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Rgs6
Gene Detail
Symbol

Name
ID
Rgs6
regulator of G-protein signaling 6
MGI:1354730
Feature Type
protein coding gene
Genetic Map
Chromosome 12
38.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:82616925-83162056 bp, + strand
From VEGA annotation of GRCm38

  545132 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68385  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RGS6
Protein SuperFamily: regulator of G protein signaling, RGS7 type
Gene Tree: Rgs6

Human
homologs
RGS6, regulator of G-protein signaling 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9628
neXtProt AC: NX_P49758

Human Synonyms: GAP

Human Chr (Location): 14q24.3; chr14:71932100-72566530 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased heart rate and abnormal impulse conducting system conduction.
 
Interactions
Rgs6 interacts with 115 markers (Mir16-1, Mir16-2, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process G-protein coupled receptor signaling pathway, intracellular signal transduction, ...
Component cytoplasm, Golgi apparatus, ...
Function GTPase activator activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rgs6 ; ZFIN rgs6    NEW 
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(13)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000029345 (Evidence)
Ensembl Gene Model ENSMUSG00000021219 (Evidence)
Entrez Gene 50779 (Evidence)
UniGene 153013
DFCI TC1584786
DoTS DT.91406337, DT.40184638, DT.101717573
NIA Mouse Gene Index U014169
International Mouse Phenotyping Consortium Status Rgs6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029345 VEGA Gene Model | MGI Sequence Detail 545132 C57BL/6J ±  kb
transcript OTTMUST00000125361 VEGA | MGI Sequence Detail 1676 Not Applicable 
polypeptide OTTMUSP00000067985 VEGA | MGI Sequence Detail 552 Not Applicable 

For the selected sequences
All sequences(100) RefSeq(20) UniProt(13)
Polymorphisms
RFLP(1) : SNPs within 2kb(3059 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3061)
Protein-related
information
ResourceIDDescription
InterPro IPR000591 DEP domain
InterPro IPR015898 G-protein gamma-like domain
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR016137 Regulator of G protein signalling superfamily
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000013961 regulator of G-protein signaling 6
References
(Earliest) J:69278 Nagata Y, et al., A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood. 2001 May 15;97(10):3051-60
(Latest) J:220008 Stewart A, et al., Regulator of G protein signaling 6 is a critical mediator of both reward-related behavioral and pathological responses to alcohol. Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E786-95
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory