Fbxl3 MGI Mouse Gene Detail - MGI:1354702 - F-box and leucine-rich repeat protein 3

Symbol

Fbxl3
Name

F-box and leucine-rich repeat protein 3
Synonyms

Fbl3a, Fbxl3a, Ovtm, Play68

Feature Type

protein coding gene
IDs

MGI:1354702
NCBI Gene: 50789
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:103318470-103337016 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 51.73 cM, cytoband E2.2
Mapping Data

3 experiments

SNPs within 2kb

918 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354702	protein coding gene	Chr14:103317675-103337016 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021629	protein coding gene	Chr14:99569779-99589159 (-)
A/J	MGP_AJ_G0021587	protein coding gene	Chr14:96277363-96300848 (-)
AKR/J	MGP_AKRJ_G0021563	protein coding gene	Chr14:99157037-99179247 (-)
BALB/cJ	MGP_BALBcJ_G0021593	protein coding gene	Chr14:96628279-96647810 (-)
C3H/HeJ	MGP_C3HHeJ_G0021371	protein coding gene	Chr14:99058095-99079206 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022033	protein coding gene	Chr14:103587551-103611651 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019573	protein coding gene	Chr14:93151215-93170306 (-)
CAST/EiJ	MGP_CASTEiJ_G0020888	protein coding gene	Chr14:96398721-96420680 (-)
CBA/J	MGP_CBAJ_G0021339	protein coding gene	Chr14:107304070-107325431 (-)
DBA/2J	MGP_DBA2J_G0021463	protein coding gene	Chr14:95773947-95794787 (-)
FVB/NJ	MGP_FVBNJ_G0021440	protein coding gene	Chr14:94752283-94771606 (-)
LP/J	MGP_LPJ_G0021531	protein coding gene	Chr14:100388631-100408326 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021467	protein coding gene	Chr14:110153847-110175826 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022056	protein coding gene	Chr14:98678301-98701483 (-)
PWK/PhJ	MGP_PWKPhJ_G0020631	protein coding gene	Chr14:92768910-92788402 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020469	protein coding gene	Chr14:94726211-94745595 (-)
WSB/EiJ	MGP_WSBEiJ_G0020941	protein coding gene	Chr14:99338387-99358253 (-)

Human Ortholog

FBXL3, F-box and leucine rich repeat protein 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXL3, F-box and leucine rich repeat protein 3
Synonyms

FBL3, FBL3A, FBXL3A, IDDSFAS
Links

HGNC:13599

NCBI Gene ID: 26224

UniProt: Q9UKT7
Chr Location

13q22.3; chr13:76992598-77027195 (-) GRCh38

MGI Vertebrate Homology

Fbxl3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FBXL3
Gene Tree

Fbxl3

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Phenotype Summary

23 phenotypes from 9 alleles in 11 genetic backgrounds
4 phenotypes from multigenic genotypes
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

37
Chemically induced (ENU)

5
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

26
Targeted

3
Genomic Mutations

1 involving Fbxl3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Both heterozygous and homozygous mutant mice display a longer free running period than that of wild-type mice.

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All GO Annotations

41
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

4
cDNA Data

13
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbxl3

ZFIN fbxl3a

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All Sequences

74
RefSeq

16
UniProt

6
CCDS

CCDS27315.1, CCDS84159.1

Ensembl

ENSMUSG00000022124 (Evidence)
NCBI Gene

50789

			Length	Strain/Species	Flank
genomic	50789	NCBI Gene Model \| MGI Sequence Detail	18547	C57BL/6J	± kb
transcript	NM_015822	RefSeq \| MGI Sequence Detail	3486	C57BL/6
polypeptide	Q8C4V4	UniProt \| EBI \| MGI Sequence Detail	428	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007382 F-box/LRR-repeat protein 3

(term hierarchy)
InterPro Domains

IPR001810 F-box domain

IPR036047 F-box-like domain superfamily

IPR032675 Leucine-rich repeat domain superfamily

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All nucleic 13

cDNA 13

Microarray probesets 4

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MGI:2145757, MGI:2145805, MGI:2661838, MGI:3606318

Summaries

All 71

Developmental Gene Expression 1

Gene Ontology 15

Phenotypes 34
Earliest

J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fbxl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130103	Chr14:103336996-103337007 (-)	14 bp
Tssr130102	Chr14:103336935-103336986 (-)	55 bp
Tssr130101	Chr14:103336923-103336933 (-)	88 bp
Tssr130100	Chr14:103336427-103336481 (-)	562 bp
Tssr130099	Chr14:103336391-103336406 (-)	617 bp
Tssr130098	Chr14:103336332-103336343 (-)	678 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24