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Rgs3
Gene Detail
Symbol

Name
ID
Rgs3
regulator of G-protein signaling 3
MGI:1354734
Synonyms
4930506N09Rik, C2pa, C2PA-RGS3, PDZ-RGS3, RGS3S
Feature Type
protein coding gene
Genetic Map
Chromosome 4
33.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:62559847-62704001 bp, + strand
From VEGA annotation of GRCm38

  144155 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32440  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs3

Human
homologs
Human Homolog RGS3, regulator of G-protein signaling 3
NCBI Gene ID 5998
neXtProt AC  NX_P49796
Human Synonyms  C2PA, RGP3
Human Chr (Location)  9q32; chr9:113444729-113597743 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit impaired T cell migration in model of Th2-mediated airway inflammation.
 
Interactions
Rgs3 interacts with 321 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process G-protein coupled receptor signaling pathway, negative regulation of signal transduction, ...
Component cytoplasm, membrane, ...
Function GTPase activator activity
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (76)    Tissues (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
Northern blot 14
RT-PCR 59
cDNA source data(83)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(92) cDNA(85) Primer pair(6) Other(1)
Microarray probesets(8)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000313 VEGA Gene Model | MGI Sequence Detail 144155 C57BL/6J ±  kb
transcript OTTMUST00000000803 VEGA | MGI Sequence Detail 3888 Not Applicable 
polypeptide OTTMUSP00000000364 VEGA | MGI Sequence Detail 966 Not Applicable 

For the selected sequences
All sequences(156) RefSeq(44) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(903 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR001478 PDZ domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
Protein Ontology PR:000013958 regulator of G-protein signaling 3
References
(Earliest) J:64314 Linares JL, et al., C2PA, a new protein expressed during mouse spermatogenesis. FEBS Lett. 2000 Sep 1;480(2-3):249-54
(Latest) J:210195 Williams JW, et al., RGS3 controls T lymphocyte migration in a model of Th2-mediated airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15;305(10):L693-701
All references(42)
Other
accession IDs
MGI:1889637, MGI:1921949

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory