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Tmod3 Gene Detail
Summary
  • Symbol
    Tmod3
  • Name
    tropomodulin 3
  • Synonyms
    ubiquitous tropomodulin, U-Tmod, UTMOD
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355315
    NCBI Gene: 50875
  • Gene Overview
    MyGene.info: TMOD3
Location & Maps
more
  • Sequence Map
    Chr9:75497796-75559657 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      61862 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 42.30 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TMOD3, tropomodulin 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TMOD3, tropomodulin 3
    Orthology source: HomoloGene
  • Synonyms
    UTMOD
  • Links
    NCBI Gene ID: 29766
    neXtProt AC: NX_Q9NYL9

  • Chr Location
    15q21.2; chr15:51829628-51912138 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    1
  • Gene trapped
    19
  • Targeted
    1
  • Genomic Mutations
    1 involving Tmod3
Mice homozygous for a gene trap allele exhibit lethality during fetal development with anemia due to impaired erythroid terminal differentiation in the fetal liver.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058587 Ensembl Gene Model | MGI Sequence Detail 61862 C57BL/6J ±  kb
transcript ENSMUST00000072232 Ensembl | MGI Sequence Detail 3578 Not Applicable  
polypeptide ENSMUSP00000072087 Ensembl | MGI Sequence Detail 352 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    325 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 176
    cDNA 174
    Primer pair 2

    Microarray probesets 6
References
more
  • Summaries
    All 39
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:60558 Cox PR, et al., Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs. Genomics. 2000 Jan 1;63(1):97-107
  • Latest
    J:224614 Sui Z, et al., Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis. Blood. 2015 Jul 23;126(4):520-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory