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C1s1
Gene Detail
Symbol

Name
ID
C1s1
complement component 1, s subcomponent 1
MGI:1355312
Synonyms
C1s
Feature Type
protein coding gene
Genetic Map
Chromosome 6
59.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:124530345-124542359 bp, - strand
From VEGA annotation of GRCm38

  12015 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1314  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: C1S
Protein SuperFamily: C1r-like complement-activating serine protease
Gene Tree: C1s1

Human
homologs
C1S, complement component 1, s subcomponent
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 716
neXtProt AC: NX_P09871

Human Chr (Location): 12p13; chr12:7060676-7071032 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human C1S

Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
C1s1 interacts with 89 markers (Mir24-1, Mir24-2, Mir31, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process complement activation, complement activation, classical pathway, ...
Component blood microparticle, extracellular exosome, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (72)    Tissues (4)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 70
RT-PCR 2
cDNA source data(79)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase c1s    NEW 
Molecular
reagents
All nucleic(81) cDNA(79) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000034941 (Evidence)
Ensembl Gene Model ENSMUSG00000038521 (Evidence)
Entrez Gene 50908 (Evidence)
UniGene 219527
DFCI TC1577081, TC1604695, TC1682960
DoTS DT.101390300, DT.534492, DT.97367447
NIA Mouse Gene Index U040210
EC 3.4.21.42
Consensus CDS Project CCDS51907.1
International Mouse Phenotyping Consortium Status C1s1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034941 VEGA Gene Model | MGI Sequence Detail 12015 C57BL/6J ±  kb
transcript OTTMUST00000088914 VEGA | MGI Sequence Detail 2906 Not Applicable 
polypeptide OTTMUSP00000048526 VEGA | MGI Sequence Detail 694 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(12) UniProt(6)
Polymorphisms
PCR(1) : SNPs within 2kb(310 from dbSNP Build 137)    SNPs within 2kb including multiple locations(488)
Protein-related
information
ResourceIDDescription
InterPro IPR000859 CUB domain
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR001881 EGF-like calcium-binding domain
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR024175 Peptidase S1A, complement C1r/C1S/mannan-binding
InterPro IPR009003 Peptidase S1, PA clan
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001254 Serine proteases, trypsin domain
InterPro IPR000436 Sushi/SCR/CCP domain
Protein Ontology PR:000004897 complement C1s-A subcomponent
References
(Earliest) J:61131 Lawson PR, et al., A novel PCR-based technique using expressed sequence tags and gene homology for murine genetic mapping: localization of the complement genes. Int Immunol. 2000 Mar;12(3):231-40
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(31)
Other
accession IDs
MGI:1353567, MGI:2141372, MGI:2141399

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory