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Dkkl1 Gene Detail
Summary
  • Symbol
    Dkkl1
  • Name
    dickkopf-like 1
  • Synonyms
    mSgy, SGY1, SGY-1, Soggy
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354963
    NCBI Gene: 50722
Location & Maps
more
  • Sequence Map
    Chr7:45207525-45211883 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4359 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.19 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DKKL1, dickkopf like acrosomal protein 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DKKL1, dickkopf like acrosomal protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CT34, SGY, SGY1, SGY-1
  • Links
    NCBI Gene ID: 27120
    neXtProt AC: NX_Q9UK85

  • Chr Location
    19q13.33; chr19:49360495-49375119 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    3
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a null allele exhibit increased sperm count associated with decreased sperm apoptosis. Mice homozygous for a different knock-out allele exhibit decreased fertilization frequency in vitro and delayed fertilizatio in vivo.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030792 Ensembl Gene Model | MGI Sequence Detail 4359 C57BL/6J ±  kb
transcript ENSMUST00000033057 Ensembl | MGI Sequence Detail 903 Not Applicable  
polypeptide ENSMUSP00000033057 Ensembl | MGI Sequence Detail 230 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    62 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006503 dickkopf-like protein 1
Molecular
Reagents
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  • All nucleic 103
    cDNA 102
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2140257
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:58147 Krupnik VE, et al., Functional and structural diversity of the human Dickkopf gene family. Gene. 1999 Oct 1;238(2):301-13
  • Latest
    J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory