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Dkk3
Gene Detail
 Symbol
Name
ID
Dkk3
dickkopf homolog 3 (Xenopus laevis)
MGI:1354952
Feature Type protein coding gene
Genetic Map
Chromosome 7
58.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:112116019-112159057 bp, - strand
From NCBI annotation of GRCm38

  43039 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8303  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: Dickkopf-related protein 3 (Dkk-3)
Gene Tree: Dkk3

Human
homologs
Human Homolog DKK3, dickkopf WNT signaling pathway inhibitor 3
NCBI Gene ID 27122
neXtProt AC  NX_Q9UBP4
Human Synonyms  REIC, RIG
Human Chr (Location)  11p15.2; chr11:11962996-12009826 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable, fertile and euthyroid but exhibit hyperactivity, a slight but significant decrease in the frequency of natural killer cells, and significantly increased IgM, hemoglobin, and hematocrit levels.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Dkk3 interacts with 253 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process multicellular organismal development, negative regulation of aldosterone biosynthetic process, ...
Component extracellular region, extracellular space
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (529)    Tissues (338)    Images (148)
Theiler Stages: 1, 2, 3, 5, 8, 9, 11, 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 491
RT-PCR 34
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(16) Primer pair(8) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000030772 (Evidence)
Entrez Gene50781 (Evidence)
DFCITC1572024, TC1625937
DoTSDT.482145, DT.111004620, DT.94222140, DT.97332533
NIA Mouse Gene IndexU029133
Consensus CDS ProjectCCDS21752.1
International Mouse Knockout Project StatusDkk3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 50781 NCBI Gene Model | MGI Sequence Detail 43039 C57BL/6J ±  kb
transcript NM_015814 RefSeq | MGI Sequence Detail 3357 C57BL/6 
polypeptide Q9QUN9 UniProt | EBI | MGI Sequence Detail 349 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(473 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006796 Dickkopf, N-terminal cysteine-rich
Protein Ontology PR:000006501 dickkopf-related protein 3
Graphical View of Protein Domain Structure
References (Earliest) J:57798 Monaghan AP, et al., Dickkopf genes are co-ordinately expressed in mesodermal lineages. Mech Dev. 1999 Sep;87(1-2):45-56
(Latest) J:208217 Schmolka N, et al., Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory gammadelta T cell subsets. Nat Immunol. 2013 Oct;14(10):1093-100
All references(71)
Other
accession IDs
MGI:2142202, MGI:2142371

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory