Acsl4 MGI Mouse Gene Detail - MGI:1354713 - acyl-CoA synthetase long-chain family member 4

Symbol

Acsl4
Name

acyl-CoA synthetase long-chain family member 4
Synonyms

9430020A05Rik, ACS4, Facl4, Lacs4

Feature Type

protein coding gene
IDs

MGI:1354713
NCBI Gene: 50790
Gene Overview

MyGene.info: ACSL4
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

ChrX:142317993-142390535 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 63.12 cM
Mapping Data

3 experiments

SNPs within 2kb

332 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354713	protein coding gene	ChrX:142317993-142390800 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0036150	protein coding gene	ChrX:139812687-139895526 (-)
A/J	MGP_AJ_G0036127	protein coding gene	ChrX:139217727-139294061 (-)
AKR/J	MGP_AKRJ_G0036053	protein coding gene	ChrX:143665894-143752552 (-)
BALB/cJ	MGP_BALBcJ_G0036118	protein coding gene	ChrX:137449417-137524231 (-)
C3H/HeJ	MGP_C3HHeJ_G0035826	protein coding gene	ChrX:139918540-139999262 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036641	protein coding gene	ChrX:143832723-143910594 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033465	protein coding gene	ChrX:130785195-130858849 (-)
CAST/EiJ	MGP_CASTEiJ_G0035117	protein coding gene	ChrX:120638888-120712683 (-)
CBA/J	MGP_CBAJ_G0035803	protein coding gene	ChrX:148320475-148406224 (-)
DBA/2J	MGP_DBA2J_G0035961	protein coding gene	ChrX:138284196-138360742 (-)
FVB/NJ	MGP_FVBNJ_G0035895	protein coding gene	ChrX:137511191-137583495 (-)
LP/J	MGP_LPJ_G0036052	protein coding gene	ChrX:140774784-140860777 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035931	protein coding gene	ChrX:155955178-156046660 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036678	protein coding gene	ChrX:139123697-139199567 (-)
PWK/PhJ	MGP_PWKPhJ_G0034811	protein coding gene	ChrX:117450997-117525758 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034636	protein coding gene	ChrX:121148121-121224532 (-)
WSB/EiJ	MGP_WSBEiJ_G0035252	protein coding gene	ChrX:137517305-137591953 (-)

Human Ortholog

ACSL4, acyl-CoA synthetase long chain family member 4

Vertebrate Orthologs

10

Human Ortholog

ACSL4, acyl-CoA synthetase long chain family member 4
Orthology source: HomoloGene, HGNC
Synonyms

ACS4, FACL4, LACS4, MRX63, MRX68
Links

HGNC:3571

NCBI Gene ID: 2182

neXtProt AC: NX_O60488

UniProt: O60488
Chr Location

Xq23; chrX:109641330-109733403 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 56282
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ACSL4
Gene Tree

Acsl4

Diseases

1 with human ACSL4 associations

				Human Disease	Mouse Models
				non-syndromic X-linked intellectual disability IDs non-syndromic X-linked intellectual disability DOID:0050776 OMIM:300046 OMIM:300047 OMIM:300062 OMIM:300114 OMIM:300115 OMIM:300143 OMIM:300210 OMIM:300271 OMIM:300324 OMIM:300355 OMIM:300372 OMIM:300387 OMIM:300428 OMIM:300433 OMIM:300436 OMIM:300454 OMIM:300498 OMIM:300505 OMIM:300518 OMIM:300558 OMIM:300577 OMIM:300659 OMIM:300716 OMIM:300802 OMIM:300803 OMIM:300844 OMIM:300848 OMIM:300849 OMIM:300850 OMIM:300851 OMIM:300852 OMIM:300912 OMIM:300919 OMIM:300923 OMIM:309530 OMIM:309549 ORDO:777

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

20 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Gene trapped

15
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Female heterozygotes for a targeted null mutation exhibit accumulation of prostaglandins in the uterus, reduced fertility with few and small litters, and very low transmission of the mutant allele.

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All GO Annotations

38
GO References

11

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

602
Tissues

191
cDNA Data

15
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ACSL4

Xenbase acsl4

ZFIN acsl4a, acsl4b

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Acsl4 interacts with 395 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

64
RefSeq

12
UniProt

3
CCDS

CCDS30448.1, CCDS41156.1

Ensembl

ENSMUSG00000031278 (Evidence)
NCBI Gene

50790

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031278	Ensembl Gene Model \| MGI Sequence Detail	72543	C57BL/6J	± kb
transcript	ENSMUST00000033634	Ensembl \| MGI Sequence Detail	5280	Not Applicable
polypeptide	ENSMUSP00000033634	Ensembl \| MGI Sequence Detail	711	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003661 long-chain-fatty-acid--CoA ligase 4

(term hierarchy)
EC

6.2.1.15, 6.2.1.3
InterPro Domains

IPR020845 AMP-binding, conserved site

IPR000873 AMP-dependent synthetase/ligase

IPR042099 AMP-dependent synthetase-like superfamily

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All nucleic 18

Genomic 1

cDNA 15

Primer pair 2

Microarray probesets 7

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MGI:2147955

Summaries

All 49

Developmental Gene Expression 7

Gene Ontology 11

Phenotypes 11
Earliest

J:60348 Li Z, et al., Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction [see comments]. Science. 2000 Feb 11;287(5455):1046-9
Latest

J:250633 Kan CF, et al., PPARdelta activation induces hepatic long-chain acyl-CoA synthetase 4 expression in vivo and in vitro. Biochim Biophys Acta. 2015 May;1851(5):577-87

TSS for Acsl4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr164299	ChrX:142390603-142390614 (-)	-74 bp
Tssr164298	ChrX:142390574-142390581 (-)	-43 bp
Tssr164297	ChrX:142390491-142390520 (-)	29 bp
Tssr164296	ChrX:142390434-142390446 (-)	95 bp
Tssr164295	ChrX:142390394-142390428 (-)	124 bp
Tssr164294	ChrX:142390360-142390363 (-)	173 bp
Tssr164293	ChrX:142390334-142390345 (-)	195 bp
Tssr164285	ChrX:142328054-142328066 (-)	62,475 bp
Tssr164284	ChrX:142328032-142328047 (-)	62,495 bp
Tssr164281	ChrX:142320316-142320337 (-)	70,208 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/08/2019 MGI 6.14