About   Help   FAQ
Dkk3
Gene Detail
Symbol

Name
ID
Dkk3
dickkopf homolog 3 (Xenopus laevis)
MGI:1354952
Feature Type
protein coding gene
Genetic Map
Chromosome 7
58.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:112116019-112159057 bp, - strand
From Ensembl annotation of GRCm38

  43039 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8303  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: DKK3
Protein SuperFamily: Dickkopf-related protein 3 (Dkk-3)
Gene Tree: Dkk3

Human
homologs
DKK3, dickkopf WNT signaling pathway inhibitor 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 27122
neXtProt AC: NX_Q9UBP4

Human Synonyms: REIC, RIG

Human Chr (Location): 11p15.2; chr11:11962996-12009370 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele are viable, fertile and euthyroid but exhibit hyperactivity, a slight but significant decrease in the frequency of natural killer cells, and significantly increased IgM, hemoglobin, and hematocrit levels.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Dkk3 interacts with 253 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (37 records)
Data Summary: Results (529)    Tissues (338)    Images (148)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 491
RT-PCR 34
cDNA source data(12)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA DKK3 ; Xenbase dkk3 ; ZFIN dkk3a, dkk3b    NEW 
Molecular
reagents
All nucleic(26) cDNA(16) Primer pair(8) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000030772 (Evidence)
Entrez Gene 50781 (Evidence)
DFCI TC1625937, TC1572024
DoTS DT.482145, DT.111004620, DT.94222140, DT.97332533
NIA Mouse Gene Index U029133
Consensus CDS Project CCDS21752.1
International Mouse Phenotyping Consortium Status Dkk3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030772 Ensembl Gene Model | MGI Sequence Detail 43039 C57BL/6J ±  kb
transcript ENSMUST00000033036 Ensembl | MGI Sequence Detail 3357 Not Applicable 
polypeptide ENSMUSP00000033036 Ensembl | MGI Sequence Detail 349 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(473 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006796 Dickkopf, N-terminal cysteine-rich
Protein Ontology PR:000006501 dickkopf-related protein 3
References
(Earliest) J:57798 Monaghan AP, et al., Dickkopf genes are co-ordinately expressed in mesodermal lineages. Mech Dev. 1999 Sep;87(1-2):45-56
(Latest) J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
All references(73)
Other
accession IDs
MGI:2142202, MGI:2142371

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory