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Neu3 Gene Detail
Summary
  • Symbol
    Neu3
  • Name
    neuraminidase 3
  • Synonyms
    ganglioside sialidase, membrane sialidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355305
    NCBI Gene: 50877
  • Gene Overview
    MyGene.info: NEU3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:99811439-99828417 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.15 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    183 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355305
protein coding gene Chr7:99811439-99828417 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032557
protein coding gene Chr7:102644514-102662939 (-)
A/J MGP_AJ_G0032531
protein coding gene Chr7:100076637-100096579 (-)
AKR/J MGP_AKRJ_G0032467
protein coding gene Chr7:102463944-102488506 (-)
BALB/cJ MGP_BALBcJ_G0032542
protein coding gene Chr7:99755510-99773019 (-)
C3H/HeJ MGP_C3HHeJ_G0032257
protein coding gene Chr7:102825791-102844234 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033040
protein coding gene Chr7:106555758-106581251 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0031584
protein coding gene Chr7:94351209-94368203 (-)
CBA/J MGP_CBAJ_G0032224
protein coding gene Chr7:110239458-110254274 (-)
DBA/2J MGP_DBA2J_G0032375
protein coding gene Chr7:98410310-98428371 (-)
FVB/NJ MGP_FVBNJ_G0032332
protein coding gene Chr7:98203272-98225334 (-)
LP/J MGP_LPJ_G0032465
protein coding gene Chr7:103997889-104020892 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032365
protein coding gene Chr7:111656745-111678410 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033062
protein coding gene Chr7:101729072-101746843 (-)
PWK/PhJ MGP_PWKPhJ_G0031302
protein coding gene Chr7:91508526-91525093 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031145
protein coding gene Chr7:89034968-89053324 (-)
WSB/EiJ MGP_WSBEiJ_G0031701
protein coding gene Chr7:102413087-102428788 (-)



Homology
more
  • Human Ortholog
    NEU3, neuraminidase 3
  • Vertebrate Orthologs
    14
  • Human Ortholog
    NEU3, neuraminidase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SIAL3
  • Links
    NCBI Gene ID: 10825
    neXtProt AC: NX_Q9UQ49
    UniProt: Q9UQ49

  • Chr Location
    11q13.4; chr11:74988905-75007698 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4847
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;5 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NEU3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased colon carcinogenesis induced by azoxymethane and dextran sodium sulfate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 50877 NCBI Gene Model | MGI Sequence Detail 16979 C57BL/6J ±  kb
transcript NM_016720 RefSeq | MGI Sequence Detail 3341 C57BL/6  
polypeptide Q9JMH7 UniProt | EBI | MGI Sequence Detail 418 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 44
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:262126 Seyrantepe V, et al., Murine Sialidase Neu3 facilitates GM2 degradation and bypass in mouse model of Tay-Sachs disease. Exp Neurol. 2018 Jan;299(Pt A):26-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory