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Galns
Gene Detail
 Symbol
Name
ID
Galns
galactosamine (N-acetyl)-6-sulfate sulfatase
MGI:1355303
Synonyms N-acetylgalactosamine-6-sulfate sulfatase
Feature Type protein coding gene
Genetic Map
Chromosome 8
71.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:122578238-122611487 bp, - strand
From Ensembl annotation of GRCm38

  33250 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55468  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: arylsulfatase-like protein
Gene Tree: Galns

Human
homologs
Human Homolog GALNS, galactosamine (N-acetyl)-6-sulfate sulfatase
NCBI Gene ID 2588
neXtProt AC  NX_P34059
Human Synonyms  GalN6S, GALNAC6S, GAS, MPS4A
Human Chr (Location)  16q24.3; chr16:88813734-88856966 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GALNS
Alleles
and
phenotypes
All alleles(6) : Targeted(5) Gene trapped(1)
 
Homozygous mutant mice are viable, fertile, and healthy in spite of lysosmal storage.
 
Human Diseases Modeled Using Mouse Galns (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process metabolic process
Component lysosome
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (104)    Tissues (102)    Images (4)
Theiler Stages: 20, 22, 24
Assay TypeResults
RNA in situ 104
cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(51) cDNA(51)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000015027 (Evidence)
Entrez Gene50917 (Evidence)
UniGene34702
DFCITC1580392, TC1595487, TC1648692, TC1686154
DoTSDT.101400281, DT.110857287, DT.529848, DT.94244412
NIA Mouse Gene IndexU030360
EC3.1.6.4
Consensus CDS ProjectCCDS40504.1
International Mouse Knockout Project StatusGalns
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000015027 Ensembl Gene Model | MGI Sequence Detail 33250 C57BL/6J ±  kb
transcript ENSMUST00000015171 Ensembl | MGI Sequence Detail 2585 Not Applicable 
polypeptide ENSMUSP00000015171 Ensembl | MGI Sequence Detail 520 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(13) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(470 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
InterPro IPR000917 Sulfatase
InterPro IPR024607 Sulfatase, conserved site
Protein Ontology PR:000007817 N-acetylgalactosamine-6-sulfatase
References (Earliest) J:60994 Montano AM, et al., The mouse N-acetylgalactosamine-6-sulfate sulfatase (Galns) gene: cDNA isolation, genomic characterization, chromosomal assignment and analysis of the 5'-flanking region. Biochim Biophys Acta. 2000 Mar 17;1500(3):323-34
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory