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Hs6st2 Gene Detail
Summary
  • Symbol
    Hs6st2
  • Name
    heparan sulfate 6-O-sulfotransferase 2
  • Synonyms
    6OST2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354959
    NCBI Gene: 50786
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:51387212-51681856 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 28.04 cM, cytoband A3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    755 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354959
protein coding gene ChrX:51386637-51681856 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035712
protein coding gene ChrX:46564576-46867564 (-)
A/J MGP_AJ_G0035695
protein coding gene ChrX:46421612-46719363 (-)
AKR/J MGP_AKRJ_G0035615
protein coding gene ChrX:47712408-48024689 (-)
BALB/cJ MGP_BALBcJ_G0035681
protein coding gene ChrX:46011204-46299514 (-)
C3H/HeJ MGP_C3HHeJ_G0035385
protein coding gene ChrX:46824632-47130621 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036211
protein coding gene ChrX:47670342-47971468 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033062
protein coding gene ChrX:43964589-44244564 (-)
CAST/EiJ MGP_CASTEiJ_G0034676
protein coding gene ChrX:34277265-34572980 (-)
CBA/J MGP_CBAJ_G0035359
protein coding gene ChrX:49007150-49323812 (-)
DBA/2J MGP_DBA2J_G0035514
protein coding gene ChrX:46261329-46553721 (-)
FVB/NJ MGP_FVBNJ_G0035462
protein coding gene ChrX:45954423-46246833 (-)
LP/J MGP_LPJ_G0035601
protein coding gene ChrX:46893372-47178401 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035501
protein coding gene ChrX:50548638-50868738 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036228
protein coding gene ChrX:46470322-46766066 (-)
PWK/PhJ MGP_PWKPhJ_G0034375
protein coding gene ChrX:33784579-34079401 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034220
protein coding gene ChrX:35053364-35354940 (-)
WSB/EiJ MGP_WSBEiJ_G0034820
protein coding gene ChrX:46005687-46301814 (-)



Homology
more
  • Human Ortholog
    HS6ST2, heparan sulfate 6-O-sulfotransferase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HS6ST2, heparan sulfate 6-O-sulfotransferase 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 90161
    neXtProt AC: NX_Q96MM7
    UniProt: Q96MM7

  • Chr Location
    Xq26.2; chrX:132626010-132961395 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9277
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HS6ST2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    9 phenotype references
Female homozygous or male hemizygous mice for a disruption in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000062184 Ensembl Gene Model | MGI Sequence Detail 294645 C57BL/6J ±  kb
transcript ENSMUST00000088172 Ensembl | MGI Sequence Detail 4318 Not Applicable  
polypeptide ENSMUSP00000085497 Ensembl | MGI Sequence Detail 652 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 18
    Primer pair 6

    Microarray probesets 4
References
more
  • Summaries
    All 46
    Developmental Gene Expression 16
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:60682 Habuchi H, et al., The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. J Biol Chem. 2000 Jan 28;275(4):2859-68
  • Latest
    J:252096 Paul A, et al., Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity. Cell. 2017 Oct 19;171(3):522-539.e20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory