Dmrt1
Gene Detail

Symbol Name ID

Dmrt1 doublesex and mab-3 related transcription factor 1 MGI:1354733

Feature Type

protein coding gene

Genetic Map

Chromosome 19

20.45 cM, cytoband C2-C3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:25505618-25604329 bp, + strand From VEGA annotation of GRCm38   98712 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9280  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Dmrt1

Human homologs

Human Homolog		DMRT1, doublesex and mab-3 related transcription factor 1
NCBI Gene ID		1761
neXtProt AC		NX_Q9Y5R6
Human Synonyms		CT154, DMT1
Human Chr (Location)		9p24.3; chr9:841647-969090 (+)  GRCh38

Alleles and phenotypes

All alleles(30) : Gene trapped(25) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Males homozygous for null mutations are sterile and exhibit a complete loss of germ cells between postnatal days 7-14, disorganized seminiferous tubules, and degeneration of Leydig cells. Females are normal and fertile.

 

Gene Ontology (GO) classifications

All GO classifications: (39 annotations)

Process	cell differentiation, cell morphogenesis, ...
Component	cytoplasm, intracellular, ...
Function	chromatin binding, core promoter proximal region sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (19 records)

Data Summary: Results (359)    Tissues (163)    Images (17)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	132
Northern blot	20
RT-PCR	207

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(1) cDNA(13) Primer pair(6)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000034256 (Evidence)
Ensembl Gene Model	ENSMUSG00000024837 (Evidence)
Entrez Gene	50796 (Evidence)
UniGene	391208
DFCI	TC1594829, TC1598595
DoTS	DT.102547751, DT.102554486, DT.55282145
NIA Mouse Gene Index	U095651
Consensus CDS Project	CCDS29717.1
International Mouse Knockout Project Status	Dmrt1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034256	VEGA Gene Model | MGI Sequence Detail	98712	C57BL/6J
transcript	OTTMUST00000087042	VEGA | MGI Sequence Detail	2340	Not Applicable
polypeptide	OTTMUSP00000047195	VEGA | MGI Sequence Detail	374	Not Applicable

All sequences(37) RefSeq(4) UniProt(1)

Polymorphisms

SNPs within 2kb(617 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001275	DM DNA-binding
InterPro	IPR026607	DMRT/protein doublesex/protein male abnormal 3
InterPro	IPR022114	Doublesex- and mab-3-related transcription factor 1-like
Protein Ontology	PR:000006542	doublesex- and mab-3-related transcription factor 1

References

(Earliest) J:58410 Raymond CS, et al., Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development. Dev Biol. 1999 Nov 15;215(2):208-20
(Latest) J:203322 Hussain S, et al., The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation. Mol Cell Biol. 2013 Apr;33(8):1561-70
All references(66)