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Sh3bgr Gene Detail
Summary
  • Symbol
    Sh3bgr
  • Name
    SH3-binding domain glutamic acid-rich protein
  • Synonyms
    5430437A18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354740
    NCBI Gene: 50795
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:96001670-96030133 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 56.86 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    386 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354740
 protein coding gene Chr16:96001650-96030135 (+)
129S1/SvImJ ENSMUSG00200016465
 protein coding gene Chr16:92934059-92963025 (+)
A/J ENSMUSG00195016170
 protein coding gene Chr16:92692438-92721414 (+)
AKR/J ENSMUSG00220009251
 protein coding gene Chr16:92941767-92970743 (+)
BALB/cJ ENSMUSG00180001205
 protein coding gene Chr16:92766567-92795545 (+)
C3H/HeJ ENSMUSG00175002826
 protein coding gene Chr16:93103357-93132334 (+)
C57BL/6NJ ENSMUSG00215014666
 protein coding gene Chr16:92908052-92937032 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021002
 protein coding gene Chr16:90800537-90826756 (+)
CAST/EiJ ENSTCUG00005012667
 protein coding gene Chr16:92488564-92516717 (+)
CBA/J ENSMUSG00210017736
 protein coding gene Chr16:93006647-93035647 (+)
DBA/2J ENSMUSG00185003544
 protein coding gene Chr16:92950261-92979237 (+)
FVB/NJ ENSMUSG00205015330
 protein coding gene Chr16:92725308-92754258 (+)
JF1/MsJ ENSUMUG00000014043
 protein coding gene Chr16:93069520-93098488 (+)
LP/J ENSMUSG00230027812
 protein coding gene Chr16:95480543-95509511 (+)
NOD/ShiLtJ ENSMUSG00190003861
 protein coding gene Chr16:92912670-92941688 (+)
NZO/HlLtJ ENSMUSG00225030748
 protein coding gene Chr16:98584945-98613949 (+)
PWK/PhJ ENSLUMG00010014510
 protein coding gene Chr16:92724388-92753383 (+)
SPRET/EiJ ENSMSPG00010020640
 protein coding gene Chr16:93833165-93861208 (+)
WSB/EiJ ENSIUOG00005013935
 protein coding gene Chr16:92847294-92876218 (+)



Homology
more
  • Human Ortholog
    SH3BGR, SH3 domain binding glutamate rich protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SH3BGR, SH3 domain binding glutamate rich protein
  • Synonyms
    21-GARP
  • Links
    NCBI Gene ID: 6450
    UniProt: P55822

  • Chr Location
    21q22.2; chr21:39445855-39515506 (+)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    94 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    860
  • Tissues
    227
  • cDNA Data
    29
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 50795 NCBI Gene Model | MGI Sequence Detail 28464 C57BL/6J ±  kb
transcript NM_015825 RefSeq | MGI Sequence Detail 1321 Not Specified  
polypeptide Q9WUZ7 UniProt | EBI | MGI Sequence Detail 214 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000032716 SH3 domain-binding glutamic acid-rich protein
    (term hierarchy)
  • InterPro Domains
    IPR006993 SH3-binding, glutamic acid-rich protein
    IPR051033 SH3 domain-binding glutamic acid-rich protein
    IPR036249 Thioredoxin-like superfamily
  • GlyGen
    Q9WUZ7 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 33
    cDNA 30
    Primer pair 2
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1918665
References
more
  • Summaries
    All 124
    Developmental Gene Expression 6
    Diseases 6
    Gene Ontology 2
    Phenotypes 94
  • Earliest
    J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
  • Latest
    J:385727 Harada K, et al., Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome. Immunology. 2026 Mar;177(3):596-612
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory