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Smtn
Gene Detail
Symbol

Name
ID
Smtn
smoothelin
MGI:1354727
Feature Type
protein coding gene
Genetic Map
Chromosome 11
2.47 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:3517523-3540612 bp, - strand
From VEGA annotation of GRCm38

  23090 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8482  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: SMTN
Gene Tree: Smtn

Human
homologs
SMTN, smoothelin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6525
neXtProt AC: NX_P53814

Human Chr (Location): 22q12.2; chr22:31064180-31104624 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions of both the A and B isoforms of this gene display partial postnatal lethality, impaired intestinal smooth muscle contractility and thus hampered intestinal transit and diverticulosis. Mice lacking only the B isoform appear normal.
 
Interactions
Smtn interacts with 69 markers (Mir16-2, Mir18b, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Component actin cytoskeleton, cytoplasm, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (140)    Tissues (11)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 140
cDNA source data(113)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase smtn ; ZFIN smtnb    NEW 
Molecular
reagents
All nucleic(115) cDNA(115)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005025 (Evidence)
Ensembl Gene Model ENSMUSG00000020439 (Evidence)
Entrez Gene 29856 (Evidence)
UniGene 188516
DFCI TC1572349, TC1588351, TC1591317, TC1725564, TC1748276
DoTS DT.101203334, DT.101737372, DT.492950, DT.91362126, DT.91439632, DT.97368513, DT.99864018
NIA Mouse Gene Index U032434
Consensus CDS Project CCDS24366.1, CCDS70129.1
International Mouse Phenotyping Consortium Status Smtn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005025 VEGA Gene Model | MGI Sequence Detail 23090 C57BL/6J ±  kb
transcript OTTMUST00000011173 VEGA | MGI Sequence Detail 3020 Not Applicable 
polypeptide OTTMUSP00000005210 VEGA | MGI Sequence Detail 946 Not Applicable 

For the selected sequences
All sequences(103) RefSeq(22) UniProt(6)
Polymorphisms
SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001715 Calponin homology domain
InterPro IPR022189 Smoothelin cytoskeleton protein
Protein Ontology PR:000015302 smoothelin
References
(Earliest) J:60544 Kramer J, et al., A novel isoform of the smooth muscle cell differentiation marker smoothelin [see comments] [published erratum appears in J Mol Med 1999 Apr;77(4):399]. J Mol Med. 1999 Feb;77(2):294-8
(Latest) J:179089 Jaffe M, et al., Transforming Growth Factor-beta Signaling in Myogenic Cells Regulates Vascular Morphogenesis, Differentiation, and Matrix Synthesis. Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):e1-e11
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory