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Nt5c Gene Detail
Summary
  • Symbol
    Nt5c
  • Name
    5',3'-nucleotidase, cytosolic
  • Synonyms
    Dnt, Dnt1, Umph2, Umph-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354954
    NCBI Gene: 50773
  • Gene Overview
    MyGene.info: NT5C
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:115490420-115491862 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 80.84 cM, cytoband E
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354954
protein coding gene Chr11:115490420-115491875 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019390
protein coding gene Chr11:119517437-119518879 (-)
A/J MGP_AJ_G0019359
protein coding gene Chr11:114299313-114300753 (-)
AKR/J MGP_AKRJ_G0019329
protein coding gene Chr11:117705989-117707429 (-)
BALB/cJ MGP_BALBcJ_G0019333
protein coding gene Chr11:114719674-114721116 (-)
C3H/HeJ MGP_C3HHeJ_G0019139
protein coding gene Chr11:118056769-118058209 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019783
protein coding gene Chr11:123159029-123160471 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017406
protein coding gene Chr11:111335989-111337437 (-)
CAST/EiJ MGP_CASTEiJ_G0018694
protein coding gene Chr11:119374438-119375880 (-)
CBA/J MGP_CBAJ_G0019111
protein coding gene Chr11:128016760-128018200 (-)
DBA/2J MGP_DBA2J_G0019222
protein coding gene Chr11:113734469-113735911 (-)
FVB/NJ MGP_FVBNJ_G0019214
protein coding gene Chr11:113214165-113215603 (-)
LP/J MGP_LPJ_G0019292
protein coding gene Chr11:119901301-119902741 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019247
protein coding gene Chr11:127185675-127187117 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019821
protein coding gene Chr11:118361902-118363344 (-)
PWK/PhJ MGP_PWKPhJ_G0018458
protein coding gene Chr11:115017593-115019029 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018251
protein coding gene Chr11:118118347-118119601 (-)
WSB/EiJ MGP_WSBEiJ_G0018746
protein coding gene Chr11:118316124-118317568 (-)



Homology
more
  • Human Ortholog
    NT5C, 5', 3'-nucleotidase, cytosolic
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NT5C, 5', 3'-nucleotidase, cytosolic
    Orthology source: HGNC, HomoloGene
  • Synonyms
    cdN, DNT, dNT-1, DNT1, HEL74, P5N2, PN-I, PN-II, UMPH2
  • Links
    NCBI Gene ID: 30833
    neXtProt AC: NX_Q8TCD5
    UniProt: Q8TCD5

  • Chr Location
    17q25.1; chr17:75130225-75131965 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020736 Ensembl Gene Model | MGI Sequence Detail 1443 C57BL/6J ±  kb
transcript ENSMUST00000021082 Ensembl | MGI Sequence Detail 858 Not Applicable  
polypeptide ENSMUSP00000021082 Ensembl | MGI Sequence Detail 200 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    Genomic 1
    cDNA 40

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15351, MGD-MRK-15353, MGI:98903
References
more
  • Summaries
    All 42
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:7039 Swallow DM, et al., Isozymes of rodent 5'-nucleotidase: evidence for two independent structural loci Umph-1 and Umph-2. Ann Hum Genet. 1983 Jan;47 Pt 1:9-17
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory