Rgs6 MGI Mouse Gene Detail - MGI:1354730 - regulator of G-protein signaling 6

Symbol

Rgs6
Name

regulator of G-protein signaling 6

Feature Type

protein coding gene
IDs

MGI:1354730
NCBI Gene: 50779
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr12:82663325-83208835 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 38.14 cM
Mapping Data

2 experiments

SNPs within 2kb

30976 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354730	protein coding gene	Chr12:82635066-83208835 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019911	protein coding gene	Chr12:83142127-83757388 (+)
A/J	MGP_AJ_G0019868	protein coding gene	Chr12:80027962-80600803 (+)
AKR/J	MGP_AKRJ_G0019844	protein coding gene	Chr12:82188975-82778691 (+)
BALB/cJ	MGP_BALBcJ_G0019848	protein coding gene	Chr12:80364523-80949067 (+)
C3H/HeJ	MGP_C3HHeJ_G0019654	protein coding gene	Chr12:82657536-83240339 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020300	protein coding gene	Chr12:85548005-86160254 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017917	protein coding gene	Chr12:76996216-77543677 (+)
CAST/EiJ	MGP_CASTEiJ_G0019203	protein coding gene	Chr12:77578910-78189880 (+)
CBA/J	MGP_CBAJ_G0019625	protein coding gene	Chr12:88802572-89467943 (+)
DBA/2J	MGP_DBA2J_G0019740	protein coding gene	Chr12:79598338-80162454 (+)
FVB/NJ	MGP_FVBNJ_G0019726	protein coding gene	Chr12:78524189-79095895 (+)
LP/J	MGP_LPJ_G0019812	protein coding gene	Chr12:83044059-83631348 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019765	protein coding gene	Chr12:91867673-92475828 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020334	protein coding gene	Chr12:81773374-82382554 (+)
PWK/PhJ	MGP_PWKPhJ_G0018967	protein coding gene	Chr12:74044462-74622239 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018762	protein coding gene	Chr12:76261561-76840342 (+)
WSB/EiJ	MGP_WSBEiJ_G0019255	protein coding gene	Chr12:82432307-83027582 (+)

Human Ortholog

RGS6, regulator of G protein signaling 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RGS6, regulator of G protein signaling 6
Synonyms

GAP, HA117, S914
Links

HGNC:10002

NCBI Gene ID: 9628

UniProt: P49758
Chr Location

14q24.2; chr14:71867335-72630029 (+) GRCh38

MGI Vertebrate Homology

Rgs6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RGS6
Gene Tree

Rgs6

Diseases

1 with human RGS6 associations

				Human Disease	Mouse Models
				alcohol dependence IDs alcohol dependence DOID:0050741 KEGG:05034 OMIM:103780

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

1
Genomic Mutations

1 involving Rgs6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased heart rate and abnormal impulse conducting system conduction.

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All GO Annotations

33
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

3
cDNA Data

15
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rgs6

ZFIN rgs6

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All Sequences

118
RefSeq

27
UniProt

17
CCDS

CCDS79131.1, CCDS79132.1

Ensembl

ENSMUSG00000021219 (Evidence)
NCBI Gene

50779

			Length	Strain/Species	Flank
genomic	50779	NCBI Gene Model \| MGI Sequence Detail	545511	C57BL/6J	± kb
transcript	NR_182187	RefSeq \| MGI Sequence Detail	6335	ZRU/MplStud
polypeptide	Q9Z2H2	UniProt \| EBI \| MGI Sequence Detail	472	Not Applicable

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UniProt

17 Sequences
Protein Ontology

PR:000013961 regulator of G-protein signaling 6

(term hierarchy)
InterPro Domains

IPR000591 DEP domain

IPR015898 G-protein gamma-like domain

IPR036284 G-protein gamma-like domain superfamily

IPR047016 Regulator of G protein signaling 6/7/9/11

IPR047017 Regulator of G-protein signalling 6/7/9/11, DHEX domain superfamily

IPR040759 Regulator of G-protein signalling, DHEX domain

IPR037956 RGS6, RGS domain

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR024066 RGS, subdomain 1/3

IPR044926 RGS, subdomain 2

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

Q9Z2H2 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 17

Genomic 2

cDNA 15

Microarray probesets 5

Summaries

All 59

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 23
Earliest

J:69278 Nagata Y, et al., A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood. 2001 May 15;97(10):3051-60
Latest

J:366933 DeBaker MC, et al., RGS6 negatively regulates inhibitory G protein signaling in dopamine neurons and positively regulates binge-like alcohol consumption in mice. Br J Pharmacol. 2023 Aug;180(16):2140-2155

TSS for Rgs6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114245	Chr12:82663286-82663316 (+)	-24 bp
Tssr114246	Chr12:82663351-82663355 (+)	28 bp
Tssr114247	Chr12:82663659-82663745 (+)	377 bp
Tssr114248	Chr12:82663785-82663800 (+)	468 bp
Tssr114249	Chr12:82663876-82663890 (+)	558 bp
Tssr114250	Chr12:82753828-82753839 (+)	90,509 bp
Tssr114251	Chr12:82754310-82754355 (+)	91,008 bp
Tssr114252	Chr12:82817501-82817507 (+)	154,179 bp
Tssr114253	Chr12:83074991-83074995 (+)	411,668 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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