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Fbxw4 Gene Detail
Summary
  • Symbol
    Fbxw4
  • Name
    F-box and WD-40 domain protein 4
  • Synonyms
    dactylin, dactylyn, Fbw4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354698
    NCBI Gene: 30838
Location & Maps
more
  • Sequence Map
    Chr19:45578254-45660312 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      82059 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FBXW4, F-box and WD repeat domain containing 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FBXW4, F-box and WD repeat domain containing 4
    Orthology source: HomoloGene
  • Synonyms
    DAC, FBW4, FBWD4, SHFM3, SHSF3
  • Links
    NCBI Gene ID: 6468
    neXtProt AC: NX_P57775

  • Chr Location
    10q24; chr10:101610664-101695037 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 32197
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: FBXW4
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Gene trapped
    14
  • Spontaneous
    2
  • Targeted
    6
  • Genomic Mutations
    4 involving Fbxw4
  • Incidental Mutations
    APF
Homozygotes for a spontaneous null mutation lack feet except for a single fused digit and die prenatally. Heterozygotes, in the presence of a recessive modifying allele, show loss of digits, frequently with fused metatarsal and metacarpal bones.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034259 VEGA Gene Model | MGI Sequence Detail 82059 C57BL/6J ±  kb
transcript OTTMUST00000087049 VEGA | MGI Sequence Detail 2068 Not Applicable  
polypeptide OTTMUSP00000047199 VEGA | MGI Sequence Detail 410 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    567 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 70
    Genomic 2
    cDNA 67
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-8791, MGI:94857
References
more
  • Summaries
    All 40
    Developmental Gene Expression 7
    Diseases 2
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:6607 Chai CK, Dactylaplasia in mice a two-locus model for development anomalies. J Hered. 1981 Jul-Aug;72(4):234-7
  • Latest
    J:200863 Lockwood WW, et al., The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. PLoS One. 2013;8(5):e63610

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory