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Spag6
Gene Detail
Symbol

Name
ID
Spag6
sperm associated antigen 6
MGI:1354388
Synonyms
PF16
Feature Type
protein coding gene
Genetic Map
Chromosome 16
10.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:16753016-16829456 bp, - strand
From VEGA annotation of GRCm38

  76441 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8252  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SPAG6
Gene Tree: Spag6

Human
homologs
SPAG6, sperm associated antigen 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9576
neXtProt AC: NX_O75602

Human Synonyms: CT141, pf16, Repro-SA-1

Human Chr (Location): 10p12.2; chr10:22345416-22417610 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Many homozygotes for a targeted null mutation exhibit reduced growth, hydrocephaly, and lethality by 8 weeks of age. Surviving males have sperm defects and are infertile, while females show reduced fertility.
 
Interactions
Spag6 interacts with 124 markers (Mir18, Mir18b, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell projection organization, sperm axoneme assembly, ...
Component axonemal central apparatus, cell projection, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SPAG6 ; Xenbase spag6    NEW 
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(17) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000025639 (Evidence)
Ensembl Gene Model ENSMUSG00000022783 (Evidence)
Entrez Gene 50525 (Evidence)
UniGene 31701
DFCI TC1580192, TC1673258, TC1625365
DoTS DT.91437795, DT.91366553, DT.50315476, DT.101343999
NIA Mouse Gene Index U036831
Consensus CDS Project CCDS27988.1
International Mouse Phenotyping Consortium Status Spag6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025639 VEGA Gene Model | MGI Sequence Detail 76441 C57BL/6J ±  kb
transcript OTTMUST00000063093 VEGA | MGI Sequence Detail 2416 Not Applicable 
polypeptide OTTMUSP00000031166 VEGA | MGI Sequence Detail 507 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(128 from dbSNP Build 137)    SNPs within 2kb including multiple locations(130)
Protein-related
information
ResourceIDDescription
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR000357 HEAT
Protein Ontology PR:000015460 sperm-associated antigen 6
References
(Earliest) J:60694 Sapiro R, et al., Sperm antigen 6 is the murine homologue of the Chlamydomonas reinhardtii central apparatus protein encoded by the PF16 locus. Biol Reprod. 2000 Mar;62(3):511-8
(Latest) J:219924 Wang J, et al., Expression of prestin in OHCs is reduced in Spag6 gene knockout mice. Neurosci Lett. 2015 Apr 10;592:42-7
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory