Acsl4
Gene Detail

Symbol

Name
ID

Acsl4
acyl-CoA synthetase long-chain family member 4
MGI:1354713

Synonyms

9430020A05Rik, ACS4, Facl4, Lacs4

Feature Type

protein coding gene

Genetic Map

Chromosome X
63.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

ChrX:142317993-142390535 bp, - strand From VEGA annotation of GRCm38   72543 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:56282  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Acsl4

Human
homologs

Human Homolog		ACSL4, acyl-CoA synthetase long-chain family member 4
NCBI Gene ID		2182
neXtProt AC		NX_O60488
Human Synonyms		ACS4, FACL4, LACS4, MRX63, MRX68
Human Chr (Location)		Xq22.3-q23; chrX:109641335-109733392 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human ACSL4

Mutations,
alleles, and
phenotypes

All mutations/alleles(17) : Gene trapped(15) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Female heterozygotes for a targeted null mutation exhibit accumulation of prostaglandins in the uterus, reduced fertility with few and small litters, and very low transmission of the mutant allele.

 

Interactions

Acsl4 interacts with 396 markers (Mir1b, Mir7-1, Mir7-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (38 annotations)

Process	dendritic spine development, embryonic process involved in female pregnancy, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	arachidonate-CoA ligase activity, ATP binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (602)    Tissues (191)    Images (71)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	11
RNA in situ	575
Northern blot	10
RT-PCR	6

cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(17) cDNA(15) Primer pair(2)
Microarray probesets(7)

Other database
links

VEGA Gene Model	OTTMUSG00000018811 (Evidence)
Ensembl Gene Model	ENSMUSG00000031278 (Evidence)
Entrez Gene	50790 (Evidence)
DFCI	TC1579639, TC1589561, TC1597775, TC1634075, TC1747857
DoTS	DT.486629, DT.111024386, DT.101365621, DT.101365416
NIA Mouse Gene Index	U039748
EC	6.2.1.3
Consensus CDS Project	CCDS30448.1, CCDS41156.1
International Mouse Knockout Project Status	Acsl4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018811	VEGA Gene Model | MGI Sequence Detail	72543	C57BL/6J
transcript	OTTMUST00000045277	VEGA | MGI Sequence Detail	5137	Not Applicable
polypeptide	OTTMUSP00000020372	VEGA | MGI Sequence Detail	711	Not Applicable

All sequences(66) RefSeq(10) UniProt(5)

Polymorphisms

SNPs within 2kb(334 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR020845	AMP-binding, conserved site
InterPro	IPR000873	AMP-dependent synthetase/ligase
Protein Ontology	PR:000003661	long-chain-fatty-acid--CoA ligase 4

References

(Earliest) J:60348 Li Z, et al., Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction [see comments]. Science. 2000 Feb 11;287(5455):1046-9
(Latest) J:193737 Smith ME, et al., Long-chain acyl-CoA synthetase 4 is regulated by phosphorylation. Biochem Biophys Res Commun. 2013 Jan 4;430(1):272-7
All references(50)

Other
accession IDs

MGI:2147955