
Molecular
Reagents
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  • All nucleic 5
    cDNA 5

    Microarray probesets 3
References
more
  • Summaries
    All 75
    Gene Ontology 7
    Phenotypes 47
  • Earliest
    J:60454 Matsumoto M, Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting. J Med Invest. 1999 Aug;46(3-4):141-50
  • Latest
    J:229773 Kumar V, et al., A dendritic-cell-stromal axis maintains immune responses in lymph nodes. Immunity. 2015 Apr 21;42(4):719-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory