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Galns Gene Detail
Summary
  • Symbol
    Galns
  • Name
    galactosamine (N-acetyl)-6-sulfate sulfatase
  • Synonyms
    N-acetylgalactosamine-6-sulfate sulfatase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355303
    NCBI Gene: 50917
  • Gene Overview
    MyGene.info: GALNS
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:122578242-122611463 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 71.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    470 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355303
protein coding gene Chr8:122578237-122611503 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034232
protein coding gene Chr8:126130949-126172151 (-)
A/J MGP_AJ_G0034212
protein coding gene Chr8:120906401-120941463 (-)
AKR/J MGP_AKRJ_G0034139
protein coding gene Chr8:124428991-124468094 (-)
BALB/cJ MGP_BALBcJ_G0034206
protein coding gene Chr8:121106928-121140999 (-)
C3H/HeJ MGP_C3HHeJ_G0033917
protein coding gene Chr8:125129282-125169615 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034726
protein coding gene Chr8:130343944-130379652 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031668
protein coding gene Chr8:113740857-113773168 (-)
CAST/EiJ MGP_CASTEiJ_G0033244
protein coding gene Chr8:125213569-125248361 (-)
CBA/J MGP_CBAJ_G0033890
protein coding gene Chr8:135125635-135168327 (-)
DBA/2J MGP_DBA2J_G0034046
protein coding gene Chr8:120095467-120130167 (-)
FVB/NJ MGP_FVBNJ_G0033989
protein coding gene Chr8:119241702-119276644 (-)
LP/J MGP_LPJ_G0034135
protein coding gene Chr8:126253805-126296509 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034036
protein coding gene Chr8:137294008-137332028 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034744
protein coding gene Chr8:124613350-124650155 (-)
PWK/PhJ MGP_PWKPhJ_G0032946
protein coding gene Chr8:119919831-119953282 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032786
protein coding gene Chr8:123343398-123378744 (-)
WSB/EiJ MGP_WSBEiJ_G0033360
protein coding gene Chr8:125368147-125405064 (-)



Homology
more
  • Human Ortholog
    GALNS, galactosamine (N-acetyl)-6-sulfatase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GALNS, galactosamine (N-acetyl)-6-sulfatase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GalN6S, GALNAC6S, GAS, MPS4A
  • Links
    NCBI Gene ID: 2588
    neXtProt AC: NX_P34059
    UniProt: P34059

  • Chr Location
    16q24.3; chr16:88813734-88856970 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Galns mouse models; 1 with human GALNS associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable, fertile, and healthy in spite of lysosmal storage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015027 Ensembl Gene Model | MGI Sequence Detail 33222 C57BL/6J ±  kb
    transcript ENSMUST00000015171 Ensembl | MGI Sequence Detail 2557 Not Applicable  
    polypeptide ENSMUSP00000015171 Ensembl | MGI Sequence Detail 520 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 52

      Microarray probesets 3
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:60994 Montano AM, et al., The mouse N-acetylgalactosamine-6-sulfate sulfatase (Galns) gene: cDNA isolation, genomic characterization, chromosomal assignment and analysis of the 5'-flanking region. Biochim Biophys Acta. 2000 Mar 17;1500(3):323-34
    • Latest
      J:220052 Tomatsu S, et al., Enzyme replacement therapy in newborn mucopolysaccharidosis IVA mice: early treatment rescues bone lesions?. Mol Genet Metab. 2015 Feb;114(2):195-202

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory