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Irx4
Gene Detail
Symbol

Name
ID
Irx4
Iroquois related homeobox 4 (Drosophila)
MGI:1355275
Feature Type
protein coding gene
Genetic Map
Chromosome 13
39.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:73260479-73269608 bp, + strand
From VEGA annotation of GRCm38

  9130 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9485  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IRX4
Gene Tree: Irx4

Human
homologs
IRX4, iroquois homeobox 4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 50805
neXtProt AC: NX_P78413

Human Synonyms: IRXA3

Human Chr (Location): 5p15.3; chr5:1877427-1887179 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit abnormal ventricular gene expression followed by cardiomyopathy with hypertrophy and impaired contractile function.
 
Interactions
Irx4 interacts with 126 markers (Mir17, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell differentiation, heart development, ...
Component nucleus, transcription factor complex
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (42 records)
Data Summary: Results (152)    Tissues (77)    Images (73)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 136
RT-PCR 3
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA IRX4 ; Xenbase irx4 ; ZFIN irx4a, irx4b    NEW 
Molecular
reagents
All nucleic(15) cDNA(10) Primer pair(1) Other(4)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000040088 (Evidence)
Ensembl Gene Model ENSMUSG00000021604 (Evidence)
Entrez Gene 50916 (Evidence)
UniGene 103784
DFCI TC1589492
DoTS DT.87072242
NIA Mouse Gene Index U014994
Consensus CDS Project CCDS26629.1
International Mouse Phenotyping Consortium Status Irx4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040088 VEGA Gene Model | MGI Sequence Detail 9130 C57BL/6J ±  kb
transcript OTTMUST00000104131 VEGA | MGI Sequence Detail 2589 Not Applicable 
polypeptide OTTMUSP00000058244 VEGA | MGI Sequence Detail 515 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(12) UniProt(1)
Polymorphisms
SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR008422 Homeobox KN domain
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003893 Iroquois-class homeodomain protein
Protein Ontology PR:000009110 iroquois-class homeodomain protein IRX-4
References
(Earliest) J:59924 Bruneau BG, et al., Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand. Dev Biol. 2000 Jan 15;217(2):266-77
(Latest) J:217617 Xiong Y, et al., Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development. J Clin Invest. 2014 Nov;124(11):4823-8
All references(64)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory