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Fbxo6 Gene Detail
Summary
  • Symbol
    Fbxo6
  • Name
    F-box protein 6
  • Synonyms
    FBG2, Fbs2, Fbx6b, Fbxo6b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354743
    NCBI Gene: 50762
  • Gene Overview
    MyGene.info: FBXO6
Location & Maps
more
  • Sequence Map
    Chr4:148145716-148152140 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6425 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 78.67 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FBXO6, F-box protein 6
  • Vertebrate Orthologs
    17
  • Human Ortholog
    FBXO6, F-box protein 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FBG2, FBS2, FBX6, Fbx6b
  • Links
    NCBI Gene ID: 26270
    neXtProt AC: NX_Q9NRD1

  • Chr Location
    1p36.22; chr1:11664093-11674354 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9274
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;8 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: FBXO6
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    66
  • Chemically induced (other)
    1
  • Gene trapped
    62
  • Targeted
    3
  • Genomic Mutations
    2 involving Fbxo6
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010945 VEGA Gene Model | MGI Sequence Detail 6425 C57BL/6J ±  kb
transcript OTTMUST00000070120 VEGA | MGI Sequence Detail 1938 Not Applicable  
polypeptide OTTMUSP00000035702 VEGA | MGI Sequence Detail 295 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    114 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 73
    cDNA 73

    Microarray probesets 5
Other
Accession IDs
less
MGI:2140136
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
  • Latest
    J:222147 Groisman B, et al., Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps. J Biol Chem. 2011 Jan 14;286(2):1292-300

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory