Galns
Gene Detail

Symbol Name ID

Galns galactosamine (N-acetyl)-6-sulfate sulfatase MGI:1355303

Synonyms

N-acetylgalactosamine-6-sulfate sulfatase

Feature Type

protein coding gene

Genetic Map

Chromosome 8

71.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:122578238-122611487 bp, - strand From Ensembl annotation of GRCm38   33250 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55468  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: arylsulfatase-like protein
Gene Tree: Galns

Human homologs

Human Homolog		GALNS, galactosamine (N-acetyl)-6-sulfate sulfatase
NCBI Gene ID		2588
neXtProt AC		NX_P34059
Human Synonyms		GalN6S, GALNAC6S, GAS, MPS4A
Human Chr (Location)		16q24.3; chr16:88880142-88923374 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GALNS

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Homozygous mutant mice are viable, fertile, and healthy in spite of lysosmal storage.

 
Human Diseases Modeled Using Mouse Galns (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	metabolic process
Component	lysosome
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (104)    Tissues (102)    Images (4)
Theiler Stages: 20, 22, 24

Assay Type	Results
RNA in situ	104

cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(51) cDNA(51)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000015027 (Evidence)
Entrez Gene	50917 (Evidence)
UniGene	34702
DFCI	TC1580392, TC1595487, TC1648692, TC1686154
DoTS	DT.101400281, DT.110857287, DT.529848, DT.94244412
NIA Mouse Gene Index	U030360
EC	3.1.6.4
Consensus CDS Project	CCDS40504.1
International Mouse Knockout Project Status	Galns

Sequences

Length	Strain/Species
genomic	ENSMUSG00000015027	Ensembl Gene Model | MGI Sequence Detail	33250	C57BL/6J
transcript	ENSMUST00000015171	Ensembl | MGI Sequence Detail	2585	Not Applicable
polypeptide	ENSMUSP00000015171	Ensembl | MGI Sequence Detail	520	Not Applicable

All sequences(32) RefSeq(4) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(243 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017849	Alkaline phosphatase-like, alpha/beta/alpha
InterPro	IPR017850	Alkaline-phosphatase-like, core domain
InterPro	IPR000917	Sulfatase
InterPro	IPR024607	Sulfatase, conserved site
Protein Ontology	PR:000007817	N-acetylgalactosamine-6-sulfatase

References

(Earliest) J:60994 Montano AM, et al., The mouse N-acetylgalactosamine-6-sulfate sulfatase (Galns) gene: cDNA isolation, genomic characterization, chromosomal assignment and analysis of the 5'-flanking region. Biochim Biophys Acta. 2000 Mar 17;1500(3):323-34
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(31)