Capn15 MGI Mouse Gene Detail - MGI:1355075

Symbol

Capn15
Name

calpain 15
Synonyms

Solh

Feature Type

protein coding gene
IDs

MGI:1355075
NCBI Gene: 50817
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr17:26177338-26204753 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 13.04 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

719 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1355075	protein coding gene	Chr17:26177338-26204770 (-)
129S1/SvImJ	ENSMUSG00200047361	protein coding gene	Chr17:21622379-21649812 (-)
A/J	ENSMUSG00195054249	protein coding gene	Chr17:22639532-22666982 (-)
AKR/J	ENSMUSG00220052239	protein coding gene	Chr17:21686339-21713776 (-)
BALB/cJ	ENSMUSG00180049658	protein coding gene	Chr17:21920403-21947841 (-)
C3H/HeJ	ENSMUSG00175053574	protein coding gene	Chr17:21678581-21706010 (-)
C57BL/6NJ	ENSMUSG00215053212	protein coding gene	Chr17:21686951-21714379 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021268	protein coding gene	Chr17:21796532-21823155 (-)
CAST/EiJ	ENSTCUG00005047871	protein coding gene	Chr17:22268288-22296547 (-)
CBA/J	ENSMUSG00210049382	protein coding gene	Chr17:21517419-21544848 (-)
DBA/2J	ENSMUSG00185052543	protein coding gene	Chr17:23727776-23755225 (-)
FVB/NJ	ENSMUSG00205025569	protein coding gene	Chr17:21983508-22010941 (-)
JF1/MsJ	ENSUMUG00000054788	protein coding gene	Chr17:23182979-23211248 (-)
LP/J	ENSMUSG00230054609	protein coding gene	Chr17:25126910-25154343 (-)
NOD/ShiLtJ	ENSMUSG00190041481	protein coding gene	Chr17:21616498-21643946 (-)
NZO/HlLtJ	ENSMUSG00225053995	protein coding gene	Chr17:27046845-27074293 (-)
PWK/PhJ	ENSLUMG00010045775	protein coding gene	Chr17:21102129-21130311 (-)
SPRET/EiJ	ENSMSPG00010047809	protein coding gene	Chr17:22420104-22448583 (-)
WSB/EiJ	ENSIUOG00005050836	protein coding gene	Chr17:22360171-22387664 (-)

Human Ortholog

CAPN15, calpain 15

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CAPN15, calpain 15
Synonyms

OGIN, SOLH
Links

HGNC:11182

NCBI Gene ID: 6650

UniProt: O75808
Chr Location

16p13.3; chr16:527712-554636 (+) GRCh38

MGI Vertebrate Homology

Capn15 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CAPN15
Gene Tree

Capn15

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

4
Gene trapped

7
Radiation induced

2
Targeted

4
Genomic Mutations

2 involving Capn15
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit partial preweaning lethality, reduced body weight, and eye defects.

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

638
Tissues

27
cDNA Data

18
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase capn15

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All Sequences

93
RefSeq

20
UniProt

4
CCDS

CCDS28540.1, CCDS84286.1

Ensembl

ENSMUSG00000037326 (Evidence)
NCBI Gene

50817

			Length	Strain/Species	Flank
genomic	50817	NCBI Gene Model \| MGI Sequence Detail	27416	C57BL/6J	± kb
transcript	NM_001347334	RefSeq \| MGI Sequence Detail	5182	C57BL/6
polypeptide	Q9JLG8	UniProt \| EBI \| MGI Sequence Detail	1095	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015404 calpain-15

(term hierarchy)
EC

3.4.22.-
InterPro Domains

IPR060025 Calpain15, C-terminal domain

IPR000169 Cysteine peptidase, cysteine active site

IPR053000 DNA-dependent metalloprotease WSS1-like

IPR038765 Papain-like cysteine peptidase superfamily

IPR001300 Peptidase C2, calpain, catalytic domain

IPR022684 Peptidase C2, calpain family

IPR001876 Zinc finger, RanBP2-type

IPR036443 Zinc finger, RanBP2-type superfamily

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All nucleic 21

Genomic 2

cDNA 19

Antibodies 1

Microarray probesets 5

Summaries

All 43

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 15
Earliest

J:61079 Kamei M, et al., Solh, the mouse homologue of the Drosophila melanogaster small optic lobes gene: organization, chromosomal mapping, and localization of gene product to the olfactory bulb. Genomics. 2000 Feb 15;64(1):82-9
Latest

J:385569 Noguchi A, et al., CAPN15 is a non-proteasomal, ubiquitin-directed calpain protease that regulates cell adhesion by cleaving E-cadherin. J Biol Chem. 2026 Jan;302(1):111034

TSS for Capn15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146888	Chr17:26204747-26204769 (-)	-5 bp
Tssr146887	Chr17:26204615-26204746 (-)	72 bp
Tssr146886	Chr17:26204597-26204608 (-)	150 bp
Tssr146885	Chr17:26198910-26198924 (-)	5,836 bp
Tssr146884	Chr17:26198861-26198872 (-)	5,886 bp
Tssr146883	Chr17:26191058-26191062 (-)	13,693 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24