Fbxl3 MGI Mouse Gene Detail - MGI:1354702 - F-box and leucine-rich repeat protein 3

Fbxl3 Gene Detail

Symbol

Fbxl3
Name

F-box and leucine-rich repeat protein 3
Synonyms

Fbl3a, Fbxl3a, Ovtm, Play68

Feature Type

protein coding gene
IDs

MGI:1354702
NCBI Gene: 50789
Gene Overview

MyGene.info: FBXL3

Sequence Map

Chr14:103080239-103099566 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

19328 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 51.73 cM, cytoband E2.2
Mapping Data

3 experiments

Human Ortholog

FBXL3, F-box and leucine rich repeat protein 3

Vertebrate Orthologs

9

Human Ortholog

FBXL3, F-box and leucine rich repeat protein 3
Orthology source: HomoloGene, HGNC
Synonyms

FBL3, FBL3A, FBXL3A
Links

HGNC:13599

NCBI Gene ID: 26224

neXtProt AC: NX_Q9UKT7

UniProt: Q9UKT7
Chr Location

13q22.3; chr13:76992597-77027196 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8127
1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
HCOP

human homology predictions: FBXL3
Protein SuperFamily

conserved protein with F-box/LRR-repeat, Skp2 type
Gene Tree

Fbxl3

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Phenotype Summary

3 phenotypes from 7 alleles in 9 genetic backgrounds
4 phenotypes from multigenic genotypes
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Chemically induced (ENU)

4
Chemically induced (other)

1
Gene trapped

27
Targeted

2
Genomic Mutations

1 involving Fbxl3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available

Both heterozygous and homozygous mutant mice display a longer free running period than that of wild-type mice.

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All GO Annotations

22
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

4
Tissues

4
cDNA Data

12
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN fbxl3a

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Fbxl3 interacts with 336 markers (Mir7-1, Mir9-1, Mir9-2, ...) View All

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All Sequences

64
RefSeq

14
UniProt

6
CCDS

CCDS27315.1, CCDS84159.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000033217	VEGA Gene Model \| MGI Sequence Detail	19328	C57BL/6J	± kb
transcript	OTTMUST00000083206	VEGA \| MGI Sequence Detail	3352	Not Applicable
polypeptide	OTTMUSP00000044669	VEGA \| MGI Sequence Detail	428	Not Applicable

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SNPs within 2kb

67 from dbSNP Build 142

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UniProt

6 Sequences
Protein Ontology

PR:000007382 F-box/LRR-repeat protein 3

(term hierarchy)
InterPro Domains

IPR001810 F-box domain

IPR032675 Leucine-rich repeat domain superfamily

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All nucleic 12

cDNA 12

Microarray probesets 4

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MGI:2145757, MGI:2145805, MGI:2661838, MGI:3606318

Summaries

All 53

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 26
Earliest

J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
Latest

J:240095 Shi G, et al., Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function. Cell Rep. 2016 Feb 02;14(4):823-34

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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