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Dmrt1
Gene Detail
 Symbol
Name
ID
Dmrt1
doublesex and mab-3 related transcription factor 1
MGI:1354733
Feature Type protein coding gene
Genetic Map
Chromosome 19
20.45 cM, cytoband C2-C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:25505618-25604329 bp, + strand
From VEGA annotation of GRCm38

  98712 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9280  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Gene Tree: Dmrt1

Human
homologs
Human Homolog DMRT1, doublesex and mab-3 related transcription factor 1
NCBI Gene ID 1761
neXtProt AC  NX_Q9Y5R6
Human Synonyms  CT154, DMT1
Human Chr (Location)  9p24.3; chr9:841647-969090 (+)  GRCh38
Alleles
and
phenotypes
All alleles(30) : Targeted(5) Gene trapped(25)
 
Males homozygous for null mutations are sterile and exhibit a complete loss of germ cells between postnatal days 7-14, disorganized seminiferous tubules, and degeneration of Leydig cells. Females are normal and fertile.
 
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process cell differentiation, cell morphogenesis, ...
Component cytoplasm, intracellular, ...
Function chromatin binding, core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (359)    Tissues (163)    Images (17)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 132
Northern blot 20
RT-PCR 207
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(13) Primer pair(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034256 (Evidence)
Ensembl Gene ModelENSMUSG00000024837 (Evidence)
Entrez Gene50796 (Evidence)
UniGene391208
DFCITC1594829, TC1598595
DoTSDT.102547751, DT.102554486, DT.55282145
NIA Mouse Gene IndexU095651
Consensus CDS ProjectCCDS29717.1
International Mouse Knockout Project StatusDmrt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034256 VEGA Gene Model | MGI Sequence Detail 98712 C57BL/6J ±  kb
transcript OTTMUST00000087042 VEGA | MGI Sequence Detail 2340 Not Applicable 
polypeptide OTTMUSP00000047195 VEGA | MGI Sequence Detail 374 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(617 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001275 DM DNA-binding
InterPro IPR026607 DMRT/protein doublesex/protein male abnormal 3
InterPro IPR022114 Doublesex- and mab-3-related transcription factor 1-like
Protein Ontology PR:000006542 doublesex- and mab-3-related transcription factor 1
References (Earliest) J:58410 Raymond CS, et al., Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development. Dev Biol. 1999 Nov 15;215(2):208-20
(Latest) J:203322 Hussain S, et al., The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation. Mol Cell Biol. 2013 Apr;33(8):1561-70
All references(65)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory