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Rgs6 Gene Detail
Summary
  • Symbol
    Rgs6
  • Name
    regulator of G-protein signaling 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354730
    NCBI Gene: 50779
  • Gene Overview
    MyGene.info: RGS6
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:82616551-83162061 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 38.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3039 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354730
 protein coding gene Chr12:82588292-83162061 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019911
 protein coding gene Chr12:83142127-83757388 (+)
A/J MGP_AJ_G0019868
 protein coding gene Chr12:80027962-80600803 (+)
AKR/J MGP_AKRJ_G0019844
 protein coding gene Chr12:82188975-82778691 (+)
BALB/cJ MGP_BALBcJ_G0019848
 protein coding gene Chr12:80364523-80949067 (+)
C3H/HeJ MGP_C3HHeJ_G0019654
 protein coding gene Chr12:82657536-83240339 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020300
 protein coding gene Chr12:85548005-86160254 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017917
 protein coding gene Chr12:76996216-77543677 (+)
CAST/EiJ MGP_CASTEiJ_G0019203
 protein coding gene Chr12:77578910-78189880 (+)
CBA/J MGP_CBAJ_G0019625
 protein coding gene Chr12:88802572-89467943 (+)
DBA/2J MGP_DBA2J_G0019740
 protein coding gene Chr12:79598338-80162454 (+)
FVB/NJ MGP_FVBNJ_G0019726
 protein coding gene Chr12:78524189-79095895 (+)
LP/J MGP_LPJ_G0019812
 protein coding gene Chr12:83044059-83631348 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019765
 protein coding gene Chr12:91867673-92475828 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020334
 protein coding gene Chr12:81773374-82382554 (+)
PWK/PhJ MGP_PWKPhJ_G0018967
 protein coding gene Chr12:74044462-74622239 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018762
 protein coding gene Chr12:76261561-76840342 (+)
WSB/EiJ MGP_WSBEiJ_G0019255
 protein coding gene Chr12:82432307-83027582 (+)



Homology
more
  • Human Ortholog
    RGS6, regulator of G protein signaling 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RGS6, regulator of G protein signaling 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GAP, HA117, S914
  • Links
    NCBI Gene ID: 9628
    neXtProt AC: NX_P49758
    UniProt: P49758

  • Chr Location
    14q24.2; chr14:71932100-72632478 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased heart rate and abnormal impulse conducting system conduction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    15
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 50779 NCBI Gene Model | MGI Sequence Detail 545511 C57BL/6J ±  kb
transcript NM_001310478 RefSeq | MGI Sequence Detail 6037 C57BL/6  
polypeptide Q9Z2H2 UniProt | EBI | MGI Sequence Detail 472 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 2
    cDNA 15

    Microarray probesets 5
References
more
  • Summaries
    All 47
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 17
  • Earliest
    J:69278 Nagata Y, et al., A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood. 2001 May 15;97(10):3051-60
  • Latest
    J:261949 Kulkarni K, et al., The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart. PLoS One. 2018;13(4):e0193798
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/03/2019
MGI 6.14 		The Jackson Laboratory