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Fbxl3 Gene Detail
Summary
  • Symbol
    Fbxl3
  • Name
    F-box and leucine-rich repeat protein 3
  • Synonyms
    Fbl3a, Fbxl3a, Ovtm, Play68
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354702
    NCBI Gene: 50789
  • Gene Overview
    MyGene.info: FBXL3
Location & Maps
more
  • Sequence Map
    Chr14:103080239-103099566 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      19328 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 51.73 cM, cytoband E2.2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FBXL3, F-box and leucine rich repeat protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FBXL3, F-box and leucine rich repeat protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FBL3, FBL3A, FBXL3A
  • Links
    NCBI Gene ID: 26224
    neXtProt AC: NX_Q9UKT7

  • Chr Location
    13q22; chr13:77001339-77027196 (-)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 6 alleles in 8 genetic backgrounds
    3 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    33
  • Chemically induced (ENU)
    3
  • Chemically induced (other)
    1
  • Gene trapped
    27
  • Targeted
    2
  • Genomic Mutations
    1 involving Fbxl3
  • Incidental Mutations
    Mutagenetix , APF
Both heterozygous and homozygous mutant mice display a longer free running period than that of wild-type mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    4
  • Tissues
    4
  • cDNA Data
    12
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033217 VEGA Gene Model | MGI Sequence Detail 19328 C57BL/6J ±  kb
transcript OTTMUST00000083205 VEGA | MGI Sequence Detail 4309 Not Applicable  
polypeptide OTTMUSP00000044668 VEGA | MGI Sequence Detail 428 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    67 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000007382 F-box/LRR-repeat protein 3
  • InterPro Domains
    IPR001810 F-box domain
    IPR032675 Leucine-rich repeat domain, L domain-like
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 4
Other
Accession IDs
less
MGI:2145757, MGI:2145805, MGI:2661838, MGI:3606318
References
more
  • Summaries
    All 49
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 25
  • Earliest
    J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
  • Latest
    J:224530 Dietrich JE, et al., Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. EMBO Rep. 2015 Aug;16(8):1005-21
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory