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Acsl4 Gene Detail
Summary
  • Symbol
    Acsl4
  • Name
    acyl-CoA synthetase long-chain family member 4
  • Synonyms
    9430020A05Rik, ACS4, Facl4, Lacs4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354713
    NCBI Gene: 50790
  • Gene Overview
    MyGene.info: ACSL4
Location & Maps
more
  • Sequence Map
    ChrX:142317993-142390535 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      72543 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ACSL4, acyl-CoA synthetase long-chain family member 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACSL4, acyl-CoA synthetase long-chain family member 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACS4, FACL4, LACS4, MRX63, MRX68
  • Links
    NCBI Gene ID: 2182
    neXtProt AC: NX_O60488

  • Chr Location
    Xq22.3-q23; chrX:109641335-109733392 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 56282
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ACSL4
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ACSL4 associations

Human Disease Mouse Models
       Mental Retardation, X-Linked 63; MRX63   OMIM: 300387
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Gene trapped
    15
  • Targeted
    2
  • Incidental Mutations
Female heterozygotes for a targeted null mutation exhibit accumulation of prostaglandins in the uterus, reduced fertility with few and small litters, and very low transmission of the mutant allele.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018811 VEGA Gene Model | MGI Sequence Detail 72543 C57BL/6J ±  kb
transcript OTTMUST00000045274 VEGA | MGI Sequence Detail 5280 Not Applicable  
polypeptide OTTMUSP00000020369 VEGA | MGI Sequence Detail 711 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    332 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000003661 long-chain-fatty-acid--CoA ligase 4
  • EC
  • InterPro Domains
    IPR020845 AMP-binding, conserved site
    IPR000873 AMP-dependent synthetase/ligase
Molecular
Reagents
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  • All nucleic 17
    cDNA 15
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
less
MGI:2147955
References
more
  • Summaries
    All 47
    Developmental Gene Expression 7
    Gene Ontology 10
    Phenotypes 11
  • Earliest
    J:60348 Li Z, et al., Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction [see comments]. Science. 2000 Feb 11;287(5455):1046-9
  • Latest
    J:218247 Cossette SM, et al., Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. Biol Open. 2014;4(1):48-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory