About   Help   FAQ
Dmrt1 Gene Detail
Summary
  • Symbol
    Dmrt1
  • Name
    doublesex and mab-3 related transcription factor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354733
    NCBI Gene: 50796
  • Gene Overview
    MyGene.info: DMRT1
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:25505618-25604328 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 20.45 cM, cytoband C2-C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    610 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354733
 protein coding gene Chr19:25505618-25604329 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025002
 protein coding gene Chr19:23803753-23912715 (+)
A/J MGP_AJ_G0024979
 protein coding gene Chr19:22512886-22613691 (+)
AKR/J MGP_AKRJ_G0024947
 protein coding gene Chr19:23354440-23473996 (+)
BALB/cJ MGP_BALBcJ_G0024978
 protein coding gene Chr19:22557334-22659460 (+)
C3H/HeJ MGP_C3HHeJ_G0024734
 protein coding gene Chr19:23335707-23454908 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025419
 protein coding gene Chr19:24537964-24644733 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022838
 protein coding gene Chr19:22634852-22735084 (+)
CAST/EiJ MGP_CASTEiJ_G0024204
 protein coding gene Chr19:23088424-23201557 (+)
CBA/J MGP_CBAJ_G0024712
 protein coding gene Chr19:25598115-25716099 (+)
DBA/2J MGP_DBA2J_G0024844
 protein coding gene Chr19:22506992-22607191 (+)
FVB/NJ MGP_FVBNJ_G0024806
 protein coding gene Chr19:22406450-22507379 (+)
LP/J MGP_LPJ_G0024929
 protein coding gene Chr19:23746303-23863307 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024833
 protein coding gene Chr19:25591875-25697605 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025474
 protein coding gene Chr19:23382518-23494423 (+)
PWK/PhJ MGP_PWKPhJ_G0023952
 protein coding gene Chr19:22132385-22247914 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0024271
 protein coding gene Chr19:23405867-23515680 (+)



Homology
more
  • Human Ortholog
    DMRT1, doublesex and mab-3 related transcription factor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DMRT1, doublesex and mab-3 related transcription factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT154, DMT1
  • Links
    NCBI Gene ID: 1761
    neXtProt AC: NX_Q9Y5R6
    UniProt: Q9Y5R6

  • Chr Location
    9p24.3; chr9:841647-969090 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 9280
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DMRT1
  • Gene Tree
    Dmrt1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Males homozygous for null mutations are sterile and exhibit a complete loss of germ cells between postnatal days 7-14, disorganized seminiferous tubules, and degeneration of Leydig cells. Females are normal and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    999
  • Tissues
    170
  • cDNA Data
    13
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50796 NCBI Gene Model | MGI Sequence Detail 98711 C57BL/6J ±  kb
    transcript NM_015826 RefSeq | MGI Sequence Detail 2251 Not Specified  
    polypeptide Q9QZ59 UniProt | EBI | MGI Sequence Detail 374 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000006542 doublesex- and mab-3-related transcription factor 1
      (term hierarchy)
    • InterPro Domains
      IPR001275 DM DNA-binding domain
      IPR036407 DM DNA-binding domain superfamily
      IPR026607 DMRT/protein doublesex/protein male abnormal 3
      IPR022114 Doublesex- and mab-3-related transcription factor 1-like
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 1
      cDNA 14
      Primer pair 7
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 31
      Gene Ontology 14
      Phenotypes 18
    • Earliest
      J:58410 Raymond CS, et al., Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development. Dev Biol. 1999 Nov 15;215(2):208-20
    • Latest
      J:290670 Eozenou C, et al., Testis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 (WT1) gene. Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13680-13688
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    11/10/2020
    MGI 6.16     		The Jackson Laboratory