Neu3
Gene Detail

Symbol Name ID

Neu3 neuraminidase 3 MGI:1355305

Synonyms

ganglioside sialidase, membrane sialidase

Feature Type

protein coding gene

Genetic Map

Chromosome 7

54.15 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:99811439-99828417 bp, - strand From NCBI annotation of GRCm38   16979 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4847  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 5 zebrafish

Gene Tree: Neu3

Human homologs

Human Homolog		NEU3, sialidase 3 (membrane sialidase)
NCBI Gene ID		10825
neXtProt AC		NX_Q9UQ49
Human Synonyms		SIAL3
Human Chr (Location)		11q13.5; chr11:74699950-74718743 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit decreased colon carcinogenesis induced by azoxymethane and dextran sodium sulfate.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	carbohydrate metabolic process, metabolic process
Component	membrane, plasma membrane
Function	alpha-sialidase activity, exo-alpha-(2->3)-sialidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (7)    Tissues (5)   
Theiler Stages: 20, 22, 24, 26, 28

Assay Type	Results
RT-PCR	7

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000035239 (Evidence)
Entrez Gene	50877 (Evidence)
UniGene	103703
DFCI	TC1586763
DoTS	DT.55122594
NIA Mouse Gene Index	U028897
EC	3.2.1.18
Consensus CDS Project	CCDS21489.1
International Mouse Knockout Project Status	Neu3

Sequences

Length	Strain/Species
genomic	50877	NCBI Gene Model | MGI Sequence Detail	16979	C57BL/6J
transcript	NM_016720	RefSeq | MGI Sequence Detail	3341	C57BL/6
polypeptide	Q9JMH7	UniProt | EBI | MGI Sequence Detail	418	Not Applicable

All sequences(17) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(76 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026944	Sialidase-3
InterPro	IPR026856	Sialidase family
InterPro	IPR011040	Sialidases
Protein Ontology	PR:000011147	sialidase-3

Graphical View of Protein Domain Structure

References

(Earliest) J:61065 Hasegawa T, et al., Molecular cloning of mouse ganglioside sialidase and its increased expression in Neuro2a cell differentiation [published erratum appears in J Biol Chem 2000 May 12;275(19):14778]. J Biol Chem. 2000 Mar 17;275(11):8007-15
(Latest) J:189604 Yamaguchi K, et al., Reduced susceptibility to colitis-associated colon carcinogenesis in mice lacking plasma membrane-associated sialidase. PLoS One. 2012;7(7):e41132
All references(34)