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Rgs6 Gene Detail
Summary
  • Symbol
    Rgs6
  • Name
    regulator of G-protein signaling 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354730
    NCBI Gene: 50779
  • Gene Overview
    MyGene.info: RGS6
Location & Maps
more
  • Sequence Map
    Chr12:82588292-83162056 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      573765 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 38.14 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RGS6, regulator of G protein signaling 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RGS6, regulator of G protein signaling 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GAP, HA117, S914
  • Links
    NCBI Gene ID: 9628
    neXtProt AC: NX_P49758
    UniProt: P49758

  • Chr Location
    14q24.2; chr14:71932100-72632478 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased heart rate and abnormal impulse conducting system conduction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    15
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029345 VEGA Gene Model | MGI Sequence Detail 573765 C57BL/6J ±  kb
transcript OTTMUST00000125215 VEGA | MGI Sequence Detail 1621 Not Applicable  
polypeptide OTTMUSP00000067938 VEGA | MGI Sequence Detail 505 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    3161 from dbSNP Build 142
  • RFLP
    1
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 1
    cDNA 15

    Microarray probesets 5
References
more
  • Summaries
    All 45
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:69278 Nagata Y, et al., A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood. 2001 May 15;97(10):3051-60
  • Latest
    J:239022 Klein AD, et al., Identification of Modifier Genes in a Mouse Model of Gaucher Disease. Cell Rep. 2016 Sep 06;16(10):2546-53
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
08/15/2017
MGI 6.10 		The Jackson Laboratory