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Fbxw4
Gene Detail
 Symbol
Name
ID
Fbxw4
F-box and WD-40 domain protein 4
MGI:1354698
Synonyms dactylin, dactylyn, Fbw4
Feature Type protein coding gene
Genetic Map
Chromosome 19
38.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr19:45578254-45660312 bp, - strand
From VEGA annotation of GRCm38

  82059 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32197  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fbxw4

Human
homologs
Human Homolog FBXW4, F-box and WD repeat domain containing 4
NCBI Gene ID 6468
neXtProt AC  NX_P57775
Human Synonyms  DAC, FBW4, FBWD4, SHFM3, SHSF3
Human Chr (Location)  10q24; chr10:101610664-101695588 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(14) Spontaneous(2) Targeted(6)
Genomic Mutations involving Fbxw4 (4)
Incidental mutations (data from APF )
 
Homozygotes for a spontaneous null mutation lack feet except for a single fused digit and die prenatally. Heterozygotes, in the presence of a recessive modifying allele, show loss of digits, frequently with fused metatarsal and metacarpal bones.
 
Alleles Annotated to Human Diseases(2)    Phenotype Images(1)
Interactions
Fbxw4 interacts with 59 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cartilage development, embryonic digit morphogenesis, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (48)    Tissues (28)    Images (8)
Theiler Stages: 17, 23
Assay TypeResults
RNA in situ 43
RT-PCR 5
cDNA source data(67)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(70) Genomic(2) cDNA(67) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034259 (Evidence)
Ensembl Gene ModelENSMUSG00000040913 (Evidence)
Entrez Gene30838 (Evidence)
UniGene254739
DFCITC1578559
DoTSDT.533502
NIA Mouse Gene IndexU039094
Consensus CDS ProjectCCDS29863.1
International Mouse Knockout Project StatusFbxw4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034259 VEGA Gene Model | MGI Sequence Detail 82059 C57BL/6J ±  kb
transcript OTTMUST00000087049 VEGA | MGI Sequence Detail 2068 Not Applicable 
polypeptide OTTMUSP00000047199 VEGA | MGI Sequence Detail 410 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(15) UniProt(8)
Polymorphisms SNPs within 2kb(567 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001810 F-box domain, cyclin-like
InterPro IPR001680 WD40 repeat
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000007425 F-box/WD repeat-containing protein 4
References (Earliest) J:6607 Chai CK, Dactylaplasia in mice a two-locus model for development anomalies. J Hered. 1981 Jul-Aug;72(4):234-7
(Latest) J:200863 Lockwood WW, et al., The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. PLoS One. 2013;8(5):e63610
All references(44)
Other
accession IDs
MGD-MRK-8791, MGI:94857

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory