Rgs6
Gene Detail

Symbol Name ID

Rgs6 regulator of G-protein signaling 6 MGI:1354730

Feature Type

protein coding gene

Genetic Map

Chromosome 12

38.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:82616925-83092731 bp, + strand From VEGA annotation of GRCm38   475807 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68385  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: regulator of G protein signaling, RGS7 type
Gene Tree: Rgs6

Human homologs

Human Homolog		RGS6, regulator of G-protein signaling 6
NCBI Gene ID		9628
neXtProt AC		NX_P49758
Human Synonyms		GAP
Human Chr (Location)		14q24.3; chr14:71932100-72566530 (+)  GRCh38

Alleles and phenotypes

All alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit decreased heart rate and abnormal impulse conducting system conduction.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	G-protein coupled receptor signaling pathway, intracellular signal transduction, ...
Component	cytoplasm, Golgi apparatus, ...
Function	GTPase activator activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(1) cDNA(13)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000029345 (Evidence)
Ensembl Gene Model	ENSMUSG00000021219 (Evidence)
Entrez Gene	50779 (Evidence)
UniGene	153013
DFCI	TC1584786
DoTS	DT.101717573, DT.40184638, DT.91406337
NIA Mouse Gene Index	U014169
International Mouse Knockout Project Status	Rgs6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029345	VEGA Gene Model | MGI Sequence Detail	475807	C57BL/6J
transcript	OTTMUST00000072708	VEGA | MGI Sequence Detail	2139	Not Applicable
polypeptide	OTTMUSP00000037496	VEGA | MGI Sequence Detail	335	Not Applicable

All sequences(48) RefSeq(18) UniProt(5)

Polymorphisms

RFLP(1) : SNPs within 2kb(3049 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3051)

Protein-related information

Resource	ID	Description
InterPro	IPR000591	DEP domain
InterPro	IPR015898	G-protein gamma-like domain
InterPro	IPR024066	Regulator of G-protein signaling, domain 1
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000013961	regulator of G-protein signaling 6

References

(Earliest) J:69278 Nagata Y, et al., A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood. 2001 May 15;97(10):3051-60
(Latest) J:209527 Wydeven N, et al., RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate. J Biol Chem. 2014 Jan 24;289(4):2440-9
All references(41)