Slc25a13
Gene Detail

Symbol Name ID

Slc25a13 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 MGI:1354721

Synonyms

citrin, Ctrn

Feature Type

protein coding gene

Genetic Map

Chromosome 6

2.30 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:6041218-6217118 bp, - strand From VEGA annotation of GRCm38   175901 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22800  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Slc25a13

Human homologs

Human Homolog		SLC25A13, solute carrier family 25 (aspartate/glutamate carrier), member 13
NCBI Gene ID		10165
neXtProt AC		NX_Q9UJS0
Human Synonyms		ARALAR2, CITRIN, CTLN2
Human Chr (Location)		7q21.3; chr7:95749532-95951459 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SLC25A13

Alleles and phenotypes

All alleles(226) : Targeted(1) Gene trapped(225)
 

Mice homozygous for disruptions in this gene appear normal, healthy and fertile, although they have a number of metabolic defects.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	amino acid transmembrane transport, aspartate transport, ...
Component	integral to membrane, membrane, ...
Function	calcium ion binding, L-aspartate transmembrane transporter activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (249)    Tissues (67)    Images (27)
Theiler Stages: 17, 20, 21, 23, 28

Assay Type	Results
RNA in situ	247
Northern blot	2

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(14) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000042278 (Evidence)
Ensembl Gene Model	ENSMUSG00000015112 (Evidence)
Entrez Gene	50799 (Evidence)
DFCI	TC1575629
DoTS	DT.101162755, DT.101197367, DT.527928
NIA Mouse Gene Index	U027026
Consensus CDS Project	CCDS39421.1
International Mouse Knockout Project Status	Slc25a13

Sequences

Length	Strain/Species
genomic	OTTMUSG00000042278	VEGA Gene Model | MGI Sequence Detail	175901	C57BL/6J
transcript	OTTMUST00000111238	VEGA | MGI Sequence Detail	3067	Not Applicable
polypeptide	OTTMUSP00000062212	VEGA | MGI Sequence Detail	676	Not Applicable

All sequences(50) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(59 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002048	Calcium-binding EF-hand
InterPro	IPR018249	EF-HAND 2
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR023395	Mitochondrial carrier domain
InterPro	IPR002067	Mitochondrial carrier protein
InterPro	IPR018108	Mitochondrial substrate/solute carrier
Protein Ontology	PR:000015008	calcium-binding mitochondrial carrier protein Aralar2

References

(Earliest) J:59976 Sinasac DS, et al., Genomic structure of the adult-onset type II citrullinemia gene, SLC25A13, and cloning and expression of its mouse homologue. Genomics. 1999 Dec 1;62(2):289-92
(Latest) J:190044 Saheki T, et al., Effects of supplementation on food intake, body weight and hepatic metabolites in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse model of human citrin deficiency. Mol Genet Metab. 2012 Nov;107(3):322-9
All references(49)

Other accession IDs

MGI:2141468