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Neu3
Gene Detail
Symbol

Name
ID
Neu3
neuraminidase 3
MGI:1355305
Synonyms
ganglioside sialidase, membrane sialidase
Feature Type
protein coding gene
Genetic Map
Chromosome 7
54.15 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:99811439-99828417 bp, - strand
From Ensembl annotation of GRCm38

  16979 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4847  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 5 zebrafish

HCOP human homology predictions: NEU3
Gene Tree: Neu3

Human
homologs
NEU3, sialidase 3 (membrane sialidase)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10825
neXtProt AC: NX_Q9UQ49

Human Synonyms: SIAL3

Human Chr (Location): 11q13.5; chr11:74988905-75007698 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased colon carcinogenesis induced by azoxymethane and dextran sodium sulfate.
 
Phenotype Images(1)
Interactions
Neu3 interacts with 212 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process carbohydrate metabolic process, ganglioside catabolic process, ...
Component membrane, plasma membrane
Function alpha-sialidase activity, exo-alpha-(2->3)-sialidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (7)    Tissues (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 7
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase neu3 ; ZFIN neu3.1, neu3.2, neu3.3, neu3.5    NEW 
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000035239 (Evidence)
Entrez Gene 50877 (Evidence)
UniGene 103703
DFCI TC1586763
DoTS DT.55122594
NIA Mouse Gene Index U028897
EC 3.2.1.18
Consensus CDS Project CCDS21489.1
International Mouse Phenotyping Consortium Status Neu3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035239 Ensembl Gene Model | MGI Sequence Detail 16979 C57BL/6J ±  kb
transcript ENSMUST00000036331 Ensembl | MGI Sequence Detail 3341 Not Applicable 
polypeptide ENSMUSP00000045222 Ensembl | MGI Sequence Detail 418 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(10) UniProt(2)
Polymorphisms
SNPs within 2kb(186 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026944 Sialidase-3
InterPro IPR026856 Sialidase family
InterPro IPR011040 Sialidases
Protein Ontology PR:000011147 sialidase-3
References
(Earliest) J:61065 Hasegawa T, et al., Molecular cloning of mouse ganglioside sialidase and its increased expression in Neuro2a cell differentiation [published erratum appears in J Biol Chem 2000 May 12;275(19):14778]. J Biol Chem. 2000 Mar 17;275(11):8007-15
(Latest) J:189604 Yamaguchi K, et al., Reduced susceptibility to colitis-associated colon carcinogenesis in mice lacking plasma membrane-associated sialidase. PLoS One. 2012;7(7):e41132
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory