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Dkkl1
Gene Detail
 Symbol
Name
ID
Dkkl1
dickkopf-like 1
MGI:1354963
Synonyms mSgy, SGY1, SGY-1, Soggy
Feature Type protein coding gene
Genetic Map
Chromosome 7
29.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:45207525-45211883 bp, - strand
From NCBI annotation of GRCm38

  4359 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56674  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Dkkl1

Human
homologs
Human Homolog DKKL1, dickkopf-like 1
NCBI Gene ID 27120
neXtProt AC  NX_Q9UK85
Human Synonyms  CT34, SGY, SGY1, SGY-1
Human Chr (Location)  19q13.33; chr19:49360503-49375116 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit increased sperm count associated with decreased sperm apoptosis. Mice homozygous for a different knock-out allele exhibit decreased fertilization frequency in vitro and delayed fertilizatio in vivo.
 
Interactions
Dkkl1 interacts with 6 markers (Mir325, Mir379, Mir411, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process positive regulation of fat cell differentiation
Component extracellular region
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (10)    Tissues (9)   
Theiler Stages: 11, 15, 20, 28
Assay TypeResults
RT-PCR 10
cDNA source data(101)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(103) cDNA(102) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030792 (Evidence)
Entrez Gene50722 (Evidence)
UniGene27287
DFCITC1578212
DoTSDT.530852, DT.94295158
NIA Mouse Gene IndexU028521
Consensus CDS ProjectCCDS21235.1
International Mouse Knockout Project StatusDkkl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 50722 NCBI Gene Model | MGI Sequence Detail 4359 C57BL/6J ±  kb
transcript NM_015789 RefSeq | MGI Sequence Detail 903 C57BL/6 
polypeptide Q9QZL9 UniProt | EBI | MGI Sequence Detail 230 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(58 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000006503 dickkopf-like protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:58147 Krupnik VE, et al., Functional and structural diversity of the human Dickkopf gene family. Gene. 1999 Oct 1;238(2):301-13
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(42)
Other
accession IDs
MGI:2140257

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory