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Crim1 Gene Detail
Summary
  • Symbol
    Crim1
  • Name
    cysteine rich transmembrane BMP regulator 1 (chordin like)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354756
    NCBI Gene: 50766
  • Gene Overview
    MyGene.info: CRIM1
Location & Maps
more
  • Sequence Map
    Chr17:78200248-78376592 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      176345 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CRIM1, cysteine rich transmembrane BMP regulator 1 (chordin-like)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CRIM1, cysteine rich transmembrane BMP regulator 1 (chordin-like)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CRIM-1, S52
  • Links
    NCBI Gene ID: 51232
    neXtProt AC: NX_Q9NZV1

  • Chr Location
    2p21; chr2:36355771-36551135 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    63 phenotypes from 4 alleles in 7 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mutations in this locus cause perinatal lethality, syndactyly, and eye and kidney abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024074 Ensembl Gene Model | MGI Sequence Detail 176345 C57BL/6J ±  kb
transcript ENSMUST00000112498 Ensembl | MGI Sequence Detail 5995 Not Applicable  
polypeptide ENSMUSP00000108117 Ensembl | MGI Sequence Detail 1037 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1585 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005871 cysteine-rich motor neuron 1 protein
  • InterPro Domains
    IPR004094 Antistasin-like domain
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR011061 Hirudin/antistatin
    IPR000867 Insulin-like growth factor-binding protein, IGFBP
    IPR001007 VWFC domain
Molecular
Reagents
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  • All nucleic 65
    cDNA 55
    Primer pair 10

    Microarray probesets 4
Other
Accession IDs
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MGI:2146965
References
more
  • Summaries
    All 50
    Developmental Gene Expression 18
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:60432 Kolle G, et al., CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. Mech Dev. 2000 Feb;90(2):181-93
  • Latest
    J:220878 Beleggia F, et al., CRIM1 haploinsufficiency causes defects in eye development in human and mouse. Hum Mol Genet. 2015 Apr 15;24(8):2267-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory