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Rgs1
Gene Detail
 Symbol
Name
ID
Rgs1
regulator of G-protein signaling 1
MGI:1354694
Synonyms BL34
Feature Type protein coding gene
Genetic Map
Chromosome 1
62.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:144243972-144249242 bp, - strand
From VEGA annotation of GRCm38

  5271 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2191  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs1

Human
homologs
Human Homolog RGS1, regulator of G-protein signaling 1
NCBI Gene ID 5996
neXtProt AC  NX_Q08116
Human Synonyms  1R20, BL34, HEL-S-87, IER1, IR20
Human Chr (Location)  1q31; chr1:192575727-192580029 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display increased splenic B cell germinal centers, increased chemotactic responses in B cells and immature dendritic cells, and decreased antibody secreting cell numbers.
 
Interactions
Rgs1 interacts with 187 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process G-protein coupled receptor signaling pathway, negative regulation of signal transduction, ...
Component cytoplasm, plasma membrane
Function GTPase activator activity
External Resources: FuncBase
Expression
cDNA source data(98)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(98) cDNA(98)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000035154 (Evidence)
Ensembl Gene ModelENSMUSG00000026358 (Evidence)
Entrez Gene50778 (Evidence)
UniGene103701
DFCITC1575085, TC1622723, TC1646744
DoTSDT.101405065, DT.101405070, DT.94266928, DT.99852076, DT.99863788
NIA Mouse Gene IndexU021858
Consensus CDS ProjectCCDS15349.2
International Mouse Knockout Project StatusRgs1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035154 VEGA Gene Model | MGI Sequence Detail 5271 C57BL/6J ±  kb
transcript OTTMUST00000089512 VEGA | MGI Sequence Detail 1464 Not Applicable 
polypeptide OTTMUSP00000048930 VEGA | MGI Sequence Detail 209 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
Protein Ontology PR:000013944 regulator of G-protein signaling 1
References (Earliest) J:69278 Nagata Y, et al., A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood. 2001 May 15;97(10):3051-60
(Latest) J:179138 Gibbons DL, et al., Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential. J Immunol. 2011 Sep 1;187(5):2067-71
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory