Crim1
Gene Detail

Symbol Name ID

Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) MGI:1354756

Feature Type

protein coding gene

Genetic Map

Chromosome 17

48.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:78200248-78376592 bp, + strand From NCBI annotation of GRCm38   176345 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9510  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Crim1

Human homologs

Human Homolog		CRIM1, cysteine rich transmembrane BMP regulator 1 (chordin-like)
NCBI Gene ID		51232
neXtProt AC		NX_Q9NZV1
Human Synonyms		CRIM-1, S52
Human Chr (Location)		2p21; chr2:36583370-36778278 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Mutations in this locus cause perinatal lethality, syndactyly, and eye and kidney abnormalities.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	regulation of cell growth
Component	extracellular region, integral to membrane, ...
Function	enzyme inhibitor activity, insulin-like growth factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (163)    Tissues (98)    Images (53)
Theiler Stages: 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	157
Northern blot	6

cDNA source data(55)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(55) cDNA(55)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000024074 (Evidence)
Entrez Gene	50766 (Evidence)
UniGene	311912
DFCI	TC1583769, TC1704594
DoTS	DT.102550336, DT.484706
NIA Mouse Gene Index	U018233
Consensus CDS Project	CCDS28976.1
International Mouse Knockout Project Status	Crim1

Sequences

Length	Strain/Species
genomic	50766	NCBI Gene Model | MGI Sequence Detail	176345	C57BL/6J
transcript	NM_015800	RefSeq | MGI Sequence Detail	5995	C57BL/6
polypeptide	Q9JLL0	UniProt | EBI | MGI Sequence Detail	1037	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(399 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000867	Insulin-like growth factor-binding protein, IGFBP
InterPro	IPR011061	Proteinase inhibitor I14/I15, hirudin/antistatin
InterPro	IPR018112	Proteinase inhibitor I15, antistasin
InterPro	IPR004094	Proteinase inhibitor I15, antistasin-like
InterPro	IPR001007	von Willebrand factor, type C
Protein Ontology	PR:000005871	cysteine-rich motor neuron 1 protein

Graphical View of Protein Domain Structure

References

(Earliest) J:60432 Kolle G, et al., CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. Mech Dev. 2000 Feb;90(2):181-93
(Latest) J:194415 Phua YL, et al., Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins. J Pathol. 2013 Apr;229(5):685-96
All references(51)

Other accession IDs

MGI:2146965