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Hs6st2
Gene Detail
Symbol

Name
ID
Hs6st2
heparan sulfate 6-O-sulfotransferase 2
MGI:1354959
Synonyms
6OST2
Feature Type
protein coding gene
Genetic Map
Chromosome X
28.04 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:51387212-51681856 bp, - strand
From VEGA annotation of GRCm38

  294645 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9277  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HS6ST2
Gene Tree: Hs6st2

Human
homologs
HS6ST2, heparan sulfate 6-O-sulfotransferase 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 90161
neXtProt AC: NX_Q96MM7

Human Chr (Location): Xq26.2; chrX:132626010-132961395 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from CvDC )
 
Female homozygous or male hemizygous mice for a disruption in this gene display a normal phenotype.
 
Interactions
Hs6st2 interacts with 332 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Expression
Literature Summary: (12 records)
Data Summary: Results (341)    Tissues (212)    Images (89)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 310
RT-PCR 31
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HS6ST2 ZFIN hs6st2    NEW 
Molecular
reagents
All nucleic(23) cDNA(17) Primer pair(6)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000017337 (Evidence)
Ensembl Gene Model ENSMUSG00000062184 (Evidence)
Entrez Gene 50786 (Evidence)
DFCI TC1650070, TC1591327, TC1577814, TC1707269
DoTS DT.101380112, DT.101249087, DT.527274, DT.111027429
NIA Mouse Gene Index U359449, U041240
EC 2.8.2.-
Consensus CDS Project CCDS40970.1, CCDS72379.1
International Mouse Phenotyping Consortium Status Hs6st2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017337 VEGA Gene Model | MGI Sequence Detail 294645 C57BL/6J ±  kb
transcript OTTMUST00000042462 VEGA | MGI Sequence Detail 4318 Not Applicable 
polypeptide OTTMUSP00000019086 VEGA | MGI Sequence Detail 652 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(14) UniProt(1)
Polymorphisms
SNPs within 2kb(755 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010635 Heparan sulphate 6-sulfotransferase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR005331 Sulfotransferase
Protein Ontology PR:000008766 heparan-sulfate 6-O-sulfotransferase 2
References
(Earliest) J:60682 Habuchi H, et al., The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. J Biol Chem. 2000 Jan 28;275(4):2859-68
(Latest) J:214343 Cai Z, et al., Role of heparan sulfate proteoglycans in optic disc and stalk morphogenesis. Dev Dyn. 2014 Oct;243(10):1310-6
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory