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Crim1 Gene Detail
Summary
  • Symbol
    Crim1
  • Name
    cysteine rich transmembrane BMP regulator 1 (chordin like)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354756
    NCBI Gene: 50766
  • Gene Overview
    MyGene.info: CRIM1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:78200248-78376592 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 48.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1585 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354756
protein coding gene Chr17:78200232-78376592 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024036
protein coding gene Chr17:81010013-81193220 (+)
A/J MGP_AJ_G0023993
protein coding gene Chr17:78529429-78706429 (+)
AKR/J MGP_AKRJ_G0023962
protein coding gene Chr17:79719675-79900718 (+)
BALB/cJ MGP_BALBcJ_G0023995
protein coding gene Chr17:78387488-78564566 (+)
C3H/HeJ MGP_C3HHeJ_G0023759
protein coding gene Chr17:80615718-80798468 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024440
protein coding gene Chr17:83956413-84145738 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021884
protein coding gene Chr17:73924941-74104691 (+)
CAST/EiJ MGP_CASTEiJ_G0023239
protein coding gene Chr17:81201471-81381387 (+)
CBA/J MGP_CBAJ_G0023733
protein coding gene Chr17:87496677-87682757 (+)
DBA/2J MGP_DBA2J_G0023862
protein coding gene Chr17:77052465-77230662 (+)
FVB/NJ MGP_FVBNJ_G0023828
protein coding gene Chr17:76571204-76749622 (+)
LP/J MGP_LPJ_G0023945
protein coding gene Chr17:81860360-82041951 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023856
protein coding gene Chr17:87612449-87795090 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024484
protein coding gene Chr17:80177240-80360925 (+)
PWK/PhJ MGP_PWKPhJ_G0022985
protein coding gene Chr17:76527051-76706932 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022796
protein coding gene Chr17:76963618-77146677 (+)
WSB/EiJ MGP_WSBEiJ_G0023306
protein coding gene Chr17:80994958-81175601 (+)



Homology
more
  • Human Ortholog
    CRIM1, cysteine rich transmembrane BMP regulator 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CRIM1, cysteine rich transmembrane BMP regulator 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRIM-1, S52
  • Links
    NCBI Gene ID: 51232
    neXtProt AC: NX_Q9NZV1
    UniProt: Q9NZV1

  • Chr Location
    2p22.2; chr2:36356088-36551135 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    96 phenotypes from 5 alleles in 8 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this locus cause perinatal lethality, syndactyly, and eye and kidney abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024074 Ensembl Gene Model | MGI Sequence Detail 176345 C57BL/6J ±  kb
    transcript ENSMUST00000112498 Ensembl | MGI Sequence Detail 5995 Not Applicable  
    polypeptide ENSMUSP00000108117 Ensembl | MGI Sequence Detail 1037 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 57
      Primer pair 11

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146965
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 20
      Gene Ontology 3
      Phenotypes 17
    • Earliest
      J:60432 Kolle G, et al., CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. Mech Dev. 2000 Feb;90(2):181-93
    • Latest
      J:261316 Perez-Garcia V, et al., Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature. 2018 Mar 22;555(7697):463-468

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory