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Acsl4
Gene Detail
 Symbol
Name
ID
Acsl4
acyl-CoA synthetase long-chain family member 4
MGI:1354713
Synonyms 9430020A05Rik, ACS4, Facl4, Lacs4
Feature Type protein coding gene
Genetic Map
Chromosome X
63.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:142317993-142390535 bp, - strand
From VEGA annotation of GRCm38

  72543 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56282  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Acsl4

Human
homologs
Human Homolog ACSL4, acyl-CoA synthetase long-chain family member 4
NCBI Gene ID 2182
neXtProt AC  NX_O60488
Human Synonyms  ACS4, FACL4, LACS4, MRX63, MRX68
Human Chr (Location)  Xq22.3-q23; chrX:109641335-109733392 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ACSL4
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(15) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Female heterozygotes for a targeted null mutation exhibit accumulation of prostaglandins in the uterus, reduced fertility with few and small litters, and very low transmission of the mutant allele.
 
Interactions
Acsl4 interacts with 396 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process dendritic spine development, embryonic process involved in female pregnancy, ...
Component cytoplasm, endoplasmic reticulum, ...
Function arachidonate-CoA ligase activity, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (602)    Tissues (191)    Images (71)
Theiler Stages: 10, 16, 18, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 11
RNA in situ 575
Northern blot 10
RT-PCR 6
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(15) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000018811 (Evidence)
Ensembl Gene ModelENSMUSG00000031278 (Evidence)
Entrez Gene50790 (Evidence)
DFCITC1579639, TC1589561, TC1597775, TC1634075, TC1747857
DoTSDT.101365416, DT.101365621, DT.111024386, DT.486629
NIA Mouse Gene IndexU039748
EC6.2.1.3
Consensus CDS ProjectCCDS30448.1, CCDS41156.1
International Mouse Knockout Project StatusAcsl4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018811 VEGA Gene Model | MGI Sequence Detail 72543 C57BL/6J ±  kb
transcript OTTMUST00000045277 VEGA | MGI Sequence Detail 5137 Not Applicable 
polypeptide OTTMUSP00000020372 VEGA | MGI Sequence Detail 711 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(334 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020845 AMP-binding, conserved site
InterPro IPR000873 AMP-dependent synthetase/ligase
Protein Ontology PR:000003661 long-chain-fatty-acid--CoA ligase 4
References (Earliest) J:60348 Li Z, et al., Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction [see comments]. Science. 2000 Feb 11;287(5455):1046-9
(Latest) J:193737 Smith ME, et al., Long-chain acyl-CoA synthetase 4 is regulated by phosphorylation. Biochem Biophys Res Commun. 2013 Jan 4;430(1):272-7
All references(50)
Other
accession IDs
MGI:2147955

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory