Synrg MGI Mouse Gene Detail - MGI:1354742

Symbol

Synrg
Name

synergin, gamma
Synonyms

Ap1gbp1, L71-5

Feature Type

protein coding gene
IDs

MGI:1354742
NCBI Gene: 217030
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:83855254-83935404 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 51.25 cM
Mapping Data

1 experiment

SNPs within 2kb

341 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354742	protein coding gene	Chr11:83855217-83935404 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018864	protein coding gene	Chr11:85356557-85441031 (+)
A/J	MGP_AJ_G0018831	protein coding gene	Chr11:82115511-82196107 (+)
AKR/J	MGP_AKRJ_G0018801	protein coding gene	Chr11:84536672-84616425 (+)
BALB/cJ	MGP_BALBcJ_G0018804	protein coding gene	Chr11:82497839-82580893 (+)
C3H/HeJ	MGP_C3HHeJ_G0018618	protein coding gene	Chr11:84589441-84670593 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019256	protein coding gene	Chr11:87944283-88028162 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016889	protein coding gene	Chr11:79205077-79287637 (+)
CAST/EiJ	MGP_CASTEiJ_G0018173	protein coding gene	Chr11:85220041-85306378 (+)
CBA/J	MGP_CBAJ_G0018589	protein coding gene	Chr11:91722202-91805782 (+)
DBA/2J	MGP_DBA2J_G0018697	protein coding gene	Chr11:81692627-81773587 (+)
FVB/NJ	MGP_FVBNJ_G0018686	protein coding gene	Chr11:81162758-81244853 (+)
LP/J	MGP_LPJ_G0018767	protein coding gene	Chr11:85893354-85974680 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018713	protein coding gene	Chr11:91867275-91952025 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019296	protein coding gene	Chr11:84818994-84899791 (+)
PWK/PhJ	MGP_PWKPhJ_G0017942	protein coding gene	Chr11:82446915-82528129 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017734	protein coding gene	Chr11:84349290-84437494 (+)
WSB/EiJ	MGP_WSBEiJ_G0018224	protein coding gene	Chr11:84661588-84744052 (+)

Human Ortholog

SYNRG, synergin gamma

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SYNRG, synergin gamma
Synonyms

AP1GBP1, SYNG
Links

HGNC:557

NCBI Gene ID: 11276

neXtProt AC: NX_Q9UMZ2

UniProt: Q9UMZ2
Chr Location

17q12; chr17:37514807-37609472 (-) GRCh38

MGI Vertebrate Homology

Synrg stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SYNRG
Gene Tree

Synrg

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

53
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

47
Targeted

4
Genomic Mutations

3 involving Synrg
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

67 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

757
Tissues

39
cDNA Data

12
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase synrg

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All Sequences

88
RefSeq

32
UniProt

5
CCDS

CCDS25181.1, CCDS48870.1

Ensembl

ENSMUSG00000034940 (Evidence)
NCBI Gene

217030

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034940	Ensembl Gene Model \| MGI Sequence Detail	80151	C57BL/6J	± kb
transcript	ENSMUST00000183456	Ensembl \| MGI Sequence Detail	3990	Not Applicable
polypeptide	ENSMUSP00000138969	Ensembl \| MGI Sequence Detail	1329	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004093 synergin gamma

(term hierarchy)
InterPro Domains

IPR011992 EF-hand domain pair

IPR000261 EH domain

IPR039656 Synergin gamma

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All nucleic 13

Genomic 1

cDNA 12

Microarray probesets 6

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MGI:2144616

Summaries

All 47

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 18
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:334297 Warren EB, et al., 17q12 deletion syndrome mouse model shows defects in craniofacial, brain and kidney development, and glucose homeostasis. Dis Model Mech. 2022 Dec 1;15(12):dmm049752

TSS for Synrg:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103784	Chr11:83855195-83855216 (+)	-48 bp
Tssr103785	Chr11:83855245-83855304 (+)	21 bp
Tssr103786	Chr11:83923858-83923864 (+)	68,607 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23