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Il17rb Gene Detail
Summary
  • Symbol
    Il17rb
  • Name
    interleukin 17 receptor B
  • Synonyms
    Evi27, Il17br, IL-17ER, IL-17Rh1, IL17RH1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355292
    NCBI Gene: 50905
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:29718125-29730853 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 18.39 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    464 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355292
 protein coding gene Chr14:29718092-29730853 (-)
129S1/SvImJ ENSMUSG00200037283
 protein coding gene Chr14:21534670-21547430 (-)
A/J ENSMUSG00195012350
 protein coding gene Chr14:22608184-22620942 (-)
AKR/J ENSMUSG00220030903
 protein coding gene Chr14:21722777-21735537 (-)
BALB/cJ ENSMUSG00180021777
 protein coding gene Chr14:21696819-21709577 (-)
C3H/HeJ ENSMUSG00175034615
 protein coding gene Chr14:21764170-21776928 (-)
C57BL/6NJ ENSMUSG00215028575
 protein coding gene Chr14:22009088-22021849 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019047
 protein coding gene Chr14:22300980-22313730 (-)
CAST/EiJ ENSTCUG00005021850
 protein coding gene Chr14:21840590-21853394 (-)
CBA/J ENSMUSG00210033957
 protein coding gene Chr14:22007146-22019904 (-)
DBA/2J ENSMUSG00185038002
 protein coding gene Chr14:26283122-26295883 (-)
FVB/NJ ENSMUSG00205027043
 protein coding gene Chr14:21836344-21849102 (-)
JF1/MsJ ENSUMUG00000023080
 protein coding gene Chr14:33529257-33542078 (-)
LP/J ENSMUSG00230034588
 protein coding gene Chr14:33563423-33576183 (-)
NOD/ShiLtJ ENSMUSG00190017003
 protein coding gene Chr14:22020724-22033484 (-)
NZO/HlLtJ ENSMUSG00225037023
 protein coding gene Chr14:27895428-27908186 (-)
PWK/PhJ ENSLUMG00010019323
 protein coding gene Chr14:10133292-10146090 (-)
SPRET/EiJ ENSMSPG00010036727
 protein coding gene Chr14:23667572-23680315 (-)
WSB/EiJ ENSIUOG00005012115
 protein coding gene Chr14:21833399-21846206 (-)



Homology
more
  • Human Ortholog
    IL17RB, interleukin 17 receptor B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL17RB, interleukin 17 receptor B
  • Synonyms
    CRL4, EVI27, IL17BR, IL17RH1
  • Links
    NCBI Gene ID: 55540
    UniProt: Q9NRM6

  • Chr Location
    3p21.1; chr3:53845783-53866045 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 5 alleles in 7 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice that are homozygous for a null allele have defects in their response to IL17A or IL17F. In addition this locus is a common site of retoviral integration in BXH2 murine myeloid leukemias and occurred at a CpG island 6 kb upstream of the Il17rb gene.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    604
  • Tissues
    3
  • cDNA Data
    11
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50905 NCBI Gene Model | MGI Sequence Detail 12729 C57BL/6J ±  kb
    transcript NM_019583 RefSeq | MGI Sequence Detail 2061 ZRU/MplStud  
    polypeptide Q9JIP3 UniProt | EBI | MGI Sequence Detail 499 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 11

      Microarray probesets 3
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 44
    • Earliest
      J:58265 Li J, et al., Leukaemia disease genes: large-scale cloning and pathway predictions [see comments]. Nat Genet. 1999 Nov;23(3):348-53
    • Latest
      J:385318 Forster PM, et al., Blimp-1 integrates alarmin signals in ILC2s and drives proinflammatory functions required for type 2 immunity. J Exp Med. 2026 May 4;223(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory