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Tmod4 Gene Detail
Summary
  • Symbol
    Tmod4
  • Name
    tropomodulin 4
  • Synonyms
    MTMOD, skeletal tropomodulin, Sk-Tmod
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355285
    NCBI Gene: 50874
  • Gene Overview
    MyGene.info: TMOD4
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:95124476-95129209 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    46 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355285
protein coding gene Chr3:95122799-95129209 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027568
protein coding gene Chr3:95817719-95823484 (+)
A/J MGP_AJ_G0027527
protein coding gene Chr3:92862696-92868311 (+)
AKR/J MGP_AKRJ_G0027494
protein coding gene Chr3:95003920-95010760 (+)
BALB/cJ MGP_BALBcJ_G0027539
protein coding gene Chr3:92632969-92637535 (+)
C3H/HeJ MGP_C3HHeJ_G0027272
protein coding gene Chr3:95285933-95291039 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027987
protein coding gene Chr3:99384745-99389258 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025327
protein coding gene Chr3:89224795-89229526 (+)
CAST/EiJ MGP_CASTEiJ_G0026722
protein coding gene Chr3:94572825-94577335 (+)
CBA/J MGP_CBAJ_G0027249
protein coding gene Chr3:102990803-102995336 (+)
DBA/2J MGP_DBA2J_G0027388
protein coding gene Chr3:92155568-92160941 (+)
FVB/NJ MGP_FVBNJ_G0027359
protein coding gene Chr3:90224765-90230556 (+)
LP/J MGP_LPJ_G0027497
protein coding gene Chr3:97108325-97114501 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027386
protein coding gene Chr3:109114814-109119655 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028041
protein coding gene Chr3:94659719-94666498 (+)
PWK/PhJ MGP_PWKPhJ_G0026450
protein coding gene Chr3:92032688-92037191 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026271
protein coding gene Chr3:92954639-92961738 (+)
WSB/EiJ MGP_WSBEiJ_G0026804
protein coding gene Chr3:95045710-95050397 (+)



Homology
more
  • Human Ortholog
    TMOD4, tropomodulin 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TMOD4, tropomodulin 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SK-TMOD
  • Links
    NCBI Gene ID: 29765
    neXtProt AC: NX_Q9NZQ9
    UniProt: Q9NZQ9

  • Chr Location
    1q21.3; chr1:151169986-151176071 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Mice homozygous for a knock-out allele are viable, fertile and exhibit no overt myopathy, with normal thin filament lengths, myofibril organization, and skeletal muscle contractile function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005628 Ensembl Gene Model | MGI Sequence Detail 4734 C57BL/6J ±  kb
transcript ENSMUST00000005769 Ensembl | MGI Sequence Detail 1242 Not Applicable  
polypeptide ENSMUSP00000005769 Ensembl | MGI Sequence Detail 345 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 31
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:60558 Cox PR, et al., Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs. Genomics. 2000 Jan 1;63(1):97-107
  • Latest
    J:236433 Gokhin DS, et al., Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle. Development. 2015 Dec 15;142(24):4351-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory