About   Help   FAQ
Help us improve MGI resources by taking this very brief survey.
Acsl4 Gene Detail
Summary
  • Symbol
    Acsl4
  • Name
    acyl-CoA synthetase long-chain family member 4
  • Synonyms
    9430020A05Rik, ACS4, Facl4, Lacs4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354713
    NCBI Gene: 50790
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:141100989-141173531 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 63.12 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    327 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354713
 protein coding gene ChrX:141100989-141173792 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036150
 protein coding gene ChrX:139812687-139895526 (-)
A/J MGP_AJ_G0036127
 protein coding gene ChrX:139217727-139294061 (-)
AKR/J MGP_AKRJ_G0036053
 protein coding gene ChrX:143665894-143752552 (-)
BALB/cJ MGP_BALBcJ_G0036118
 protein coding gene ChrX:137449417-137524231 (-)
C3H/HeJ MGP_C3HHeJ_G0035826
 protein coding gene ChrX:139918540-139999262 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036641
 protein coding gene ChrX:143832723-143910594 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033465
 protein coding gene ChrX:130785195-130858849 (-)
CAST/EiJ MGP_CASTEiJ_G0035117
 protein coding gene ChrX:120638888-120712683 (-)
CBA/J MGP_CBAJ_G0035803
 protein coding gene ChrX:148320475-148406224 (-)
DBA/2J MGP_DBA2J_G0035961
 protein coding gene ChrX:138284196-138360742 (-)
FVB/NJ MGP_FVBNJ_G0035895
 protein coding gene ChrX:137511191-137583495 (-)
LP/J MGP_LPJ_G0036052
 protein coding gene ChrX:140774784-140860777 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035931
 protein coding gene ChrX:155955178-156046660 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036678
 protein coding gene ChrX:139123697-139199567 (-)
PWK/PhJ MGP_PWKPhJ_G0034811
 protein coding gene ChrX:117450997-117525758 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034636
 protein coding gene ChrX:121148121-121224532 (-)
WSB/EiJ MGP_WSBEiJ_G0035252
 protein coding gene ChrX:137517305-137591953 (-)



Homology
more
  • Human Ortholog
    ACSL4, acyl-CoA synthetase long chain family member 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACSL4, acyl-CoA synthetase long chain family member 4
  • Synonyms
    ACS4, FACL4, LACS4, MRX63, MRX68, XLID63
  • Links
    NCBI Gene ID: 2182
    neXtProt AC: NX_O60488
    UniProt: O60488

  • Chr Location
    Xq23; chrX:109641330-109733403 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    2 with human ACSL4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Female heterozygotes for a targeted null mutation exhibit accumulation of prostaglandins in the uterus, reduced fertility with few and small litters, and very low transmission of the mutant allele.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1308
  • Tissues
    191
  • cDNA Data
    15
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031278 Ensembl Gene Model | MGI Sequence Detail 72543 C57BL/6J ±  kb
    transcript ENSMUST00000112907 Ensembl | MGI Sequence Detail 5137 Not Applicable  
    polypeptide ENSMUSP00000108528 Ensembl | MGI Sequence Detail 711 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 15
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2147955
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 18
    • Earliest
      J:60348 Li Z, et al., Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction [see comments]. Science. 2000 Feb 11;287(5455):1046-9
    • Latest
      J:327352 Grube J, et al., ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression. Cell Death Dis. 2022 Aug 13;13(8):704
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    09/22/2022
    MGI 6.21     		The Jackson Laboratory