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Crim1 Gene Detail
Summary
  • Symbol
    Crim1
  • Name
    cysteine rich transmembrane BMP regulator 1 (chordin like)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354756
    NCBI Gene: 50766
  • Gene Overview
    MyGene.info: CRIM1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:78200248-78376592 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      176345 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 48.09 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CRIM1, cysteine rich transmembrane BMP regulator 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CRIM1, cysteine rich transmembrane BMP regulator 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRIM-1, S52
  • Links
    NCBI Gene ID: 51232
    neXtProt AC: NX_Q9NZV1
    UniProt: Q9NZV1

  • Chr Location
    2p22.2; chr2:36356088-36551135 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    63 phenotypes from 4 alleles in 7 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this locus cause perinatal lethality, syndactyly, and eye and kidney abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024074 Ensembl Gene Model | MGI Sequence Detail 176345 C57BL/6J ±  kb
    transcript ENSMUST00000112498 Ensembl | MGI Sequence Detail 5995 Not Applicable  
    polypeptide ENSMUSP00000108117 Ensembl | MGI Sequence Detail 1037 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1585 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 55
      Primer pair 10

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146965
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 20
      Gene Ontology 3
      Phenotypes 15
    • Earliest
      J:60432 Kolle G, et al., CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. Mech Dev. 2000 Feb;90(2):181-93
    • Latest
      J:261316 Perez-Garcia V, et al., Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature. 2018 Mar 22;555(7697):463-468

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory