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Galns
Gene Detail
Symbol

Name
ID
Galns
galactosamine (N-acetyl)-6-sulfate sulfatase
MGI:1355303
Synonyms
N-acetylgalactosamine-6-sulfate sulfatase
Feature Type
protein coding gene
Genetic Map
Chromosome 8
71.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:122578238-122611487 bp, - strand
From Ensembl annotation of GRCm38

  33250 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55468  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GALNS
Protein SuperFamily: arylsulfatase-like protein
Gene Tree: Galns

Human
homologs
GALNS, galactosamine (N-acetyl)-6-sulfatase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2588
neXtProt AC: NX_P34059

Human Synonyms: GalN6S, GALNAC6S, GAS, MPS4A

Human Chr (Location): 16q24.3; chr16:88813734-88856966 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GALNS

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice are viable, fertile, and healthy in spite of lysosmal storage.
 
Human Diseases Modeled in Mice Using Galns (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Galns interacts with 122 markers (Mir10a, Mir10b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process metabolic process
Component extracellular exosome, lysosome
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (104)    Tissues (102)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 104
cDNA source data(51)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase galns    NEW 
Molecular
reagents
All nucleic(51) cDNA(51)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000015027 (Evidence)
Entrez Gene 50917 (Evidence)
UniGene 34702
DFCI TC1580392, TC1595487, TC1648692, TC1686154
DoTS DT.101400281, DT.110857287, DT.529848, DT.94244412
NIA Mouse Gene Index U030360
EC 3.1.6.4
Consensus CDS Project CCDS40504.1
International Mouse Phenotyping Consortium Status Galns
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000015027 Ensembl Gene Model | MGI Sequence Detail 33250 C57BL/6J ±  kb
transcript ENSMUST00000015171 Ensembl | MGI Sequence Detail 2585 Not Applicable 
polypeptide ENSMUSP00000015171 Ensembl | MGI Sequence Detail 520 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(10) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(470 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
InterPro IPR000917 Sulfatase
InterPro IPR024607 Sulfatase, conserved site
Protein Ontology PR:000007817 N-acetylgalactosamine-6-sulfatase
References
(Earliest) J:60994 Montano AM, et al., The mouse N-acetylgalactosamine-6-sulfate sulfatase (Galns) gene: cDNA isolation, genomic characterization, chromosomal assignment and analysis of the 5'-flanking region. Biochim Biophys Acta. 2000 Mar 17;1500(3):323-34
(Latest) J:220052 Tomatsu S, et al., Enzyme replacement therapy in newborn mucopolysaccharidosis IVA mice: early treatment rescues bone lesions?. Mol Genet Metab. 2015 Feb;114(2):195-202
All references(32)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory