Rgs6 MGI Mouse Gene Detail - MGI:1354730 - regulator of G-protein signaling 6

Symbol

Rgs6
Name

regulator of G-protein signaling 6

Feature Type

protein coding gene
IDs

MGI:1354730
NCBI Gene: 50779
Gene Overview

MyGene.info: RGS6
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:82616551-83162061 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 38.14 cM
Mapping Data

2 experiments

SNPs within 2kb

3039 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354730	protein coding gene	Chr12:82588292-83162061 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019911	protein coding gene	Chr12:83142127-83757388 (+)
A/J	MGP_AJ_G0019868	protein coding gene	Chr12:80027962-80600803 (+)
AKR/J	MGP_AKRJ_G0019844	protein coding gene	Chr12:82188975-82778691 (+)
BALB/cJ	MGP_BALBcJ_G0019848	protein coding gene	Chr12:80364523-80949067 (+)
C3H/HeJ	MGP_C3HHeJ_G0019654	protein coding gene	Chr12:82657536-83240339 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020300	protein coding gene	Chr12:85548005-86160254 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017917	protein coding gene	Chr12:76996216-77543677 (+)
CAST/EiJ	MGP_CASTEiJ_G0019203	protein coding gene	Chr12:77578910-78189880 (+)
CBA/J	MGP_CBAJ_G0019625	protein coding gene	Chr12:88802572-89467943 (+)
DBA/2J	MGP_DBA2J_G0019740	protein coding gene	Chr12:79598338-80162454 (+)
FVB/NJ	MGP_FVBNJ_G0019726	protein coding gene	Chr12:78524189-79095895 (+)
LP/J	MGP_LPJ_G0019812	protein coding gene	Chr12:83044059-83631348 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019765	protein coding gene	Chr12:91867673-92475828 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020334	protein coding gene	Chr12:81773374-82382554 (+)
PWK/PhJ	MGP_PWKPhJ_G0018967	protein coding gene	Chr12:74044462-74622239 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018762	protein coding gene	Chr12:76261561-76840342 (+)
WSB/EiJ	MGP_WSBEiJ_G0019255	protein coding gene	Chr12:82432307-83027582 (+)

Human Ortholog

RGS6, regulator of G protein signaling 6

Vertebrate Orthologs

10

Human Ortholog

RGS6, regulator of G protein signaling 6
Orthology source: HomoloGene, HGNC
Synonyms

GAP, HA117, S914
Links

HGNC:10002

NCBI Gene ID: 9628

neXtProt AC: NX_P49758

UniProt: P49758
Chr Location

14q24.2; chr14:71932100-72632478 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 68385
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: RGS6
Protein SuperFamily

regulator of G protein signaling, RGS7 type
Gene Tree

Rgs6

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Gene trapped

1
Targeted

1
Genomic Mutations

1 involving Rgs6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased heart rate and abnormal impulse conducting system conduction.

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All GO Annotations

18
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
cDNA Data

15
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rgs6

ZFIN rgs6

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Rgs6 interacts with 115 markers (Mir16-1, Mir16-2, Mir22, ...) View All

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All Sequences

115
RefSeq

24
UniProt

17
CCDS

CCDS79131.1, CCDS79132.1
UniGene

153013

Ensembl

ENSMUSG00000021219 (Evidence)
NCBI Gene

50779

			Length	Strain/Species	Flank
genomic	50779	NCBI Gene Model \| MGI Sequence Detail	545511	C57BL/6J	± kb
transcript	NM_001310478	RefSeq \| MGI Sequence Detail	6037	C57BL/6
polypeptide	Q9Z2H2	UniProt \| EBI \| MGI Sequence Detail	472	Not Applicable

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UniProt

17 Sequences
Protein Ontology

PR:000013961 regulator of G-protein signaling 6

(term hierarchy)
InterPro Domains

IPR000591 DEP domain

IPR015898 G-protein gamma-like domain

IPR036284 G-protein gamma-like domain superfamily

IPR040759 Regulator of G-protein signalling, DHEX domain

IPR037956 RGS6, RGS domain

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR024066 RGS, subdomain 1/3

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 17

Genomic 2

cDNA 15

Microarray probesets 5

Summaries

All 49

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 19
Earliest

J:69278 Nagata Y, et al., A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood. 2001 May 15;97(10):3051-60
Latest

J:294115 Anderson A, et al., GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14522-14531

TSS for Rgs6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114245	Chr12:82616512-82616542 (+)	-24 bp
Tssr114246	Chr12:82616577-82616581 (+)	28 bp
Tssr114247	Chr12:82616885-82616971 (+)	377 bp
Tssr114248	Chr12:82617011-82617026 (+)	468 bp
Tssr114249	Chr12:82617102-82617116 (+)	558 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/13/2020 MGI 6.16