Hs6st2
Gene Detail

Symbol Name ID

Hs6st2 heparan sulfate 6-O-sulfotransferase 2 MGI:1354959

Synonyms

6OST2

Feature Type

protein coding gene

Genetic Map

Chromosome X

28.04 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

ChrX:51387212-51681856 bp, - strand From VEGA annotation of GRCm38   294645 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Hs6st2 ± 2 cM)

Gene Tree: Hs6st2

Human ortholog

HS6ST2 heparan sulfate 6-O-sulfotransferase 2 NCBI Gene ID 90161
Human ChrX:131760038-132095423 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Female homozygous or male hemizygous mice for a disruption in this gene display a normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	metabolic process
Component	integral to membrane, membrane
Function	sulfotransferase activity, transferase activity

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (339)    Tissues (206)    Images (87)
Theiler Stages: 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	308
RT-PCR	31

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(16) Primer pair(5)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000017337 (Evidence)
Ensembl Gene Model	ENSMUSG00000062184 (Evidence)
Entrez Gene	50786 (Evidence)
DFCI	TC1577814, TC1591327, TC1650070, TC1707269
DoTS	DT.101249087, DT.101380112, DT.111027429, DT.527274
NIA Mouse Gene Index	U041240, U359449
EC	2.8.2.-
Consensus CDS Project	CCDS40970.1
International Mouse Knockout Project Status	Hs6st2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017337	VEGA Gene Model | MGI Sequence Detail	294645	C57BL/6J
transcript	OTTMUST00000042462	VEGA | MGI Sequence Detail	4318	Not Applicable
polypeptide	OTTMUSP00000019086	VEGA | MGI Sequence Detail	652	Not Applicable

All sequences(47) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(715 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR010635	Heparan sulphate 6-sulfotransferase
InterPro	IPR005331	Sulfotransferase
Protein Ontology	PR:000008766	heparan-sulfate 6-O-sulfotransferase 2

References

(Earliest) J:60682 Habuchi H, et al., The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. J Biol Chem. 2000 Jan 28;275(4):2859-68
(Latest) J:185652 Qu X, et al., Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development. Development. 2012 Aug;139(15):2730-9
All references(37)