Acsl4 MGI Mouse Gene Detail - MGI:1354713 - acyl-CoA synthetase long-chain family member 4

Acsl4 Gene Detail

Symbol

Acsl4
Name

acyl-CoA synthetase long-chain family member 4
Synonyms

9430020A05Rik, ACS4, Facl4, Lacs4

Feature Type

protein coding gene
IDs

MGI:1354713
NCBI Gene: 50790
Gene Overview

MyGene.info: ACSL4

Sequence Map

ChrX:142317993-142390535 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

72543 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 63.12 cM
Mapping Data

3 experiments

Human Ortholog

ACSL4, acyl-CoA synthetase long chain family member 4

Vertebrate Orthologs

10

Human Ortholog

ACSL4, acyl-CoA synthetase long chain family member 4
Orthology source: HomoloGene, HGNC
Synonyms

ACS4, FACL4, LACS4, MRX63, MRX68
Links

HGNC:3571

NCBI Gene ID: 2182

neXtProt AC: NX_O60488

UniProt: O60488
Chr Location

Xq23; chrX:109641330-109733403 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 56282
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ACSL4
Gene Tree

Acsl4

Diseases

1 with human ACSL4 associations

				Human Disease	Mouse Models
				non-syndromic X-linked intellectual disability IDs non-syndromic X-linked intellectual disability DOID:0050776 OMIM:300046 OMIM:300047 OMIM:300062 OMIM:300114 OMIM:300115 OMIM:300143 OMIM:300210 OMIM:300271 OMIM:300324 OMIM:300355 OMIM:300372 OMIM:300387 OMIM:300428 OMIM:300433 OMIM:300436 OMIM:300454 OMIM:300498 OMIM:300504 OMIM:300505 OMIM:300518 OMIM:300558 OMIM:300577 OMIM:300659 OMIM:300716 OMIM:300802 OMIM:300803 OMIM:300844 OMIM:300848 OMIM:300849 OMIM:300850 OMIM:300851 OMIM:300852 OMIM:300912 OMIM:300919 OMIM:300923 OMIM:309530 OMIM:309549 ORDO:777

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

20 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Gene trapped

15
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available

Female heterozygotes for a targeted null mutation exhibit accumulation of prostaglandins in the uterus, reduced fertility with few and small litters, and very low transmission of the mutant allele.

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All GO Annotations

35
GO References

11

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

602
Tissues

191
cDNA Data

15
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ACSL4

ZFIN acsl4a, acsl4b

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Acsl4 interacts with 395 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

54
RefSeq

10
UniProt

3
CCDS

CCDS30448.1, CCDS41156.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000018811	VEGA Gene Model \| MGI Sequence Detail	72543	C57BL/6J	± kb
transcript	OTTMUST00000045277	VEGA \| MGI Sequence Detail	5137	Not Applicable
polypeptide	OTTMUSP00000020372	VEGA \| MGI Sequence Detail	711	Not Applicable

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SNPs within 2kb

332 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000003661 long-chain-fatty-acid--CoA ligase 4

(term hierarchy)
EC

6.2.1.3
InterPro Domains

IPR020845 AMP-binding, conserved site

IPR000873 AMP-dependent synthetase/ligase

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All nucleic 17

cDNA 15

Primer pair 2

Microarray probesets 7

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MGI:2147955

Summaries

All 48

Developmental Gene Expression 7

Gene Ontology 11

Phenotypes 11
Earliest

J:60348 Li Z, et al., Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction [see comments]. Science. 2000 Feb 11;287(5455):1046-9
Latest

J:218247 Cossette SM, et al., Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. Biol Open. 2014;4(1):48-61

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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