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Rgs3
Gene Detail
 Symbol
Name
ID
Rgs3
regulator of G-protein signaling 3
MGI:1354734
Synonyms 4930506N09Rik, C2pa, C2PA-RGS3, PDZ-RGS3, RGS3S
Feature Type protein coding gene
Genetic Map
Chromosome 4
33.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:62559847-62704001 bp, + strand
From VEGA annotation of GRCm38

  144155 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32440  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs3

Human
homologs
Human Homolog RGS3, regulator of G-protein signaling 3
NCBI Gene ID 5998
neXtProt AC  NX_P49796
Human Synonyms  C2PA, RGP3
Human Chr (Location)  9q32; chr9:113444729-113597743 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process G-protein coupled receptor signaling pathway, negative regulation of signal transduction, ...
Component cytoplasm, membrane, ...
Function GTPase activator activity
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (76)    Tissues (23)   
Theiler Stages: 17, 20, 25, 28
Assay TypeResults
RNA in situ 3
Northern blot 14
RT-PCR 59
cDNA source data(83)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(92) cDNA(85) Primer pair(6) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000000313 (Evidence)
Ensembl Gene ModelENSMUSG00000059810 (Evidence)
Entrez Gene50780 (Evidence)
UniGene286753
DFCITC1576587, TC1582811, TC1584443, TC1593362, TC1622800, TC1628191, TC1640976
DoTSDT.101172375, DT.101365936, DT.101403791, DT.101403792, DT.101724813, DT.103550092, DT.40172996, DT.534321, DT.91328471, DT.91341132, DT.91389114, DT.91580619, DT.94345405
NIA Mouse Gene IndexU004396, U069109
PDB1WHD
Consensus CDS ProjectCCDS18246.1, CCDS38776.1, CCDS51202.1
International Mouse Knockout Project StatusRgs3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000313 VEGA Gene Model | MGI Sequence Detail 144155 C57BL/6J ±  kb
transcript OTTMUST00000000803 VEGA | MGI Sequence Detail 3888 Not Applicable 
polypeptide OTTMUSP00000000364 VEGA | MGI Sequence Detail 966 Not Applicable 

For the selected sequences
All sequences(156) RefSeq(44) UniProt(9)
Polymorphisms RFLP(1) : SNPs within 2kb(903 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR001478 PDZ domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
Protein Ontology PR:000013958 regulator of G-protein signaling 3
References (Earliest) J:64314 Linares JL, et al., C2PA, a new protein expressed during mouse spermatogenesis. FEBS Lett. 2000 Sep 1;480(2-3):249-54
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)
Other
accession IDs
MGI:1889637, MGI:1921949

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory