C1ra
Gene Detail

Symbol Name ID

C1ra complement component 1, r subcomponent A MGI:1355313

Synonyms

mC1rA

Feature Type

protein coding gene

Genetic Map

Chromosome 6

59.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:124512632-124523440 bp, + strand From Ensembl annotation of GRCm38   10809 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1313  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken

Protein SuperFamily: C1r-like complement-activating serine protease
Gene Tree: C1ra

Human homologs

Human Homolog		C1R, complement component 1, r subcomponent
NCBI Gene ID		715
neXtProt AC		NX_P00736
Human Chr (Location)		12p13
Disease Associations		(1) Diseases Associated with Human C1R

Alleles and phenotypes

All alleles(1) : Targeted(1)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	complement activation, complement activation, classical pathway, ...
Component	extracellular region
Function	calcium ion binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(80)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(81) cDNA(80) Primer pair(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000055172 (Evidence)
Entrez Gene	50909 (Evidence)
UniGene	333375
EC	3.4.21.41
Consensus CDS Project	CCDS20521.1
International Mouse Knockout Project Status	C1ra

Sequences

Length	Strain/Species
genomic	ENSMUSG00000055172	Ensembl Gene Model | MGI Sequence Detail	10809	C57BL/6J
transcript	ENSMUST00000068593	Ensembl | MGI Sequence Detail	2751	Not Applicable
polypeptide	ENSMUSP00000063707	Ensembl | MGI Sequence Detail	707	Not Applicable

All sequences(29) RefSeq(2) UniProt(4)

Polymorphisms

PCR(1) : SNPs(46 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000859	CUB domain
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR001254	Peptidase S1
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR024175	Peptidase S1A, complement C1r/C1S/mannan-binding
InterPro	IPR018114	Peptidase S1, trypsin family, active site
InterPro	IPR000436	Sushi/SCR/CCP
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000004895	complement C1r-A subcomponent

References

(Earliest) J:61131 Lawson PR, et al., A novel PCR-based technique using expressed sequence tags and gene homology for murine genetic mapping: localization of the complement genes. Int Immunol. 2000 Mar;12(3):231-40
(Latest) J:174459 Boyle MP, et al., Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. J Comp Neurol. 2011 Aug 1;519(11):2061-89
All references(27)

Other accession IDs

MGI:2141380, MGI:3719032