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Tmod3 Gene Detail
Summary
  • Symbol
    Tmod3
  • Name
    tropomodulin 3
  • Synonyms
    ubiquitous tropomodulin, U-Tmod, UTMOD
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355315
    NCBI Gene: 50875
  • Gene Overview
    MyGene.info: TMOD3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:75497784-75559687 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 42.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    325 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355315
protein coding gene Chr9:75497707-75559687 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035041
protein coding gene Chr9:75815889-75884592 (-)
A/J MGP_AJ_G0035022
protein coding gene Chr9:73169648-73231558 (-)
AKR/J MGP_AKRJ_G0034951
protein coding gene Chr9:74914665-74979866 (-)
BALB/cJ MGP_BALBcJ_G0035014
protein coding gene Chr9:72838020-72899514 (-)
C3H/HeJ MGP_C3HHeJ_G0034723
protein coding gene Chr9:75384692-75448013 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035532
protein coding gene Chr9:77837716-77900271 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032443
protein coding gene Chr9:72526672-72584992 (-)
CAST/EiJ MGP_CASTEiJ_G0034045
protein coding gene Chr9:75730121-75795271 (-)
CBA/J MGP_CBAJ_G0034695
protein coding gene Chr9:80501830-80567135 (-)
DBA/2J MGP_DBA2J_G0034855
protein coding gene Chr9:72837701-72898713 (-)
FVB/NJ MGP_FVBNJ_G0034797
protein coding gene Chr9:72137330-72197659 (-)
LP/J MGP_LPJ_G0034936
protein coding gene Chr9:76064376-76131961 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034838
protein coding gene Chr9:81578321-81645651 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035555
protein coding gene Chr9:75077035-75141477 (-)
PWK/PhJ MGP_PWKPhJ_G0033749
protein coding gene Chr9:73127163-73187730 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033582
protein coding gene Chr9:75314756-75378996 (-)
WSB/EiJ MGP_WSBEiJ_G0034157
protein coding gene Chr9:74990958-75056527 (-)



Homology
more
  • Human Ortholog
    TMOD3, tropomodulin 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TMOD3, tropomodulin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    UTMOD
  • Links
    NCBI Gene ID: 29766
    neXtProt AC: NX_Q9NYL9
    UniProt: Q9NYL9

  • Chr Location
    15q21.2; chr15:51829628-51912138 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit lethality during fetal development with anemia due to impaired erythroid terminal differentiation in the fetal liver.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50875 NCBI Gene Model | MGI Sequence Detail 61904 C57BL/6J ±  kb
    transcript NM_001357828 RefSeq | MGI Sequence Detail 3926 C57BL/6  
    polypeptide Q9JHJ0 UniProt | EBI | MGI Sequence Detail 352 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 179
      cDNA 176
      Primer pair 2
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:60558 Cox PR, et al., Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs. Genomics. 2000 Jan 1;63(1):97-107
    • Latest
      J:224614 Sui Z, et al., Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis. Blood. 2015 Jul 23;126(4):520-30

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory