Nrbf2 MGI Mouse Gene Detail - MGI:1354950 - nuclear receptor binding factor 2

Symbol

Nrbf2
Name

nuclear receptor binding factor 2

Feature Type

protein coding gene
IDs

MGI:1354950
NCBI Gene: 641340
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr10:67102463-67121076 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 34.89 cM
Mapping Data

1 experiment

SNPs within 2kb

507 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354950	protein coding gene	Chr10:67102463-67121084 (-)
129S1/SvImJ	ENSMUSG00200016933	protein coding gene	Chr10:63798860-63817479 (-)
A/J	ENSMUSG00195005626	protein coding gene	Chr10:64093081-64111695 (-)
AKR/J	ENSMUSG00220026170	protein coding gene	Chr10:63761927-63780543 (-)
BALB/cJ	ENSMUSG00180007481	protein coding gene	Chr10:64127640-64146258 (-)
C3H/HeJ	ENSMUSG00175011632	protein coding gene	Chr10:63962171-63980787 (-)
C57BL/6NJ	ENSMUSG00215003414	protein coding gene	Chr10:63737157-63755777 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015408	protein coding gene	Chr10:61464090-61483705 (-)
CAST/EiJ	ENSTCUG00005024992	protein coding gene	Chr10:63695947-63714786 (-)
CBA/J	ENSMUSG00210009306	protein coding gene	Chr10:63842023-63860639 (-)
DBA/2J	ENSMUSG00185019102	protein coding gene	Chr10:64204843-64223459 (-)
FVB/NJ	ENSMUSG00205007259	protein coding gene	Chr10:63908644-63927224 (-)
JF1/MsJ	ENSUMUG00000015603	protein coding gene	Chr10:65402169-65421000 (-)
LP/J	ENSMUSG00230018078	protein coding gene	Chr10:65971181-65989760 (-)
NOD/ShiLtJ	ENSMUSG00190007923	protein coding gene	Chr10:64203032-64221611 (-)
NZO/HlLtJ	ENSMUSG00225044720	protein coding gene	Chr10:70259550-70278166 (-)
PWK/PhJ	ENSLUMG00010007629	protein coding gene	Chr10:63800374-63819194 (-)
SPRET/EiJ	ENSMSPG00010022142	protein coding gene	Chr10:65449082-65468275 (-)
WSB/EiJ	ENSIUOG00005032980	protein coding gene	Chr10:63729038-63747663 (-)

Human Ortholog

NRBF2, nuclear receptor binding factor 2

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NRBF2, nuclear receptor binding factor 2
Synonyms

COPR, COPR1, COPR2, NRBF-2
Links

HGNC:19692

NCBI Gene ID: 29982

UniProt: Q96F24
Chr Location

10q21.3; chr10:63133247-63155031 (+) GRCh38

MGI Vertebrate Homology

Nrbf2 stringent orthology
1 human;1 mouse;3 rat;2 zebrafish
HCOP

vertebrate homology predictions: NRBF2
Gene Tree

Nrbf2

less

Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

2
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Nrbf2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous null for this allele develop focal liver necrosis and ductular reaction in the liver and cells show impaired autophagosome maturation and increased susceptibility to ER stress.

less

All GO Annotations

26
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

37

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NRBF2

Xenbase nrbf2

ZFIN nrbf2b

less

All Sequences

52
RefSeq

8
UniProt

2
CCDS

CCDS23902.1

Ensembl

ENSMUSG00000075000 (Evidence)
NCBI Gene

641340

			Length	Strain/Species	Flank
genomic	641340	NCBI Gene Model \| MGI Sequence Detail	18614	C57BL/6J	± kb
transcript	NM_001402047	RefSeq \| MGI Sequence Detail	2972	C57BL/6
polypeptide	Q8VCQ3	UniProt \| EBI \| MGI Sequence Detail	287	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000011417 nuclear receptor-binding factor 2

(term hierarchy)
PDB

2CRB, 9WT3
InterPro Domains

IPR039679 Nuclear receptor-binding factor 2

IPR015056 Nuclear receptor-binding factor 2, C-terminal

IPR033393 Nuclear receptor-binding factor 2, MIT domain

less

All nucleic 37

cDNA 37

Microarray probesets 5

Summaries

All 51

Gene Ontology 12

Phenotypes 20
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:362945 Wu S, et al., NRBF2 plays a crucial role in the acquisition process of learning and memory, independent of the Vps34 complex. Front Behav Neurosci. 2025;19:1529522

TSS for Nrbf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97946	Chr10:67121027-67121095 (-)	15 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24