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Irx4
Gene Detail
 Symbol
Name
ID
Irx4
Iroquois related homeobox 4 (Drosophila)
MGI:1355275
Feature Type protein coding gene
Genetic Map
Chromosome 13
39.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:73260479-73269608 bp, + strand
From VEGA annotation of GRCm38

  9130 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9485  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Irx4

Human
homologs
Human Homolog IRX4, iroquois homeobox 4
NCBI Gene ID 50805
neXtProt AC  NX_P78413
Human Synonyms  IRXA3
Human Chr (Location)  5p15.3; chr5:1877427-1887179 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit abnormal ventricular gene expression followed by cardiomyopathy with hypertrophy and impaired contractile function.
 
Interactions
Irx4 interacts with 126 markers (Mir17, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell differentiation, heart development, ...
Component nucleus, transcription factor complex
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (38 records)
Data Summary: Results (139)    Tissues (69)    Images (43)
Theiler Stages: 12, 13, 15, 17, 18, 20, 21, 22, 23, 27, 28
Assay TypeResults
RNA in situ 136
RT-PCR 3
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(10) Primer pair(1) Other(4)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000040088 (Evidence)
Ensembl Gene ModelENSMUSG00000021604 (Evidence)
Entrez Gene50916 (Evidence)
UniGene103784
DFCITC1589492
DoTSDT.87072242
NIA Mouse Gene IndexU014994
Consensus CDS ProjectCCDS26629.1
International Mouse Knockout Project StatusIrx4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040088 VEGA Gene Model | MGI Sequence Detail 9130 C57BL/6J ±  kb
transcript OTTMUST00000104131 VEGA | MGI Sequence Detail 2589 Not Applicable 
polypeptide OTTMUSP00000058244 VEGA | MGI Sequence Detail 515 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(12) UniProt(1)
Polymorphisms SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR008422 Homeobox KN domain
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003893 Iroquois-class homeodomain protein
Protein Ontology PR:000009110 iroquois-class homeodomain protein IRX-4
References (Earliest) J:59924 Bruneau BG, et al., Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand. Dev Biol. 2000 Jan 15;217(2):266-77
(Latest) J:198651 Wu SP, et al., Atrial identity is determined by a COUP-TFII regulatory network. Dev Cell. 2013 May 28;25(4):417-26
All references(61)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory