Rgs1
Gene Detail

Symbol Name ID

Rgs1 regulator of G-protein signaling 1 MGI:1354694

Synonyms

BL34

Feature Type

protein coding gene

Genetic Map

Chromosome 1

62.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:144243972-144249242 bp, - strand From VEGA annotation of GRCm38   5271 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2191  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs1

Human homologs

Human Homolog		RGS1, regulator of G-protein signaling 1
NCBI Gene ID		5996
neXtProt AC		NX_Q08116
Human Synonyms		1R20, BL34, IER1, IR20
Human Chr (Location)		1q31; chr1:192544857-192549159 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous null mice display increased splenic B cell germinal centers, increased chemotactic responses in B cells and immature dendritic cells, and decreased antibody secreting cell numbers.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	G-protein coupled receptor signaling pathway, negative regulation of signal transduction, ...
Component	cytoplasm, plasma membrane
Function	GTPase activator activity

External Resources: FuncBase

Expression

cDNA source data(99)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(99) cDNA(99)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000035154 (Evidence)
Ensembl Gene Model	ENSMUSG00000026358 (Evidence)
Entrez Gene	50778 (Evidence)
UniGene	103701
DFCI	TC1575085, TC1622723, TC1646744
DoTS	DT.101405065, DT.101405070, DT.94266928, DT.99852076, DT.99863788
NIA Mouse Gene Index	U021858
Consensus CDS Project	CCDS15349.2
International Mouse Knockout Project Status	Rgs1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035154	VEGA Gene Model | MGI Sequence Detail	5271	C57BL/6J
transcript	OTTMUST00000089512	VEGA | MGI Sequence Detail	1464	Not Applicable
polypeptide	OTTMUSP00000048930	VEGA | MGI Sequence Detail	209	Not Applicable

All sequences(43) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(72 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024066	Regulator of G-protein signaling, domain 1
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
Protein Ontology	PR:000013944	regulator of G-protein signaling 1

References

(Earliest) J:69278 Nagata Y, et al., A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood. 2001 May 15;97(10):3051-60
(Latest) J:179138 Gibbons DL, et al., Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential. J Immunol. 2011 Sep 1;187(5):2067-71
All references(33)