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C1s1
Gene Detail
Symbol

Name
ID
C1s1
complement component 1, s subcomponent 1
MGI:1355312
Synonyms
C1s
Feature Type
protein coding gene
Genetic Map
Chromosome 6
59.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:124530345-124542359 bp, - strand
From VEGA annotation of GRCm38

  12015 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1314  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: C1r-like complement-activating serine protease
Gene Tree: C1s1

Human
homologs
Human Homolog C1S, complement component 1, s subcomponent
NCBI Gene ID 716
neXtProt AC  NX_P09871
Human Chr (Location)  12p13; chr12:7060676-7071032 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human C1S
Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
C1s1 interacts with 90 markers (Mir24-1, Mir24-2, Mir31, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process complement activation, complement activation, classical pathway, ...
Component blood microparticle, extracellular region, ...
Function calcium ion binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (72)    Tissues (4)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 70
RT-PCR 2
cDNA source data(79)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(81) cDNA(79) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034941 (Evidence)
Ensembl Gene ModelENSMUSG00000038521 (Evidence)
Entrez Gene50908 (Evidence)
UniGene219527
DFCITC1577081, TC1604695, TC1682960
DoTSDT.101390300, DT.534492, DT.97367447
NIA Mouse Gene IndexU040210
EC3.4.21.42
Consensus CDS ProjectCCDS51907.1
International Mouse Knockout Project StatusC1s1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034941 VEGA Gene Model | MGI Sequence Detail 12015 C57BL/6J ±  kb
transcript OTTMUST00000088837 VEGA | MGI Sequence Detail 2946 Not Applicable 
polypeptide OTTMUSP00000048474 VEGA | MGI Sequence Detail 694 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(8) UniProt(6)
Polymorphisms
PCR(1) : SNPs within 2kb(310 from dbSNP Build 137)    SNPs within 2kb including multiple locations(488)
Protein-related
information
ResourceIDDescription
InterPro IPR000859 CUB domain
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR024175 Peptidase S1A, complement C1r/C1S/mannan-binding
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR000436 Sushi/SCR/CCP
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000004897 complement C1s-A subcomponent
References
(Earliest) J:61131 Lawson PR, et al., A novel PCR-based technique using expressed sequence tags and gene homology for murine genetic mapping: localization of the complement genes. Int Immunol. 2000 Mar;12(3):231-40
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(31)
Other
accession IDs
MGI:1353567, MGI:2141372, MGI:2141399

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory