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Tnfsf14 Gene Detail
Summary
  • Symbol
    Tnfsf14
  • Name
    tumor necrosis factor (ligand) superfamily, member 14
  • Synonyms
    HVEM-L, LIGHT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355317
    NCBI Gene: 50930
  • Gene Overview
    MyGene.info: TNFSF14
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:57189492-57194189 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.71 cM, cytoband D-E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355317
protein coding gene Chr17:57189474-57194189 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023958
protein coding gene Chr17:58954907-58959604 (-)
A/J MGP_AJ_G0023916
protein coding gene Chr17:57317800-57322498 (-)
AKR/J MGP_AKRJ_G0023885
protein coding gene Chr17:58048199-58052896 (-)
BALB/cJ MGP_BALBcJ_G0023917
protein coding gene Chr17:57158861-57163558 (-)
C3H/HeJ MGP_C3HHeJ_G0023681
protein coding gene Chr17:58765454-58770151 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024363
protein coding gene Chr17:61248428-61253125 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021809
protein coding gene Chr17:53788725-53793558 (-)
CAST/EiJ MGP_CASTEiJ_G0023163
protein coding gene Chr17:59075565-59080276 (-)
CBA/J MGP_CBAJ_G0023657
protein coding gene Chr17:63645024-63649721 (-)
DBA/2J MGP_DBA2J_G0023785
protein coding gene Chr17:56010743-56015440 (-)
FVB/NJ MGP_FVBNJ_G0023751
protein coding gene Chr17:55589725-55594422 (-)
LP/J MGP_LPJ_G0023867
protein coding gene Chr17:59640327-59645024 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023779
protein coding gene Chr17:63075542-63080239 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024407
protein coding gene Chr17:58407897-58412594 (-)
PWK/PhJ MGP_PWKPhJ_G0022909
protein coding gene Chr17:55382848-55387536 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022720
protein coding gene Chr17:55181199-55185910 (-)
WSB/EiJ MGP_WSBEiJ_G0023229
protein coding gene Chr17:59044556-59049268 (-)



Homology
more
  • Human Ortholog
    TNFSF14, TNF superfamily member 14
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TNFSF14, TNF superfamily member 14
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD258, HVEML, LIGHT, LTg
  • Links
    NCBI Gene ID: 8740
    neXtProt AC: NX_O43557
    UniProt: O43557

  • Chr Location
    19p13.3; chr19:6658126-6670595 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 5 alleles in 7 genetic backgrounds
    21 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted disruption of this gene leads to selective impairment of CD8+ T cell function. Mice homozygous for a knock-out allele exhibit defects in CD8+ T cell-mediated allogenic responses. Mice homozygous for a different knock-out allele show increased resistance to experimentally-induced hepatitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005824 Ensembl Gene Model | MGI Sequence Detail 4698 C57BL/6J ±  kb
transcript ENSMUST00000005976 Ensembl | MGI Sequence Detail 1847 Not Applicable  
polypeptide ENSMUSP00000005976 Ensembl | MGI Sequence Detail 239 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 3
References
more
  • Summaries
    All 84
    Gene Ontology 7
    Phenotypes 48
  • Earliest
    J:60454 Matsumoto M, Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting. J Med Invest. 1999 Aug;46(3-4):141-50
  • Latest
    J:240745 Hardbower DM, et al., Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E751-E760

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory