Rgs11
Gene Detail

Symbol Name ID

Rgs11 regulator of G-protein signaling 11 MGI:1354739

Feature Type

protein coding gene

Genetic Map

Chromosome 17

13.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:26202951-26211319 bp, + strand From VEGA annotation of GRCm38   8369 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:77719  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: regulator of G protein signaling, RGS7 type
Gene Tree: Rgs11

Human homologs

Human Homolog		RGS11, regulator of G-protein signaling 11
NCBI Gene ID		8786
neXtProt AC		NX_O94810
Human Synonyms		RS11
Human Chr (Location)		16p13.3; chr16:318310-325914 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a null allele exhibit abnormal cone and rod b-wave electrophysiology.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	G-protein coupled receptor signaling pathway, intracellular signal transduction, ...
Component	cytoplasm, dendrite terminus, ...
Function	GTPase activator activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (112)    Tissues (27)    Images (24)
Theiler Stages: 19, 21, 22, 23, 26, 28

Assay Type	Results
RNA in situ	106
RT-PCR	6

cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(45) cDNA(43) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000026502 (Evidence)
Ensembl Gene Model	ENSMUSG00000024186 (Evidence)
Entrez Gene	50782 (Evidence)
UniGene	109840
DFCI	TC1581933, TC1602584, TC1613950, TC1621623, TC1624376, TC1651144
DoTS	DT.101234081, DT.101382313, DT.484819, DT.87030943, DT.94189124
NIA Mouse Gene Index	U017702
Consensus CDS Project	CCDS37511.1
International Mouse Knockout Project Status	Rgs11

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026502	VEGA Gene Model | MGI Sequence Detail	8369	C57BL/6J
transcript	OTTMUST00000065541	VEGA | MGI Sequence Detail	2005	Not Applicable
polypeptide	OTTMUSP00000032677	VEGA | MGI Sequence Detail	464	Not Applicable

All sequences(59) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(10 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000591	DEP domain
InterPro	IPR015898	G-protein gamma-like domain
InterPro	IPR024066	Regulator of G-protein signaling, domain 1
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000013946	regulator of G-protein signaling 11

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:185272 Orlandi C, et al., GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes. J Cell Biol. 2012 Jun 11;197(6):711-9
All references(48)

Other accession IDs

MGI:2147122