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C1ra
Gene Detail
Symbol

Name
ID
C1ra
complement component 1, r subcomponent A
MGI:1355313
Synonyms
mC1rA
Feature Type
protein coding gene
Genetic Map
Chromosome 6
59.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:124512632-124523440 bp, + strand
From Ensembl annotation of GRCm38

  10809 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1313  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 2 western clawed frog

Protein SuperFamily: C1r-like complement-activating serine protease
Gene Tree: C1ra

Human
homologs
Human Homolog C1R, complement component 1, r subcomponent
NCBI Gene ID 715
neXtProt AC  NX_P00736
Human Chr (Location)  12p13
Disease Associations  (1) Diseases Associated with Human C1R
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
C1ra interacts with 97 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process complement activation, complement activation, classical pathway, ...
Component blood microparticle, extracellular region, ...
Function calcium ion binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000055172 (Evidence)
Entrez Gene50909 (Evidence)
EC3.4.21.41
Consensus CDS ProjectCCDS20521.1
International Mouse Knockout Project StatusC1ra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055172 Ensembl Gene Model | MGI Sequence Detail 10809 C57BL/6J ±  kb
transcript ENSMUST00000068593 Ensembl | MGI Sequence Detail 2751 Not Applicable 
polypeptide ENSMUSP00000063707 Ensembl | MGI Sequence Detail 707 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(87 from dbSNP Build 137)    SNPs within 2kb including multiple locations(133)
Protein-related
information
ResourceIDDescription
InterPro IPR000859 CUB domain
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR024175 Peptidase S1A, complement C1r/C1S/mannan-binding
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR000436 Sushi/SCR/CCP
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000004895 complement C1r-A subcomponent
References
(Earliest) J:61131 Lawson PR, et al., A novel PCR-based technique using expressed sequence tags and gene homology for murine genetic mapping: localization of the complement genes. Int Immunol. 2000 Mar;12(3):231-40
(Latest) J:174459 Boyle MP, et al., Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. J Comp Neurol. 2011 Aug 1;519(11):2061-89
All references(26)
Other
accession IDs
MGI:2141380, MGI:3719032

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory