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Dmrt1 Gene Detail
Summary
  • Symbol
    Dmrt1
  • Name
    doublesex and mab-3 related transcription factor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354733
    NCBI Gene: 50796
  • Gene Overview
    MyGene.info: DMRT1
Location & Maps
more
  • Sequence Map
    Chr19:25505618-25604329 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      98712 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 20.45 cM, cytoband C2-C3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DMRT1, doublesex and mab-3 related transcription factor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DMRT1, doublesex and mab-3 related transcription factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT154, DMT1
  • Links
    NCBI Gene ID: 1761
    neXtProt AC: NX_Q9Y5R6
    UniProt: Q9Y5R6

  • Chr Location
    9p24.3; chr9:841647-969090 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 9280
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DMRT1
  • Gene Tree
    Dmrt1
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males homozygous for null mutations are sterile and exhibit a complete loss of germ cells between postnatal days 7-14, disorganized seminiferous tubules, and degeneration of Leydig cells. Females are normal and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    40
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    366
  • Tissues
    170
  • cDNA Data
    12
  • Literature Summary
    26
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034256 VEGA Gene Model | MGI Sequence Detail 98712 C57BL/6J ±  kb
transcript OTTMUST00000087042 VEGA | MGI Sequence Detail 2340 Not Applicable  
polypeptide OTTMUSP00000047195 VEGA | MGI Sequence Detail 374 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    610 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006542 doublesex- and mab-3-related transcription factor 1
    (term hierarchy)
  • InterPro Domains
    IPR001275 DM DNA-binding domain
    IPR026607 DMRT/protein doublesex/protein male abnormal 3
    IPR022114 Doublesex- and mab-3-related transcription factor 1-like
Molecular
Reagents
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  • All nucleic 22
    Genomic 1
    cDNA 13
    Primer pair 7
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 73
    Developmental Gene Expression 26
    Gene Ontology 13
    Phenotypes 17
  • Earliest
    J:58410 Raymond CS, et al., Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development. Dev Biol. 1999 Nov 15;215(2):208-20
  • Latest
    J:235683 Lovelace DL, et al., The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia. Development. 2016 Jun 1;143(11):1893-906
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/20/2017
MGI 6.10 		The Jackson Laboratory