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Spag6l Gene Detail
Summary
  • Symbol
    Spag6l
  • Name
    sperm associated antigen 6-like
  • Synonyms
    PF16, Spag6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354388
    NCBI Gene: 50525
  • Gene Overview
    MyGene.info: SPAG6
Location & Maps
more
  • Sequence Map
    Chr16:16753016-16829456 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      76441 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 10.39 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SPAG6, sperm associated antigen 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPAG6, sperm associated antigen 6
    Orthology source: HomoloGene
  • Synonyms
    CT141, pf16, Repro-SA-1
  • Links
    NCBI Gene ID: 9576
    neXtProt AC: NX_O75602

  • Chr Location
    10p12.2; chr10:22345416-22417610 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8252
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SPAG6
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Gene trapped
    1
  • Targeted
    1
  • Incidental Mutations
Many homozygotes for a targeted null mutation exhibit reduced growth, hydrocephaly, and lethality by 8 weeks of age. Surviving males have sperm defects and are infertile, while females show reduced fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025639 VEGA Gene Model | MGI Sequence Detail 76441 C57BL/6J ±  kb
transcript OTTMUST00000063093 VEGA | MGI Sequence Detail 2416 Not Applicable  
polypeptide OTTMUSP00000031166 VEGA | MGI Sequence Detail 507 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    126 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 1
    cDNA 17
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 5
  • Earliest
    J:60694 Sapiro R, et al., Sperm antigen 6 is the murine homologue of the Chlamydomonas reinhardtii central apparatus protein encoded by the PF16 locus. Biol Reprod. 2000 Mar;62(3):511-8
  • Latest
    J:219924 Wang J, et al., Expression of prestin in OHCs is reduced in Spag6 gene knockout mice. Neurosci Lett. 2015 Apr 10;592:42-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory