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Fbxo6 Gene Detail
Summary
  • Symbol
    Fbxo6
  • Name
    F-box protein 6
  • Synonyms
    FBG2, Fbs2, Fbx6b, Fbxo6b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354743
    NCBI Gene: 50762
  • Gene Overview
    MyGene.info: FBXO6
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:148145716-148152135 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 78.67 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354743
protein coding gene Chr4:148145716-148152140 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029119
protein coding gene Chr4:151835647-151842130 (-)
A/J MGP_AJ_G0029084
protein coding gene Chr4:145564782-145571202 (-)
AKR/J MGP_AKRJ_G0029032
protein coding gene Chr4:149531495-149537929 (-)
BALB/cJ MGP_BALBcJ_G0029100
protein coding gene Chr4:146074765-146081214 (-)
C3H/HeJ MGP_C3HHeJ_G0028821
protein coding gene Chr4:150088803-150095229 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029549
protein coding gene Chr4:157375703-157382165 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026795
protein coding gene Chr4:137987814-137994926 (-)
CAST/EiJ MGP_CASTEiJ_G0028234
protein coding gene Chr4:147283103-147292777 (-)
CBA/J MGP_CBAJ_G0028783
protein coding gene Chr4:161902904-161913523 (-)
DBA/2J MGP_DBA2J_G0028931
protein coding gene Chr4:145672890-145679286 (-)
FVB/NJ MGP_FVBNJ_G0028896
protein coding gene Chr4:144762508-144769874 (-)
LP/J MGP_LPJ_G0029022
protein coding gene Chr4:151802262-151808756 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028923
protein coding gene Chr4:165269675-165276082 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029581
protein coding gene Chr4:150011150-150017643 (-)
PWK/PhJ MGP_PWKPhJ_G0027954
protein coding gene Chr4:141658969-141665571 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027788
protein coding gene Chr4:144273634-144281864 (-)
WSB/EiJ MGP_WSBEiJ_G0028314
protein coding gene Chr4:150167556-150176562 (-)



Homology
more
  • Human Ortholog
    FBXO6, F-box protein 6
  • Vertebrate Orthologs
    17
  • Human Ortholog
    FBXO6, F-box protein 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FBG2, FBS2, FBX6, Fbx6b
  • Links
    NCBI Gene ID: 26270
    neXtProt AC: NX_Q9NRD1
    UniProt: Q9NRD1

  • Chr Location
    1p36.22; chr1:11664093-11674354 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9274
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;8 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FBXO6
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 50762 NCBI Gene Model | MGI Sequence Detail 6420 C57BL/6J ±  kb
transcript NM_015797 RefSeq | MGI Sequence Detail 1955 C57BL/6  
polypeptide Q9QZN4 UniProt | EBI | MGI Sequence Detail 295 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 74
    cDNA 74

    Microarray probesets 5
Other
Accession IDs
less
MGI:2140136
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
  • Latest
    J:222147 Groisman B, et al., Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps. J Biol Chem. 2011 Jan 14;286(2):1292-300

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory