Fbxw4
Gene Detail

Symbol Name ID

Fbxw4 F-box and WD-40 domain protein 4 MGI:1354698

Synonyms

dactylin, dactylyn, Fbw4

Feature Type

protein coding gene

Genetic Map

Chromosome 19

38.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr19:45578254-45660312 bp, - strand From VEGA annotation of GRCm38   82059 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32197  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fbxw4

Human homologs

Human Homolog		FBXW4, F-box and WD repeat domain containing 4
NCBI Gene ID		6468
neXtProt AC		NX_P57775
Human Synonyms		DAC, FBW4, FBWD4, SHFM3, SHSF3
Human Chr (Location)		10q24; chr10:103370421-103454743 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(16) : Gene trapped(14) Spontaneous(2)
 

Homozygotes for a spontaneous null mutation lack feet except for a single fused digit and die prenatally. Heterozygotes, in the presence of a recessive modifying allele, show loss of digits, frequently with fused metatarsal and metacarpal bones.

 
Alleles Annotated to Human Diseases(2)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process

cartilage development, embryonic digit morphogenesis, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (48)    Tissues (28)    Images (8)
Theiler Stages: 17, 23

Assay Type	Results
RNA in situ	43
RT-PCR	5

cDNA source data(67)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(70) Genomic(2) cDNA(67) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000034259 (Evidence)
Ensembl Gene Model	ENSMUSG00000040913 (Evidence)
Entrez Gene	30838 (Evidence)
UniGene	254739
DFCI	TC1578559
DoTS	DT.533502
NIA Mouse Gene Index	U039094
Consensus CDS Project	CCDS29863.1
International Mouse Knockout Project Status	Fbxw4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034259	VEGA Gene Model | MGI Sequence Detail	82059	C57BL/6J
transcript	OTTMUST00000087049	VEGA | MGI Sequence Detail	2068	Not Applicable
polypeptide	OTTMUSP00000047199	VEGA | MGI Sequence Detail	410	Not Applicable

All sequences(62) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(460 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001810	F-box domain, cyclin-like
InterPro	IPR001680	WD40 repeat
InterPro	IPR017986	WD40-repeat-containing domain
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000007425	F-box/WD repeat-containing protein 4

References

(Earliest) J:6607 Chai CK, Dactylaplasia in mice a two-locus model for development anomalies. J Hered. 1981 Jul-Aug;72(4):234-7
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(42)

Other accession IDs

MGD-MRK-8791, MGI:94857