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Hs6st2
Gene Detail
 Symbol
Name
ID
Hs6st2
heparan sulfate 6-O-sulfotransferase 2
MGI:1354959
Synonyms 6OST2
Feature Type protein coding gene
Genetic Map
Chromosome X
28.04 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:51387212-51681856 bp, - strand
From VEGA annotation of GRCm38

  294645 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9277  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hs6st2

Human
homologs
Human Homolog HS6ST2, heparan sulfate 6-O-sulfotransferase 2
NCBI Gene ID 90161
neXtProt AC  NX_Q96MM7
Human Chr (Location)  Xq26.2; chrX:132626010-132961395 (-)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Gene trapped(1) Targeted(3)
 
Female homozygous or male hemizygous mice for a disruption in this gene display a normal phenotype.
 
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process heparan sulfate proteoglycan biosynthetic process, enzymatic modification
Component extracellular vesicular exosome, integral component of membrane, ...
Function 1-hydroxypyrene sulfotransferase activity, 1-phenanthrol sulfotransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (339)    Tissues (206)    Images (87)
Theiler Stages: 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 308
RT-PCR 31
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(21) cDNA(16) Primer pair(5)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017337 (Evidence)
Ensembl Gene ModelENSMUSG00000062184 (Evidence)
Entrez Gene50786 (Evidence)
DFCITC1577814, TC1591327, TC1650070, TC1707269
DoTSDT.101249087, DT.101380112, DT.111027429, DT.527274
NIA Mouse Gene IndexU041240, U359449
EC2.8.2.-
Consensus CDS ProjectCCDS40970.1, CCDS72379.1
International Mouse Knockout Project StatusHs6st2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017337 VEGA Gene Model | MGI Sequence Detail 294645 C57BL/6J ±  kb
transcript OTTMUST00000042462 VEGA | MGI Sequence Detail 4318 Not Applicable 
polypeptide OTTMUSP00000019086 VEGA | MGI Sequence Detail 652 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(14) UniProt(1)
Polymorphisms SNPs within 2kb(755 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010635 Heparan sulphate 6-sulfotransferase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR005331 Sulfotransferase
Protein Ontology PR:000008766 heparan-sulfate 6-O-sulfotransferase 2
References (Earliest) J:60682 Habuchi H, et al., The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. J Biol Chem. 2000 Jan 28;275(4):2859-68
(Latest) J:195563 Anower-E-Khuda MF, et al., Heparan sulfate 6-O-sulfotransferase isoform-dependent regulatory effects of heparin on the activities of various proteases in mast cells and the biosynthesis of 6-O-sulfated heparin. J Biol Chem. 2013 Feb 8;288(6):3705-17
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory