About   Help   FAQ
Fbxl8 Gene Detail
Summary
  • Symbol
    Fbxl8
  • Name
    F-box and leucine-rich repeat protein 8
  • Synonyms
    FBL8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354697
    NCBI Gene: 50788
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:105264648-105269326 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.04 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    17 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354697
protein coding gene Chr8:105264648-105269326 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034032
protein coding gene Chr8:107529965-107534643 (+)
A/J MGP_AJ_G0034013
protein coding gene Chr8:103242607-103247285 (+)
AKR/J MGP_AKRJ_G0033939
protein coding gene Chr8:106226612-106231290 (+)
BALB/cJ MGP_BALBcJ_G0034006
protein coding gene Chr8:103417765-103422443 (+)
C3H/HeJ MGP_C3HHeJ_G0033718
protein coding gene Chr8:106972486-106977158 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034526
protein coding gene Chr8:111479151-111483829 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031468
protein coding gene Chr8:96391264-96396255 (+)
CAST/EiJ MGP_CASTEiJ_G0033044
protein coding gene Chr8:106471450-106476078 (+)
CBA/J MGP_CBAJ_G0033691
protein coding gene Chr8:115076537-115081213 (+)
DBA/2J MGP_DBA2J_G0033846
protein coding gene Chr8:102587185-102591864 (+)
FVB/NJ MGP_FVBNJ_G0033792
protein coding gene Chr8:101510836-101515500 (+)
LP/J MGP_LPJ_G0033937
protein coding gene Chr8:107741090-107745768 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033835
protein coding gene Chr8:118289362-118294040 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034544
protein coding gene Chr8:106200602-106205280 (+)
PWK/PhJ MGP_PWKPhJ_G0032745
protein coding gene Chr8:101972305-101976937 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032586
protein coding gene Chr8:104876333-104880953 (+)
WSB/EiJ MGP_WSBEiJ_G0033160
protein coding gene Chr8:106853708-106858378 (+)



Homology
more
  • Human Ortholog
    FBXL8, F-box and leucine rich repeat protein 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FBXL8, F-box and leucine rich repeat protein 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FBL8
  • Links
    NCBI Gene ID: 55336
    neXtProt AC: NX_Q96CD0
    UniProt: Q96CD0

  • Chr Location
    16q22.1; chr16:67159988-67164174 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9279
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FBXL8
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 50788 NCBI Gene Model | MGI Sequence Detail 4679 C57BL/6J ±  kb
transcript NM_015821 RefSeq | MGI Sequence Detail 1901 C57BL/6  
polypeptide Q8CIG9 UniProt | EBI | MGI Sequence Detail 374 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 19
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 4
  • Earliest
    J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/19/2019
MGI 6.13
The Jackson Laboratory