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Klrg1 Gene Detail
Summary
  • Symbol
    Klrg1
  • Name
    killer cell lectin-like receptor subfamily G, member 1
  • Synonyms
    2F1-Ag
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355294
    NCBI Gene: 50928
  • Gene Overview
    MyGene.info: KLRG1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:122270596-122282833 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 57.52 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    23 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355294
protein coding gene Chr6:122270596-122282882 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031222
protein coding gene Chr6:125344599-125358207 (-)
A/J MGP_AJ_G0031192
protein coding gene Chr6:120595761-120607242 (-)
AKR/J MGP_AKRJ_G0031121
protein coding gene Chr6:123938314-123951320 (-)
BALB/cJ MGP_BALBcJ_G0031201
protein coding gene Chr6:120284478-120296299 (-)
C3H/HeJ MGP_C3HHeJ_G0030920
protein coding gene Chr6:123887827-123900671 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031660
protein coding gene Chr6:128625053-128640235 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028819
protein coding gene Chr6:117199181-117210411 (-)
CAST/EiJ MGP_CASTEiJ_G0030309
protein coding gene Chr6:124116452-124130595 (-)
CBA/J MGP_CBAJ_G0030884
protein coding gene Chr6:133658069-133670009 (-)
DBA/2J MGP_DBA2J_G0031040
protein coding gene Chr6:119519456-119532580 (-)
FVB/NJ MGP_FVBNJ_G0030992
protein coding gene Chr6:118461728-118473715 (-)
LP/J MGP_LPJ_G0031120
protein coding gene Chr6:125499121-125511039 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031027
protein coding gene Chr6:137630735-137643625 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031690
protein coding gene Chr6:123824950-123837053 (-)
PWK/PhJ MGP_PWKPhJ_G0030024
protein coding gene Chr6:118339654-118352973 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0030391
protein coding gene Chr6:124126833-124138700 (-)



Homology
more
  • Human Ortholog
    KLRG1, killer cell lectin like receptor G1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KLRG1, killer cell lectin like receptor G1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    2F1, CLEC15A, MAFA, MAFA-2F1, MAFA-L, MAFA-LIKE
  • Links
    NCBI Gene ID: 10219
    neXtProt AC: NX_Q96E93
    UniProt: Q96E93

  • Chr Location
    12p13.31; chr12:8989079-9255692 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Mice homozygous for a null allele have no abnormal phenoptype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 50928 NCBI Gene Model | MGI Sequence Detail 12238 C57BL/6J ±  kb
transcript NM_016970 RefSeq | MGI Sequence Detail 1374 CB17-Prkdc  
polypeptide O88713 UniProt | EBI | MGI Sequence Detail 188 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 3
References
more
  • Summaries
    All 54
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:52111 Hanke T, et al., 2F1 antigen, the mouse homolog of the rat mast cell function-associated antigen, is a lectin-like type II transmembrane receptor expressed by natural killer cells. Eur J Immunol. 1998 Dec;28(12):4409-17
  • Latest
    J:246418 Meinicke H, et al., Tumour-associated changes in intestinal epithelial cells cause local accumulation of KLRG1+ GATA3+ regulatory T cells in mice. Immunology. 2017 Sep;152(1):74-88

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory