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Crim1
Gene Detail
Symbol

Name
ID
Crim1
cysteine rich transmembrane BMP regulator 1 (chordin like)
MGI:1354756
Feature Type
protein coding gene
Genetic Map
Chromosome 17
48.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:78200248-78376592 bp, + strand
From Ensembl annotation of GRCm38

  176345 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9510  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CRIM1
Gene Tree: Crim1

Human
homologs
CRIM1, cysteine rich transmembrane BMP regulator 1 (chordin-like)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 51232
neXtProt AC: NX_Q9NZV1

Human Synonyms: CRIM-1, S52

Human Chr (Location): 2p21; chr2:36355771-36551135 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutations in this locus cause perinatal lethality, syndactyly, and eye and kidney abnormalities.
 
Interactions
Crim1 interacts with 422 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process regulation of cell growth
Component extracellular exosome, extracellular region, ...
Function enzyme inhibitor activity, insulin-like growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (308)    Tissues (191)    Images (104)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 194
In situ reporter (knock in) 65
Northern blot 6
Western blot 3
RT-PCR 40
cDNA source data(55)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100488895 ; ZFIN crim1    NEW 
Molecular
reagents
All nucleic(65) cDNA(55) Primer pair(10)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000024074 (Evidence)
Entrez Gene 50766 (Evidence)
UniGene 311912
DFCI TC1583769, TC1704594
DoTS DT.484706, DT.102550336
NIA Mouse Gene Index U018233
Consensus CDS Project CCDS28976.1
International Mouse Phenotyping Consortium Status Crim1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024074 Ensembl Gene Model | MGI Sequence Detail 176345 C57BL/6J ±  kb
transcript ENSMUST00000112498 Ensembl | MGI Sequence Detail 5995 Not Applicable 
polypeptide ENSMUSP00000108117 Ensembl | MGI Sequence Detail 1037 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(1589 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000867 Insulin-like growth factor-binding protein, IGFBP
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR011061 Proteinase inhibitor I14/I15, hirudin/antistatin
InterPro IPR004094 Proteinase inhibitor I15, antistasin-like
InterPro IPR001007 von Willebrand factor, type C
Protein Ontology PR:000005871 cysteine-rich motor neuron 1 protein
References
(Earliest) J:60432 Kolle G, et al., CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. Mech Dev. 2000 Feb;90(2):181-93
(Latest) J:220878 Beleggia F, et al., CRIM1 haploinsufficiency causes defects in eye development in human and mouse. Hum Mol Genet. 2015 Apr 15;24(8):2267-73
All references(53)
Other
accession IDs
MGI:2146965

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory