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Klrg1 Gene Detail
Summary
  • Symbol
    Klrg1
  • Name
    killer cell lectin-like receptor subfamily G, member 1
  • Synonyms
    2F1-Ag
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355294
    NCBI Gene: 50928
  • Gene Overview
    MyGene.info: KLRG1
Location & Maps
more
  • Sequence Map
    Chr6:122270596-122282882 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12287 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 57.52 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KLRG1, killer cell lectin like receptor G1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KLRG1, killer cell lectin like receptor G1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    2F1, CLEC15A, MAFA, MAFA-2F1, MAFA-L, MAFA-LIKE
  • Links
    NCBI Gene ID: 10219
    neXtProt AC: NX_Q96E93

  • Chr Location
    12p13.31; chr12:8989625-9010747 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (ENU)
    1
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a null allele have no abnormal phenoptype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026937 VEGA Gene Model | MGI Sequence Detail 12287 C57BL/6J ±  kb
transcript OTTMUST00000066599 VEGA | MGI Sequence Detail 1414 Not Applicable  
polypeptide OTTMUSP00000033402 VEGA | MGI Sequence Detail 188 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    24 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 5
    cDNA 5

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:52111 Hanke T, et al., 2F1 antigen, the mouse homolog of the rat mast cell function-associated antigen, is a lectin-like type II transmembrane receptor expressed by natural killer cells. Eur J Immunol. 1998 Dec;28(12):4409-17
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory