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Slc25a13
Gene Detail
 Symbol
Name
ID
Slc25a13
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
MGI:1354721
Synonyms citrin, Ctrn
Feature Type protein coding gene
Genetic Map
Chromosome 6
2.30 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:6041218-6217118 bp, - strand
From VEGA annotation of GRCm38

  175901 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22800  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Slc25a13

Human
homologs
Human Homolog SLC25A13, solute carrier family 25 (aspartate/glutamate carrier), member 13
NCBI Gene ID 10165
neXtProt AC  NX_Q9UJS0
Human Synonyms  ARALAR2, CITRIN, CTLN2
Human Chr (Location)  7q21.3; chr7:96120220-96322147 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human SLC25A13
Mutations,
alleles, and
phenotypes
All mutations/alleles(226) : Gene trapped(225) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene appear normal, healthy and fertile, although they have a number of metabolic defects.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Slc25a13 interacts with 204 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process aspartate transport, ATP biosynthetic process, ...
Component integral component of membrane, membrane, ...
Function calcium ion binding, L-aspartate transmembrane transporter activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (249)    Tissues (67)    Images (27)
Theiler Stages: 17, 20, 21, 23, 28
Assay TypeResults
RNA in situ 247
Northern blot 2
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(14) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000042278 (Evidence)
Ensembl Gene ModelENSMUSG00000015112 (Evidence)
Entrez Gene50799 (Evidence)
DFCITC1575629
DoTSDT.101162755, DT.101197367, DT.527928
NIA Mouse Gene IndexU027026
Consensus CDS ProjectCCDS39421.1
International Mouse Knockout Project StatusSlc25a13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042278 VEGA Gene Model | MGI Sequence Detail 175901 C57BL/6J ±  kb
transcript OTTMUST00000111238 VEGA | MGI Sequence Detail 3067 Not Applicable 
polypeptide OTTMUSP00000062212 VEGA | MGI Sequence Detail 676 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(430 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR023395 Mitochondrial carrier domain
InterPro IPR002067 Mitochondrial carrier protein
InterPro IPR018108 Mitochondrial substrate/solute carrier
Protein Ontology PR:000015008 calcium-binding mitochondrial carrier protein Aralar2
References (Earliest) J:59976 Sinasac DS, et al., Genomic structure of the adult-onset type II citrullinemia gene, SLC25A13, and cloning and expression of its mouse homologue. Genomics. 1999 Dec 1;62(2):289-92
(Latest) J:190044 Saheki T, et al., Effects of supplementation on food intake, body weight and hepatic metabolites in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse model of human citrin deficiency. Mol Genet Metab. 2012 Nov;107(3):322-9
All references(50)
Disease annotation references (1)
Other
accession IDs
MGI:2141468

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory