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Neu3
Gene Detail
 Symbol
Name
ID
Neu3
neuraminidase 3
MGI:1355305
Synonyms ganglioside sialidase, membrane sialidase
Feature Type protein coding gene
Genetic Map
Chromosome 7
54.15 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:99811439-99828417 bp, - strand
From NCBI annotation of GRCm38

  16979 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4847  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 5 zebrafish

Gene Tree: Neu3

Human
homologs
Human Homolog NEU3, sialidase 3 (membrane sialidase)
NCBI Gene ID 10825
neXtProt AC  NX_Q9UQ49
Human Synonyms  SIAL3
Human Chr (Location)  11q13.5; chr11:74988905-75007698 (+)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased colon carcinogenesis induced by azoxymethane and dextran sodium sulfate.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process carbohydrate metabolic process, ganglioside catabolic process, ...
Component membrane, plasma membrane
Function alpha-sialidase activity, exo-alpha-(2->3)-sialidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (7)    Tissues (5)   
Theiler Stages: 20, 22, 24, 26, 28
Assay TypeResults
RT-PCR 7
cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000035239 (Evidence)
Entrez Gene50877 (Evidence)
UniGene103703
DFCITC1586763
DoTSDT.55122594
NIA Mouse Gene IndexU028897
EC3.2.1.18
Consensus CDS ProjectCCDS21489.1
International Mouse Knockout Project StatusNeu3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 50877 NCBI Gene Model | MGI Sequence Detail 16979 C57BL/6J ±  kb
transcript NM_016720 RefSeq | MGI Sequence Detail 3341 C57BL/6 
polypeptide Q9JMH7 UniProt | EBI | MGI Sequence Detail 418 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(186 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026944 Sialidase-3
InterPro IPR026856 Sialidase family
InterPro IPR011040 Sialidases
Protein Ontology PR:000011147 sialidase-3
Graphical View of Protein Domain Structure
References (Earliest) J:61065 Hasegawa T, et al., Molecular cloning of mouse ganglioside sialidase and its increased expression in Neuro2a cell differentiation [published erratum appears in J Biol Chem 2000 May 12;275(19):14778]. J Biol Chem. 2000 Mar 17;275(11):8007-15
(Latest) J:189604 Yamaguchi K, et al., Reduced susceptibility to colitis-associated colon carcinogenesis in mice lacking plasma membrane-associated sialidase. PLoS One. 2012;7(7):e41132
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory