Rgs6 Gene Detail

Summary

• Symbol
  Rgs6
• Name
  regulator of G-protein signaling 6

• Feature Type
  protein coding gene
• IDs
  MGI:1354730
  NCBI Gene: 50779
• Gene Overview
  MyGene.info: RGS6
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr12:82588292-83162056 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    573765 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 12, 38.14 cM
• Mapping Data
  2 experiments

Homology

• Human Ortholog
  RGS6, regulator of G protein signaling 6

• Vertebrate Orthologs
  10

• Human Ortholog
  RGS6, regulator of G protein signaling 6
  Orthology source: HomoloGene, HGNC
• Synonyms
  GAP, HA117, S914
• Links
  HGNC:10002

  NCBI Gene ID: 9628

  neXtProt AC: NX_P49758

  UniProt: P49758

  
  
• Chr Location
  14q24.2; chr14:71932100-72632478 (+)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 68385
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: RGS6
• Protein SuperFamily
  regulator of G protein signaling, RGS7 type
• Gene Tree
  Rgs6
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 1 allele in 1 genetic background
  16 phenotype references
  

• All Mutations and Alleles
  3
• Chemically induced (other)
  1
• Gene trapped
  1
• Targeted
  1
• Genomic Mutations
  1 involving Rgs6
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  16 strains or lines available

Mice homozygous for a knock-out allele exhibit decreased heart rate and abnormal impulse conducting system conduction.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  19
• GO References
  8

• External Resources
  FuncBase

Expression

• cDNA Data
  15
• Literature Summary
  1

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase rgs6
  ZFIN rgs6

Interactions

• Rgs6 interacts with 115 markers (Mir16-1, Mir16-2, Mir22, ...) View All

Sequences &
Gene Models

• All Sequences
  133
• RefSeq
  20
• UniProt
  17
• CCDS
  CCDS79131.1, CCDS79132.1
• UniGene
  153013

• VEGA
  OTTMUSG00000029345 (Evidence)
• Ensembl
  ENSMUSG00000021219 (Evidence)
• NCBI Gene
  50779

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000029345	VEGA Gene Model | MGI Sequence Detail	573765	C57BL/6J
transcript	OTTMUST00000125215	VEGA | MGI Sequence Detail	1621	Not Applicable
polypeptide	OTTMUSP00000067938	VEGA | MGI Sequence Detail	505	Not Applicable

Polymorphisms

• SNPs within 2kb
  3161 from dbSNP Build 142

• RFLP
  1

Protein
Information

• UniProt
  17 Sequences
• InterPro Domains
  IPR000591 DEP domain
  IPR015898 G-protein gamma-like domain
  IPR036284 G-protein gamma-like domain superfamily
  IPR037956 RGS6, RGS domain
  IPR016137 RGS domain
  IPR036305 RGS domain superfamily
  IPR024066 RGS, subdomain 1/3
  IPR036390 Winged helix DNA-binding domain superfamily
  IPR036388 Winged helix-like DNA-binding domain superfamily

Molecular
Reagents

• All nucleic 16

  Genomic 1

  cDNA 15

  
  

  Microarray probesets 5

References

• Summaries
  All 46

  Developmental Gene Expression 1

  Gene Ontology 8

  Phenotypes 16
• Earliest
  J:69278 Nagata Y, et al., A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood. 2001 May 15;97(10):3051-60
• Latest
  J:261949 Kulkarni K, et al., The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart. PLoS One. 2018;13(4):e0193798