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Rgs11
Gene Detail
Symbol

Name
ID
Rgs11
regulator of G-protein signaling 11
MGI:1354739
Feature Type
protein coding gene
Genetic Map
Chromosome 17
13.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:26202951-26211319 bp, + strand
From VEGA annotation of GRCm38

  8369 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:77719  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RGS11
Protein SuperFamily: regulator of G protein signaling, RGS7 type
Gene Tree: Rgs11

Human
homologs
RGS11, regulator of G-protein signaling 11
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8786
neXtProt AC: NX_O94810

Human Synonyms: RS11

Human Chr (Location): 16p13.3; chr16:268301-275943 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Radiation induced(2) Targeted(2)
Genomic Mutations involving Rgs11 (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit abnormal cone and rod b-wave electrophysiology.
 
Phenotype Images(1)
Interactions
Rgs11 interacts with 85 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process G-protein coupled receptor signaling pathway, intracellular signal transduction, ...
Component cytoplasm, dendrite terminus, ...
Function G-protein beta-subunit binding, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (119)    Tissues (34)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 113
RT-PCR 6
cDNA source data(44)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) cDNA(44) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000026502 (Evidence)
Ensembl Gene Model ENSMUSG00000024186 (Evidence)
Entrez Gene 50782 (Evidence)
UniGene 109840
DFCI TC1624376, TC1621623, TC1613950, TC1602584, TC1581933, TC1651144
DoTS DT.484819, DT.101234081, DT.101382313, DT.87030943, DT.94189124
NIA Mouse Gene Index U017702
Consensus CDS Project CCDS37511.1
International Mouse Phenotyping Consortium Status Rgs11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026502 VEGA Gene Model | MGI Sequence Detail 8369 C57BL/6J ±  kb
transcript OTTMUST00000065541 VEGA | MGI Sequence Detail 2005 Not Applicable 
polypeptide OTTMUSP00000032677 VEGA | MGI Sequence Detail 464 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(93 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000591 DEP domain
InterPro IPR015898 G-protein gamma-like domain
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR016137 Regulator of G protein signalling superfamily
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000013946 regulator of G-protein signaling 11
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:221107 Sarria I, et al., Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior. Elife. 2015;4
All references(50)
Other
accession IDs
MGI:2147122

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory