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Fbxo6
Gene Detail
Symbol

Name
ID
Fbxo6
F-box protein 6
MGI:1354743
Synonyms
FBG2, Fbs2, Fbx6b, Fbxo6b
Feature Type
protein coding gene
Genetic Map
Chromosome 4
78.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:148145716-148152140 bp, - strand
From VEGA annotation of GRCm38

  6425 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9274  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 8 zebrafish

HCOP human homology predictions: FBXO6
Gene Tree: Fbxo6

Human
homologs
FBXO6, F-box protein 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 26270
neXtProt AC: NX_Q9NRD1

Human Synonyms: FBG2, FBS2, FBX6, Fbx6b

Human Chr (Location): 1p36.22; chr1:11664093-11674354 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(65) : Gene trapped(62) Targeted(3)
Genomic Mutations involving Fbxo6 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Fbxo6 interacts with 37 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component cytoplasm, endoplasmic reticulum quality control compartment, ...
Function carbohydrate binding, glycoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (17)    Tissues (14)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 17
cDNA source data(73)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(73) cDNA(73)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000010945 (Evidence)
Ensembl Gene Model ENSMUSG00000055401 (Evidence)
Entrez Gene 50762 (Evidence)
UniGene 27445
DFCI TC1577174, TC1643549, TC1688276, TC1749968
DoTS DT.101373636, DT.534686, DT.94122572, DT.97372417, DT.97372419, DT.97372420
NIA Mouse Gene Index U025786
Consensus CDS Project CCDS18933.1
International Mouse Phenotyping Consortium Status Fbxo6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010945 VEGA Gene Model | MGI Sequence Detail 6425 C57BL/6J ±  kb
transcript OTTMUST00000025666 VEGA | MGI Sequence Detail 1346 Not Applicable 
polypeptide OTTMUSP00000011764 VEGA | MGI Sequence Detail 295 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(12) UniProt(5)
Polymorphisms
SNPs within 2kb(114 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007397 F-box associated (FBA) domain
InterPro IPR001810 F-box domain, cyclin-like
InterPro IPR008979 Galactose-binding domain-like
Protein Ontology PR:000007418 F-box only protein 6
References
(Earliest) J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
(Latest) J:222147 Groisman B, et al., Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps. J Biol Chem. 2011 Jan 14;286(2):1292-300
All references(33)
Other
accession IDs
MGI:2140136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory