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Kdm2a Gene Detail
Summary
  • Symbol
    Kdm2a
  • Name
    lysine (K)-specific demethylase 2A
  • Synonyms
    5530401A10Rik, Cxxc8, Fbl7, Fbxl11, Gm4560, Jhdm1a, lalina
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354736
    NCBI Gene: 225876
  • Gene Overview
    MyGene.info: KDM2A
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4316144-4398596 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.01 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    307 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354736
protein coding gene Chr19:4314419-4398596 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024662
protein coding gene Chr19:1176123-1263719 (-)
A/J MGP_AJ_G0024628
protein coding gene Chr19:1119570-1202978 (-)
AKR/J MGP_AKRJ_G0024601
protein coding gene Chr19:1146624-1239101 (-)
BALB/cJ MGP_BALBcJ_G0024628
protein coding gene Chr19:1109228-1193656 (-)
C3H/HeJ MGP_C3HHeJ_G0024396
protein coding gene Chr19:1152176-1238492 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025076
protein coding gene Chr19:1218090-1315057 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022505
protein coding gene Chr19:1056558-1141719 (-)
CAST/EiJ MGP_CASTEiJ_G0023868
protein coding gene Chr19:1159500-1250185 (-)
CBA/J MGP_CBAJ_G0024367
protein coding gene Chr19:1282536-1378524 (-)
DBA/2J MGP_DBA2J_G0024495
protein coding gene Chr19:1079351-1163533 (-)
FVB/NJ MGP_FVBNJ_G0024462
protein coding gene Chr19:1093495-1188121 (-)
LP/J MGP_LPJ_G0024581
protein coding gene Chr19:1183908-1276587 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024492
protein coding gene Chr19:1214229-1304539 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025123
protein coding gene Chr19:1152459-1240297 (-)
PWK/PhJ MGP_PWKPhJ_G0023614
protein coding gene Chr19:1134061-1220438 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023419
protein coding gene Chr19:1131491-1226677 (-)
WSB/EiJ MGP_WSBEiJ_G0023930
protein coding gene Chr19:1142285-1233678 (-)



Homology
more
  • Human Ortholog
    KDM2A, lysine demethylase 2A
  • Vertebrate Orthologs
    11
  • Human Ortholog
    KDM2A, lysine demethylase 2A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA
  • Links
    NCBI Gene ID: 22992
    neXtProt AC: NX_Q9Y2K7
    UniProt: Q9Y2K7

  • Chr Location
    11q13.2; chr11:67119210-67258082 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56564
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KDM2A
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show embryonic lethality, severe growth retardation, reduced neuron proliferation, increased neuron apoptosis, impaired neuron differentiation, small hearts, abnormal cardiac looping and, in some cases, incomplete embryonic turning and neural tube closure defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 225876 NCBI Gene Model | MGI Sequence Detail 82453 C57BL/6J ±  kb
    transcript NM_001001984 RefSeq | MGI Sequence Detail 7268 C57BL/6  
    polypeptide P59997 UniProt | EBI | MGI Sequence Detail 1161 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1918681, MGI:2147454, MGI:2147738, MGI:3782744
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
    • Latest
      J:236600 Dahl JA, et al., Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature. 2016 Sep 14;537(7621):548-552

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory