About   Help   FAQ
Galns Gene Detail
Summary
  • Symbol
    Galns
  • Name
    galactosamine (N-acetyl)-6-sulfate sulfatase
  • Synonyms
    N-acetylgalactosamine-6-sulfate sulfatase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355303
    NCBI Gene: 50917
  • Gene Overview
    MyGene.info: GALNS
Location & Maps
more
  • Sequence Map
    Chr8:122578238-122611487 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33250 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 71.91 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GALNS, galactosamine (N-acetyl)-6-sulfatase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GALNS, galactosamine (N-acetyl)-6-sulfatase
    Orthology source: HomoloGene
  • Synonyms
    GalN6S, GALNAC6S, GAS, MPS4A
  • Links
    NCBI Gene ID: 2588
    neXtProt AC: NX_P34059

  • Chr Location
    16q24.3; chr16:88813734-88856966 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Galns mouse models; 1 with human GALNS associations

Human Disease Mouse Models
       Mucopolysaccharidosis, Type IVA; MPS4A   OMIM: 253000 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable, fertile, and healthy in spite of lysosmal storage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000015027 Ensembl Gene Model | MGI Sequence Detail 33250 C57BL/6J ±  kb
transcript ENSMUST00000015171 Ensembl | MGI Sequence Detail 2585 Not Applicable  
polypeptide ENSMUSP00000015171 Ensembl | MGI Sequence Detail 520 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    470 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007817 N-acetylgalactosamine-6-sulfatase
  • EC
  • InterPro Domains
    IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
    IPR017850 Alkaline-phosphatase-like, core domain
    IPR024607 Sulfatase, conserved site
    IPR000917 Sulfatase, N-terminal
Molecular
Reagents
less
  • All nucleic 51
    cDNA 51

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Diseases 3
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:60994 Montano AM, et al., The mouse N-acetylgalactosamine-6-sulfate sulfatase (Galns) gene: cDNA isolation, genomic characterization, chromosomal assignment and analysis of the 5'-flanking region. Biochim Biophys Acta. 2000 Mar 17;1500(3):323-34
  • Latest
    J:220052 Tomatsu S, et al., Enzyme replacement therapy in newborn mucopolysaccharidosis IVA mice: early treatment rescues bone lesions?. Mol Genet Metab. 2015 Feb;114(2):195-202

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory