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Plpp2 Gene Detail
Summary
  • Symbol
    Plpp2
  • Name
    phospholipid phosphatase 2
  • Synonyms
    Lpp2, Ppap2c
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354945
    NCBI Gene: 50784
Location & Maps
more
  • Sequence Map
    Chr10:79526430-79533787 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7358 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PLPP2, phospholipid phosphatase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLPP2, phospholipid phosphatase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LPP2, PAP-2c, PAP2-g, PPAP2C
  • Links
    NCBI Gene ID: 8612
    neXtProt AC: NX_O43688

  • Chr Location
    19p13; chr19:281040-291435 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Plpp2
  • Incidental Mutations
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035138 VEGA Gene Model | MGI Sequence Detail 7358 C57BL/6J ±  kb
transcript OTTMUST00000089467 VEGA | MGI Sequence Detail 1645 Not Applicable  
polypeptide OTTMUSP00000048896 VEGA | MGI Sequence Detail 276 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    24 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013053 phospholipid phosphatase 2
  • EC
  • InterPro Domains
    IPR028674 Lipid phosphate phosphohydrolase 2
    IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
Molecular
Reagents
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  • All nucleic 147
    Genomic 1
    cDNA 145
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 28
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:60562 Zhang N, et al., Cloning, expression, and chromosomal localization of a mouse gene homologous to the germ cell migration regulator wunen and to type 2 phosphatidic acid phosphatases. Genomics. 2000 Jan 1;63(1):142-4
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory