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Rgs3
Gene Detail
Symbol

Name
ID
Rgs3
regulator of G-protein signaling 3
MGI:1354734
Synonyms
4930506N09Rik, C2pa, C2PA-RGS3, PDZ-RGS3, RGS3S
Feature Type
protein coding gene
Genetic Map
Chromosome 4
33.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:62559847-62704001 bp, + strand
From VEGA annotation of GRCm38

  144155 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32440  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

HCOP human homology predictions: RGS3
Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs3

Human
homologs
RGS3, regulator of G-protein signaling 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5998
neXtProt AC: NX_P49796

Human Synonyms: C2PA, RGP3

Human Chr (Location): 9q32; chr9:113444729-113597743 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted allele exhibit impaired T cell migration in model of Th2-mediated airway inflammation.
 
Interactions
Rgs3 interacts with 320 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process G-protein coupled receptor signaling pathway, negative regulation of signal transduction, ...
Component cytoplasm, membrane, ...
Function GTPase activator activity
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (76)    Tissues (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
Northern blot 14
RT-PCR 59
cDNA source data(83)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100486204 ; ZFIN rgs3a, rgs3b    NEW 
Molecular
reagents
All nucleic(92) cDNA(85) Primer pair(6) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000000313 (Evidence)
Ensembl Gene Model ENSMUSG00000059810 (Evidence)
Entrez Gene 50780 (Evidence)
UniGene 286753
DFCI TC1576587, TC1582811, TC1584443, TC1593362, TC1622800, TC1628191, TC1640976
DoTS DT.101172375, DT.101365936, DT.101403791, DT.101403792, DT.101724813, DT.103550092, DT.40172996, DT.534321, DT.91328471, DT.91341132, DT.91389114, DT.91580619, DT.94345405
NIA Mouse Gene Index U004396, U069109
PDB 1WHD
Consensus CDS Project CCDS18246.1, CCDS38776.1, CCDS51202.1, CCDS80110.1
International Mouse Phenotyping Consortium Status Rgs3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000313 VEGA Gene Model | MGI Sequence Detail 144155 C57BL/6J ±  kb
transcript OTTMUST00000000803 VEGA | MGI Sequence Detail 3888 Not Applicable 
polypeptide OTTMUSP00000000364 VEGA | MGI Sequence Detail 966 Not Applicable 

For the selected sequences
All sequences(142) RefSeq(28) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(903 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 domain
InterPro IPR001478 PDZ domain
InterPro IPR011993 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
InterPro IPR016137 RGS domain
InterPro IPR024066 RGS, subdomain 1
Protein Ontology PR:000013958 regulator of G-protein signaling 3
References
(Earliest) J:64314 Linares JL, et al., C2PA, a new protein expressed during mouse spermatogenesis. FEBS Lett. 2000 Sep 1;480(2-3):249-54
(Latest) J:210195 Williams JW, et al., RGS3 controls T lymphocyte migration in a model of Th2-mediated airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15;305(10):L693-701
All references(41)
Other
accession IDs
MGI:1889637, MGI:1921949

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory